Xa abaninzi abantu bethetha malunga nokunyanga kwe- HIV , ngokubanzi becinga uhlobo oluthile lweziyobisi. Bacinga ukunyanga okuza kususa yonke intsholongwane emzimbeni-ukuphelisa ukupheliswa. Nangona kunjalo, oogqirha abaninzi abafuna ukunyangwa kwe-HIV bafuna uhlobo oluthile lokunyanga. Uphulo olusebenzayo lwe- HIV aluyi kubandakanywa ekupheliseni intsholongwane yonke emzimbeni.
Esikhundleni salo, injongo yokuphulukiswa komsebenzi yayiza kukukrazula yonke i-HIV kwigazi kwaye isuse nayiphi na imiphumo emibi. Ngamanye amagama, abantu abaye baphiliswa ngokusemthethweni babengeke bahlakulele ingculaza okanye ezinye iimpawu zesifo se-HIV, ezifana nokuguga kwangaphambili .
Ukwahlukana Phakathi Kokupheliswa Kwempilo kunye neNyango yokuSebenza
Umehluko omkhulu phakathi kokupheliswa kwonyango kunye nokunyanga okusebenzayo kuyinto efanelekileyo. Xa bekhangela unyango osebenzayo, izazinzulu akufanele zixhalabele ukuba ngaba zicocile ngempumelelo i-viral reservoir. (Inkunkuma yentsholongwane yinto leyo inzululwazi zibiza iikopi zentsholongwane ezifihla ngokuzithelayo kwiindawo ezahlukahlukeneyo zomzimba. Le ntsholongwane efihliweyo ayikwazi ukulwa okanye ukuphathwa kunyaka kwaye ngaphandle kokuba enye into ibangela ukuba isebenze kwaye iqale ukuvelisa.) Kunoko, ukuvavanya umntu ekunyangeni okusebenzayo, oogqirha kufuneka baqinisekise ukuba amanqanaba egazini egazini lawo ahlala engabonakaliyo.
Kwakhona kufuneka baqinisekise ukuba i-immune system isebenzayo kunye nokuba bekuya kuba bengenayo i-HIV.
Kwinqanaba elithile, oku kungenziwa ngoku ngoku-kusetyenziso oluqhubekayo lwe-antiretroviral (cART). Nangona kunjalo, ukulindela ngokubanzi kukuba ukunyanga okusebenzayo kuya kukwazi ukufezekisa ezi njongo ngaphandle kwezigulana ezifuna ukuhlala kwiCART ngonaphakade.
Nangona iziyobisi ezisetyenzisiweyo kwiCART ziye zaphucula kakhulu ubomi babantu abane-HIV, banokuba nemiphumo emibi kakhulu. Ngoko ke, ukunyanga okusebenzayo okufanelekileyo kuya kufumana izigulane ezinegciwane lesandulela ngculazi ukuya kwindawo apho izidakamizwa zazingasadingeki ukuze kugcinwe izifo zabo.
Indlela eya kwiNyango yeHIV esebenzayo
Ukunyangwa kwe-HIV kunokusebenza. Iindaba zonyango olu hlobo lwaqala ukugquma ngexesha lehlobo le-2012, xa kwakukho imigca ehlukeneyo yophando ebonisa ukuba i-HIV ingalawulwa kwamanye amaqela ezigulane. Iseshoni sokuqala yezifundo, ezithe zafumana uluntu olubanzi, zibandakanya umonde weBerlin. Umonde waseBerlin ngumntu onesifo sesandulela-ngculaza kubonakala sengathi uya kupheliswa emva kokuba enikwe ithambo lokutshintsha umongo kwi-CCR5. Uphando olwenziwe kwiNgqungquthela ye-19 ye-AIDS yelizwe lonke lwafumanisa amanye amathole emathambo abanikezelayo abanegciwane lesandulela ngculaza nabo babonakala belawulwa yi-transplant. Nangona kunjalo, olu hlobo lonyango aluyi kuba lukhetho kubantu abaninzi abane-HIV. Yingozi nje. Kuza kwenzeka ukuba kusetyenziswe izigulane ezitheleleke nge-HIV ezifuna ukutsalwa komongo wethambo kwezinye izizathu.
Okukuvuyisa ngakumbi kukuba iindidi ezininzi zenzululwazi ziye zaphumelela ukuphatha abantu ngokukhawuleza emva kokusulelwa yi-HIV. Kubonakala sengathi unyango lwangaphambili luyakwazi ukunqanda ukuphuhliswa kweendawo ezincinci zepirati. Unyango lwangokokuqala lunje lubonakala lukhupha umthamo wentsholongwane ephantsi kangangokuba izigulane zomzimba zezigulana zikwazi ukulawula nayiphi na intsholongwane eseleyo ngaphandle kokusetyenziswa kwezidakamizwa ze- antiretroviral . Iziphumo zisengaphambili. Nangona kunjalo, lo luhlobo lwesipilisi esisetyenziswayo, esinokuthi sisetyenziswe kwinqanaba elibanzi. Oku kuthetha, kuya kuba luncedo ngokwenene ukuba ukuhlolwa kwe- HIV kuphuculwe kakhulu.
Ngaphandle kokuba izifo zibanjwe kusasa, azikwazi ukunyangwa kwangoko. Okwangoku, abantu abaninzi kakhulu banentsholongwane iminyaka ngaphambi kokuba bafunde bane-HIV.
Imithombo:
Allers K, Hütter G, Hofmann J, Loddenkemper C, Rieger K, Thiel E, Schneider T. (2011) "Ubungqina bonyango losuleleko lwe-HIV nge-CCR5Δ32 / Δ32 ukuxilongwa kwe-cell stem." Igazi. 117 (10): 2791-9.
Bacchus, C., Hocqueloux, L., Avettand-Fenoe, V., Saez-Cirion, A., Melard, A., Descours, B., Sam, A., Blanc, C., Autran, B., Rouzioux , C., ii-VISCONTI kunye ne-ALT ANRS. "Ukusasazwa kwegciwane le-HIV kwizigulana ngokukhawuleza ukulawula intsholongwane kaGawulayo emva kokuphazamiseka kwonyango." AIDS 2012 Inkcazo THAA0103
> Henrich TJ, Hu Z, Li JZ, Sciaranghella G, i-Busch MP, i-Keating SM, i-Gallien S, i-Lin NH, i-Giguel FF, iLavoie L, i-Ho VT, i-Armand P, i-Soiffer RJ, i-Sagar M, uLasasce AS, i-Kuritzkes DR. Ukunciphisa ixesha elide kwigazi le-périphrali uhlobo lwe-HIV lwama-1 e-reservoirs emva kokunyanzeliswa kwe-allogeneic stem cell cell transplantation. J Disfect Dis. 2013 Juni 1; 207 (11): 1694-702. i-doi: 10.1093 / infdis / jit086.
> I-Poveda E, iCrespo M. Nini i-Antiretroviral Early Treatment Yonyango Elingenako ukukhutshwa kwe-HIV? I-AIDS Ingxelo ka-2017 kuMatshi-Juni: 19 (2): 113-114.
> Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C; I-ANRS VISCONTIQela lokuFunda. Abaphathi be-HIV-1 abane-long-term virological remission emva kokuphazamiseka kwonyango lokuqala lwe-antiretroviral ye-ANRS VISCONTI Study. PLoS Pathog. 2013 Mar; 9 (3): e1003211. i-doi: 10.1371 / iphephandaba.ppat.1003211.