Kungabonakala kungaqhelekanga ukufunda ukuba intsholongwane kaGawulayo ingabangela ukuguga kwangaphambili, kodwa kubonakala kuyinyani. Ukongezelela, ukuguga kwangaphambili akuyona nje into yentsholongwane kaGawulayo eyenza uqokelelo lweempawu eziqhelekileyo ezifumaneka kubantu abadala. Kunoko, impilo yonke yabantu abanezifo ezikhuselekileyo ze-HIV zifana nezo zabantu abangenayo i-HIV abaneminyaka engama-15 ubudala.
Ezinye zeengxaki zempilo eziqhelekileyo zokuguga ezenzeka ngaphambili ngaphambili kubantu abatsha abane-HIV zibandakanya:
- Ubunzima beCognitive - I-HIV ingakhokelela kwiingxaki ngeenkqubo zokucinga, imemori kunye nokulahlekelwa kwengqondo yengqondo.
- I-Bone Fragility - Abantu abanentsholongwane kaGawulayo banomngcipheko ophezulu kune-osteoporosis kunye namaqhekeza.
- Isifo sikashukela - Isifo sikashukela sinokuxhaphaka kubantu abane-HIV, nangona kungaziwa ukuba lukhulu kangakanani le nto ngenxa yentsholongwane kwaye kungakanani okubangelwa yimiphumo ye- HAART .
- Izifo Zeentliziyo Zomzimba - Ngokwengxenye ngenxa yeenguqu kwiipilisi zepilisi ezibangelwa yimithi ethile ye-HIV, abantu abane-HIV banomngcipheko ophezulu wokugula kwesifo somzimba kunye nezinye iingxaki zentliziyo.
- Ukungaphumeleli Kwezintso - Umngcipheko ophezulu wokungaphumeleli kweengtso kubangelwa ziphumo ezichanekileyo zesifo kunye nokwenza ngcono ukusuleleka kwizifo ezichaphazela ngqo iintso - njenge- hepatitis .
Abantu abaninzi abanentsholongwane kaGawulayo banelinye okanye ngaphezulu kwezi meko zokuguga kwangaphambili-into eyaziwa njenge- polypathology .
Nangona i-polypathology iphinda ibonakale kubantu abadala abadala abangenayo i-HIV, kubakho kwiminyaka engama-15 ngaphambili ngaphambili kubantu abantu abane-HIV-kubantu abaneminyaka engama-40 ubudala.
Ukuguga kusengaphambili kunokwenzeka kubantu abane-HIV nokuba ngaba bathatha imishanguzo ye-antiretroviral.
Enyanisweni, ezinye iindidi zezidakamizwa ze-antiretroviral zinokubangela ukuba izibonakaliso zokuguga zisengaphambili.
Kutheni i-HIV idala ukuguga kwangaphambili?
Kukho iingcinga ezininzi zokuthi kungani i-HIV inokubangela ukuguga kwangaphambili. Ezi zimbini zezona zifunyenwe kakuhle ziyi-mitochondrial toxicity and immunosenescence.
Kucingelwa ukuba inetyhefu yeMitochondrial ibangelwa ikakhulukazi ngokusebenzisa i- NRTI , kodwa kubonakala ngathi ivela kwizigulane ze-HIV ezingayithathi loo klasi yeziyobisi.
I-Mitochondria yayizikhululo zamandla zeseli - zenza enye yeekhemikhali ukuba imizimba yethu ifuna ukuqhubeka. Kubantu abanobuhlungu besifo se-mitochondrial, ezi feksi zincinci ziqala ukuvala kwaye zivelise. Ubuthi be-Mitochondrial budibene nenani leempawu zokuguga kwangaphambili, kuquka iingxaki ze-insulin kunye ne- lipodystrophy .
I-immunosenescence ibhekisela ekuhla kwe-immune system eyenzeka ngokudala, kodwa oko kwenzeka ngokukhawuleza kubantu abane-HIV. Yibangela ukunyanzelwa komzimba kunye nesimo esingapheliyo sokuvuvukala esinokuba nemiphumo emibi kwimpilo yonke.
Ukuvutha komgangatho ongezantsi kuyawuphawu lokuguga kubantu abadala abangenayo i-HIV. Nangona kunjalo, kucatshangelwa ukuba ukusetyenziswa rhoqo kwe-immune system nge-HIV yenye yezona zizathu zokuba kwenzeka ntoni kwi-HIV esemncinci.
> Imithombo:
> Capeau J. Ukuguga Kwangaphambi kokuguga kunye noNyaka obunxulumene nobudala obuchaphazelekayo kwi-HIV-Infected patients: Facts and Thoughts. Iiklinikhi ezingenayo. NgoDisemba ka-2011; 53 (11): 1127-9.
> Chang L, Andres M, Sadino J, Jiang CS, Nakama H, Miller E, Ernst T. Impembelelo ye-apolipoprotein E 4 kunye ne-HIV kwi-cognition kunye ne-brain atrophy: i-pleiotropy engavumiyo kunye nokuguga kwengqondo ngaphambi kokuqala. Neuroimage. Ngo-2011 Okthoba 15; 58 (4): 1017-27.
> Paik IJ, Kotler DP. Ukuxhaphaka kunye ne-pathogenesis yesifo sikashukela esidluliselwa ngoGawulayo. I-Best Pract Res Clin Clin Endocrinol Metab. 2011 Juni; 25 (3): 469-78.
> I-Maagaard A, i-Kvale D. Inetyhefu ye-mitochondrial kwizigulane ezinegciwane lesandulela-ngculazi kunye kunye nokunyangwa kwe-antiretroviral: i-continuum okanye indlela ehlukileyo yeendlela? J Antimicrob Chemother. 2009 Nov; 64 (5): 901-9.
> Rickabaugh TM, Kilpatrick RD, Hultin LE, Hultin PM, Hausner MA, Sugar CA, Althoff KN, Margolick JB, Rinaldo CR, Detels R, Phair J, Effros RB, Jamieson BD. Impembelelo emibini ye-HIV-1 isifo kunye nokuguga kwii-cell ze-CD4 ze-T4: iindidi ezongeziweyo kunye ezihlukeneyo zokukhubazeka. PLoS One. 2011 Jan 26; 6 (1): e16459.