UkuLawulwa kweeNkcukacha eziBalulekileyo
Stribild (eyaziwayo ngokuqhelekileyo njengepilisi ye-Quad) i-tablet-single, i-dose edibeneyo yesilwanyana esinezixhobo ezine- antiretroviral ezisetyenziselwa unyango lwe-HIV:
- i-tenofovir , i-nucleotide reverse transcriptase inhibitor
- emtricitabine, i-nucleotide reverse transcriptase inhibitor yesibini
- elvitegravir , integrase inhibitor
- i-cobicistat , i- HIV booster
I-Stribild yamkelwe yi-US Food and Drug Administration (i-FDA) ngo-Agasti 2012 ukuze isebenzise kubantu abadala abaneminyaka engama-18 nangaphezulu abaqala imishanguzo ye-antiretrovirals okokuqala, okanye abo bafumana unyango lwe-HIV abaye baphawula ngokupheleleyo (ingabonakali).
Ukhuseleko kunye nokusebenza kweStrive zavandlakanywa kwi-1,408 izigulane zabantu abadala abangazange baphathwe kwiimvavanyo ezimbini eziziimfama ezingaboniyo, ezinokuthi iStribild yayinempumelelo kwaye ibekezelekile njengeAtripla , esinye isilwanyana esilawulayo esinezixhobo ezibandakanya i-tenofovir, emtricitabine kunye ne- efavirenz .
Ngomnyaka we-2016, ukuqulunqwa kwangoko kweso siza esibizwa ngokuba yiGenvoya kwagunyazwa yi-FDA, kufaka indawo ye-tenofovir ngenguqulo entsha ebizwa ngokuba yi-tenofovir alafenamide (TAF), eyaziwa ukuba nemiphumo emibini kunye nezilwanyana eziphantsi.
UkuQulunqa
I-Stribild yipilisi eluhlaza, ene-oblong, ephetshwe ngefilimu, equkethe i-150mg ye-elvitegravir, i-150mg ye-cobicistat, i-200mg ye-emtricitabine kunye ne-300mg ye-tenofovir. I-GSI "ngapha nangapha kunye ne" 1 "equlethwe kwisikwere kwenye.
Isistim
Ithebhulethi nganye imihla ngemihla ithathwa ngokutya. I-strimin ayifanele ithathwe nayo nayiphi na isilwayo se-antiretroviral esisetyenziselwa ukuphatha i-HIV.
Imiphumela
Inani lemiphumo emibi yeziyobisi sele liphawulwe kwizigulane ezithatha iStriobraz. Iziganeko eziqhelekileyo eziqhelekileyo, ezichazwe kwi-7% okanye ngaphezulu izigulane, zi:
- I sizathu
- Uhudo
- Intloko
- Amaphupha angaqhelekanga
Ukusebenzisana kwezidakamizwa okanye ukungahambisani
Isitrafti akufanele sithathwe ngamachiza alandelayo okanye izongezelelo:
- Iyeza-anti-migraine: I-Cafergot, i-Migergot, i-Ergostat, i-Ergotamine, i-Wigraine, i-Wigrettes, i-Ergotrate, i-Methergine, i-DHE 45
- Iyeza-antitictictic: I-Orap
- Imithi ye-cholestol-yehlisa imithi: Zocor, Simcor, Vytorin, Mevacor, i-Advicor, i-Altoprev, i-Mevacor
- Imithi ye-Hepatitis B: i-Hepsera, Preveon
- Prokinetic agents: Propulsion, Propulsid Quicksolv
- Imithi yeprostate: Uroxatral
- Iipilonary hypertension medication: Revatio
- I-Rifampin-based based anti-tuberculosis amayeza: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Iziqhelo: I-Versed, iHalcion
- ISt John's Wort
Ukuqwalasela
I-stribild ingaba yingxaki kubantu abaneembali zeengxaki zeengtso. Nceda ucebise ugqirha wakho unayo nayiphi na imiba phambi kokuba uthathe iStribild. Umsebenzi weezintso kufuneka uhlolwe rhoqo kwizigulane kwiStriobraz. Yeka unyango kwizigulane ezinegunya lokuqikelela elidaliweyo elingaphantsi kwe-50mL / ngomzuzu. Iziyobisi ze-Neprotoxic akufanele zilawulwe ngokusesikweni kunye neStribild.
Izithako ezibini ezisebenzayo kwiStribild (i-tenofovir, emtricitabine) nazo zisebenza ngokutheleleka kwesifo se-hepatitis B (HBV) . Ukuba unayo i-HBV kwaye uyeka ukuthabatha iStribild, kuya kufuneka uhlole i-enzyme yesibindi kwiinyanga eziliqela njengoko ukuyeka ngamanye amaxesha kungabangela ukuba i-HBV ivuke.
Njengoko kunjalo nangomlinganiselo wokuqala we-antiretroviral regimens, ii-NRTI kwi-Stribild zidibene nomngcipheko omncinci we-lactic acidosis, kunye neengxaki zesibindi.
Ukuba ufumana ukuphefumula okufutshane; isicaphulo kunye nokuhlanza; intlungu okanye ukungalindelekanga kwesisu; ukunyaniseka nokukhathala; ubuthathaka kwiingalo nasemilenzeni; okanye u-yellowing wesikhumba kunye / okanye amehlo, biza ugqirha wakho ngokukhawuleza. I-latic acidosis, ngokukodwa, inokuba yingozi xa ingashiywa ingaphendulwa.
Imithombo:
US Food and Drug Administration. "I-FDA iyavuma ipilisi entsha yentsebenziswano ye-HIV kwezinye izigulane." Silver Spring, eMaryn; ukukhutshwa kwenkcazelo ekhutshwe ngomhla ka-Agasti 27, 2012.
Wohl, D .; Cohen, C; Gallant, J .; okqhubekayo. "I-Elvitegravir / cobicistat / emtricitabine / i-tenofovir DF (STB) inokusebenza ngokukhawuleza kwaye yahlula ukukhuseleka kwexesha elide kunye nokunyamezela ngokubhekiselele kwi-efavirenz / emtricitabine / i-tenofovir DF (ATR) ngeveki eyi-144 kwizigulane ezingama-HIV ezingahambiyo. INgqungquthela yama-53 kwiInterscience kwi-Agmistryal Agents kunye ne-Chemotherapy (ICAAC). Denver, Colorado, Septemba 11, 1013; H-672a.
Shalit, P .; Gallant, J .; IiMills, A .; okqhubekayo. "Ukunyamezela kwexesha elide elvitegravir / cobicistat / emtricitabine / tenofovir DF xa kuthelekiswa ne-efavirenz / emtricitabine / i-tenofovir DF okanye i-ritonavir-eyomelezwa i-atazanavir kunye ne-emtricitabine / i-tenofovir DF kwizifundo ezingenayo i-HIV-1 engenayo unyango." INgqungquthela yama-53 kwiInterscience kwi-Agmistryal Agents kunye ne-Chemotherapy (ICAAC). Denver, Colorado; Septemba 11, 2013; H-671.