Ukwahlula
I-Evotaz (atazanavir + cobicistat) yinyango echanekileyo yokudibanisa izidakamizwa ze-antiretroviral ezisetyenziselwa unyango lwe- HIV . Amacandelo amabini eziyobisi athengiswa ngabanye njengeReyataz (atazanavir) kunye neTybost (cobicistat) .
I-formulation form-formulate ivumela ukuba kube lula, ngokuphindaphindiweyo kwimihla ngemihla, kunye nenxalenye ye-cobicistat ngokuphumelelayo "ukukhulisa" kunye nokugcina ingxube ye-plasma ye-atazanavir emzimbeni.
I-Evotaz ivunyiwe yi-US Food and Drug Administration (FDA) ngoJanuwari 2015 kubo bonke abanezigulane ezitsha kunye nabafundi abadala abanentsholongwane kaGawulayo-1.
Ifomu
Ithebhulethi egciniweyo enefilimu, ene-300mg atazanavir kunye ne-150mg cobicistat, i-pink in color and embossed with the numbers "3641" kwelinye icala.
Isistim
Elinye ithebhulethi ithathwa imihla ngemihla ngokutya. I-Evotaz ayikwazi ukusetyenziswa yedwa kodwa kufuneka ithathwe ngokudibanisa kunye neyodwa okanye ngaphezulu kwezidakamizwa ze-antiretroviral.
Imiyalelo
Ngaphambi kokuqala, izigulane zifanele zivavanywe ukuvavanya ukuxhaswa kwazo kwe-creinine njengoko u-Evotaz inokuphazamisa umsebenzi we-kidal (kidney), ngokuqhelekileyo kwizigulane ezinezifo ezingaziwa okanye ezingafumaniyo. Xa ulawulwa yi- Viread (tenofovir ) -iziyobisi ezinokubangela ukukhubazeka kwe-renal kwezinye-kunconywa ukuba izigulane zivavanywe ngokusesikweni kwe-creinine imvume, urlucose umchamo kunye neprotein yamanzi.
Kukwacetyiswa ukuba izigulane ezinezigulane zonyango, ngokukodwa ezo zichazwe kwi- inhibitors ye-HIV , zinikezelwe ukuhlolwa kokumelana no-gene ngaphambi kokumiselwa kweVotaz.
Ukuba uvavanyo lwe-genotypic alufumaneki, i-Evotaz kufuneka igwenywe nabani na ngaphambili abachazwe kwi-inhibitors ye-HIV.
Iziphumo eziPhakathi
KwisiGaba III sesifundo sezonyango zomntu, ininzi yeziphumo zecala yeziyobisi ziye zachongwa xa usebenzisa i-Evotaz. Iziganeko eziqhelekileyo eziqhelekileyo, ezichazwe kwi-2% okanye ngaphantsi kwezigulane ezandululwayo, zi:
- I-jaundice (ukuphuka kwesikhumba kunye namehlo)
- I-eycular icterus (ukuphuka kwamehlo)
- Rash
- I sizathu
Iziphumo eziqhelekileyo ezichaphazelekayo zibandakanya ukukhathala, intloko, ukulala, ukuhlanza kunye nentlungu ephezulu. Iigwegwe zamatye nazo zaphawulwa kwezinye izigulane xa uEvotaz elawulwa yiViread (tenofovir), nangona amatyala ayebhekwa njengomnene kwaye awazange abe nemiphumo yokuyeka unyango.
Ukuchasana kweziyobisi
I-Evotaz ayifanele ithathwe ngamachiza alandelayo okanye izongezelelo zemfuyo:
- Iyeza-anti-anginal: Ranexa
- Amachiza olwaphulo-mthetho: i-Multaq
- Iyeza-anti-cholesterol: iMevacor, iZocor
- Iyeza-anti-gout: Uroxatral
- Amachiza e-anti-hypertension: I-Revatio
- Imithi ye-Antipsychotic: Latuda, Orap
- Imithi yonyango: iCamptosar, iCampto
- I-Ergot ene-anti-migraine derivatives: DHE 45, Ergotrate, Hydergine, Migranal
- I-Rifampin-based based anti-tuberculosis amayeza: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Ukuzihlaziya: iDormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
- ISt John's Wort
Ulwalamano lwe-Antiretroviral Drug
Ukusetyenziswa kweTybost ngokulandela izidakamizwa ze-antiretroviral kunokubangelwa kukulahlekelwa yempembelelo yokwelapha yesilwanyana esikhoyo okanye ukwanda kweempembelelo:
- I-Crixivan (indinavir) akufanele ilawulwe yi-Evotaz.
- Intelence (etravirine) akufanele ilawulwe yi-Evotaz.
- Sustiva (efavirenz) akufanele ilawulwe yi-Evotaz.
- I-Viramune (i-nevirapine) akufanele ilawulwe yi-Evotaz.
- Umlinganiselo we-Selzentry (maraviroc) kufuneka ulungiswe kwi-150mg kabini imihla ngemihla ukuba ulawulwa yi-Evotaz.
Okunye ukusebenzisana okanye ukuqwalasela
- Yazisa ugqirha wakho nayiphi na into eyaziwayo okanye enokumangalisa (intsi) imeko onokuyenza ngaphambi kokuba uqale uVotaz.
- Mxelele ugqirha wakho nayiphi na imeko eyaziwayo okanye esicatshulwayo (isibindi) onokuyenza ngaphambi kokuba uqale uVotaz, kubandakanya i-hepatitis A, i- hepatitis B okanye i- hepatitis C.
- I-Antacids ene-aluminium okanye i-magnesium hydroxide inokuthintela u-Evotaz ukuba athathwe ngokufanelekileyo. Ukuba usebenzisa i-anti-counter-counter-acacid (umzekelo, i-Rolaids, i-Tums, i-Milk yeMagnesia), kucetyiswa ukuba kuthathe iiyure ezimbini ngaphambi okanye emva kweDoloji yeVotaz.
- I- 2-i- anti-antagonists esetyenziselwa ukuvimba isisu esiswini (umz., ITagamet, i-Pepcid, i-Axid, i-Zantac) inokuthi ibambe u-Evotaz. Kucetyiswa ukuba bathathwe kunye no-Evotaz okanye, ngokunye, iiyure eziyi-10 phambi okanye emva kweDosota.
- Iproton pump inhibitors (umz., I-Losec, i-Prilosec, i-Prevacid, i-Nexium, i-Pariet) ingavimbela ngokufanayo ukutsalwa kwe-Evotaz. Kucetyiswa ukuba bathathwe iiyure ezili-12 ngaphambi okanye emva kweDosota.
- I-Erectile i-dysfunction medication (i-Viagra, i-Levitra, i-Cialis) kufuneka isetyenziswe ngokuqaphela njengoko u-Evotaz unokunyusa izinga lemiphumo emibi, kubandakanywa ukuphazamiseka okubonakalayo, ukuxhatshazwa, kunye nokuxhaswa (ukukhathazeka, ukulungiswa okuqhubekayo). Kunconywa ukuba i-Viagra isilinganisi iyancipha ibe ngaphezu kwama-25mg kwiiyure ezingama-48; Umthamo we-Levitra uyancipha ungabi ngaphezu kwama 2.5mg ngeeyure ezingama-72; kunye ne-Cialis isilinganisi sehla ukuba singabi ngaphezu kwe-10mg kwieyure ezingama-72.
- Ngethuba lokukhulelwa, uVevotaz akufanele abekwe ngexesha lesibini okanye lesithathu, ukuba isiguli esithweleyo sithatha i-H 2 -mvume okanye i-Viread (i-tenofovir) njengokuba kunokukho umngcipheko we-kernicterus (imeko engavumelekanga eyenzeka kwiintsana ezisanda kuzalwa jaundice enzima).
Imithombo:
Bristol-Myers Squibb. "I-Evotaz (Atazanvir + cobicistat) - UKUZIPHILA KWEZIXHUMA." ENew York, eNew York; fi kelele ngoFebruwari 3, 2015.