Ngasekupheleni kwee-1990, isilwanyana sokuqala se-biologic saya kwiimarike ukunyanga isifo se-rheumatoid arthritis . I-Enbrel (etanercept) yaqala, kodwa ayizange ithathe ixesha elide ukuba ezinye iziyobisi ze-biologic ziphuhliswe kwaye zithengiswe.
Ngokutsho kwe- UpToDate ( inkcazelo yekhompyutheni ethembekileyo esetyenziswa ngamagqirha amaninzi kunye nezigulana zifuna ulwazi olunzulu nolwazi olucacileyo lwezobisi ):
"Iinguqu ze-biologicalic modifiers, ezibizwa ngokuba yi-biologics, ziyizonyango eziye zenzelwe ukukhusela okanye ukunciphisa ukuvuvukala okulimaza amalunga. I-biologics ijolise i-molecule kwiiseli zomzimba womzimba, kunye kunye nemveliso efihliweyo ngokubambisana, yonke into zinokubangela ukuvuvukala kunye nokutshatyalaliswa ngokubambisana. Kukho iintlobo ezininzi zezinto eziphilayo, ezijolise kuyo uhlobo oluthile lwe-molecule echaphazelekayo kule nkqubo (i-tumor necrosis factor, i-interleukin-1 kunye ne-molecule yamaseli kwi-T ne-B lymphocyte). "
Izidakamizwa zeBioologic kunye neMigqaliselo yazo
- Enbrel (etanercept), Remicade (infliximab), i- Humira (adalimumab), i- Simponi (golimumab) kunye neCimzia (certolizumab pegol) ziyobisi eziphilayo ezijolise kwi-tumor necrosis factor (TNF). Ngokuqhelekileyo zibizwa ngokuba yi- block block ye-TNF kwaye, ngokuqhelekileyo, enye ye-block block ye-TNF yiyobisi yokuqala ye-biologic yazama.
- I Kineret (anakinra) inhibits interleukin-1. Ngokuqhelekileyo kuthathwe njenge-biologic engaphantsi kwee-blockers ze-TNF kwaye ayisoloko imiselwe.
- U-Orencia (abatacept) uphazamisa ukusetyenziswa kweeseli zeT. Ngokuqhelekileyo, i-Orencia igcinelwe izigulane ezinomlinganiselo ohambelana ne-rheumatoid arthritis abangakwazi ukulawula isifo sabo nge-methotrexate kunye ne-blocker ye-TNF.
- I-Rituxan (rituximab) igxotha iiseli zeB. Kwakhona, eli liyeza ligcinwa kwizigulane ezineempembelelo ezinganelisiyo kunye ne-methotrexate kunye ne-blocker ye-TNF.
- I-Actemra (tocilizumab) isebenza ngokuvimbela i-interleukin-6 receptor, ngaloo ndlela ivimba i-interleukin-6.
Ngubani Omele Ayenzululwe Ngezinto Eziphilayo?
Izigulane eziye zafumana impendulo enganelisekiyo kwii- DMARD (izifo eziguqula izifo ezibulala i -antirheumatic), nokuba zodwa okanye zidibene namanye amayeza e-arthritis, zivame ukuba ngabaviwa abafanelekileyo kwi-biologics. Xa kuthelekiswa ne-DMARD, i-biologics isebenza ngokukhawuleza. Kufuneka uyazi ukuba uyaphendula ngeveki zokuqala isilwanyana se-biologic.
Ngubani Akufanele Ajongane Nezinto Eziphilayo?
Ngelishwa, kukho izigulane ezingenabo abagqirha abafanelekileyo kunyango kunye neziyobisi ze-biologic. Kukho iimeko ezithile apho ingozi inokubakho ngaphezu kweenzuzo zonyango ngeziyobisi ze-biologic.
Ngokomzekelo, izigulane ezineembali eziphambili ze- sclerosis okanye i-lymphoma abayi kuba ngabaviwa abafanelekileyo. Izigulane ezineenkcukacha zesifo se-heart congressional disability are also candidates. Kwakhona kuyingozi kakhulu ukusebenzisa iziyobisi ze-biologic xa isiguli sinembali yezifo ezinzima okanye eziphindaphindiweyo.
Yiyiphi i-Biologics Okufanele Uyenzise?
Ugqirha wakho uya kukunceda ukhethe i-biologic engcono kakhulu kuwe. Iindleko ngokuqinisekileyo ziqwalaselwe. Wena kunye nogqirha wakho kufuneka unqume ukuba i-inshorensi yakho yezempilo iya kubhenca isilwanyana ozikhethayo-okanye ukuba yeyiphi iindleko zakho ezingaphandle.
Qinisekisa ukuba unokuhlawulela.
Enye ingqwalasela ilula. Inkunkuma elawulwa njani? Ngaba kufuneka ufike kwiofisi yegqirha ukuze unyango okanye ngaba kungcono ukuba ukhethe enye yezilwanyana ze-biologic ezilawulwa njenge-self-injection? Zingaphi iilisi ezilawulwayo-kanye ngeveki, kabini ngeveki, kwiiveki ezimbini, okanye ngenyanga? Ukhetha ntoni?
Kwakhona, kubalulekile ukuba ukhethe isiza esinerekhodi elungileyo, ngamanye amagama, elinye la badala, kunokuba litsha, i-biologics? Zizo zonke izinto oza kuziqwalasela kuba ukuba ukhetha oko kukuthandayo okulungileyo, uya kuqhubeka uhambelana nonyango lwakho.
Umthombo:
Maini RN kunye neVenables PJW. Ulwazi olulondekileyo: unyango lwe-rheumatoid arthritis "UpToDate.