Imibuzo Ephathelene Ne-Rheumatoid Arthritis Izidakamizwa
I-TNF inhibitors yimiyeza yokunyanga i-rheumatoid arthritis. Njengaye naziphi na iziyobisi, zinokusebenza kakuhle kubantu abathile kwaye kuncinci kwabanye. Nantsi ingqalelo kwii-inhibitors ze-TNF kunye nendlela ezisebenza ngayo, zithini iimiphumo zabo ezinokuthi zenzeke, kunye nendlela ezichanekileyo ngayo.
Yintoni i-TNF inhibitors?
I-TNF inhibitors ziyinkimbinkimbi, iziyobisi eziyinkimbinkimbi eziseklasini yemithi ebizwa ngokuba yi-biologics.
Basebenza ngokujolisa kwizinto ezibizwa ngokuba yi-tumor necrosis into ebangela ukuvuvukala. Ezinye i-biologics zokuphatha i-rheumatoid arthritis ziyi-antibodies.
I-Biologics yizilwanyana ezijolise kwiimelelekisi ezibangelwa ukuvuvukala kunye nokudibanisa amanxeba. Zivame ukunyulwa kubantu abathatha ezinye iindidi zamachiza e-arthritis, ezifana nee-DMARD (isifo sokuguqula iziyobisi ezichasene ne-rheumatic), kodwa kungenako ukufumana uncedo olwaneleyo.
Yintoni i-Tumor Necrosis Factor?
I-Norros Necrosis Factor yiprotheni eyenziwa ngumzimba wokhuseleko lomzimba. Idlala indima emininzi yemisebenzi ebalulekileyo yemvelo, njenge-fat metabolism kunye ne-coagulation, okanye i-clotting, yamaseli egazi. Iimeko ezithile, kuquka umhlaza kunye nezifo ezizimelayo njenge-rheumatoid arthritis, kunokubangela ukukhutshwa kwe-TNF, eyakhokelela ekuvukeleni.
Yintoni i-Antioclonal Antibody?
Uyazi ukuba ama-antibodies zizinto eziveliswe ngumzimba wokuzivikela omzimba ukulwa nama-antigens afana ne-virus.
Ama-antibodies aseMonoclonal akhiqizwa kwibhubhu kwaye yenzelwe ukujolisa kwiimeleleksi ezithile, ezifana ne-TNF.
Ukuthelekisa i-TNF Inhibitors
Kusoloko kubalulekile ukujonga ukufana kunye nokwahlukana phakathi kwemichiza xa wena kunye nogqirha wakho behlala kunonyango olulungile. Eminye imiba yokuqwalasela xa ukhetha phakathi kwe-block blockers ye-TNF yindlela nganye inikwa ngayo, imiphumo emibi, kunye neendleko.
I-Enbrel (etanercept) yiyilisi-anti-TNF. Yavunywe yi-US Food and Drug Administration (FDA) ngo-1998. I-Enbrel ivela ngokufaka i-DNA yabantu kwii-Chinese hamster ovary cell to create proteins.
I-Remicade (infliximab) yi-anti-monoglonal antibody ebophayo kwaye ibimbela i-tumor necrosis i-alpha (TNF-alpha). Kwakuyi-TNF yesibili inhibitor ukuba ivume i-FDA, ngo-1999.
I-Humira (adalimumab) "isifo esipheleleyo se-humocedal" esino-monoclonal antibody, esithetha ukuba ukuzenzela izidakamizwa kufana neloo-antibodies, nakuba lenziwe kwilebhu. U-Humira uvunyiwe yi-FDA ngo-2002.
Cimzia
I-Cimzia (certolizumab pegol) yiyona kuphela i-TNF inhibitor echaphazela ukuba ibe yinto enetyhefu kwiiseli ngenxa yeemveliso zamakhemikhali. Ukongeza, xa kuthelekiswa nezinye izidakamizwa ezichasene ne-TNF, iCimzia ibikwa ukuba inxulumene kakhulu ne-TNF yabantu.
Simponi
I-Simponi (golimumab) i-blocker ye-TNF-alpha enqunyelwe ukuba i-ulcerative colitis, i-psoriatic arthritis, kunye ne-spondylitis engabonakaliyo. Kuvunyiwe ngo-2004.
Iimiphumo ezingezantsi ze-TNF Blockers
Akukho zonyango ezingenayo imiphumo emibi. Ezinye iingxaki ezinokuthi zixhomekeke kwi-block blockers ze-TNF ziyaziwa kakuhle, kubangela ezinye izigulane ze-arthritis ziqaphele ukuthatha i-TNF inhibitors .
Kodwa kubantu abaninzi, izibonelelo zigqithise kakhulu ingozi.
Ezinye izigulane zithintela ukusuleleka xa ziphathwa ngeDMARD okanye iziyobisi ze-biologic. (Kuye kunjalo kwi-DMARD.)
Ucwaningo lwango-2016 lufumene ukuba abantu abathatha i-block block ye-TNF ye-rheumatoid arthritis babenomngcipheko kathathu wokuphucula ii-cancer ezithile, ezifana ne-lymphoma. Oku kwakuyinyani ngokukodwa xa bephezulu.
Funda ngayo yonke
I-Arthritis Ngaphandle Kwesifo - Ummangaliso we-TNF Blockers
Le ncwadi yi-rheumatologist uScott J. Zashin, MD, ichaza indlela abasebenzi be-TNF basebenze ngayo kwaye baqhathaniswa njani nezinye iziyobisi ze-arthritis.
Uquka amabali okuphumelela kwesigulane kwaye uya kwindlela le ndlela yokuqhubela phambili kwezidakamizwa yatshintshe ubomi.