I-TNF Blocker yokuqala evunyelwe i-Rheumatoid Arthritis ngo-1998
I-Enbrel (etanercept) yi-biologic response modifier (i-recombinant human tumoror neorrosis protein fusion protein). I-Enbrel iveliswa ngezofuzo ukuze ibe njengezifunyenwe emzimbeni obopha kwi- tumor necrosis factor (TNF-alpha). I-Enbrel isebenza ngokukhupha i- TNF engaphezulu ngaphambi kokuba inamathele kwiimvelo zamkeli.
I-TNF-alpha yi- cytokine ebandakanyekayo kwinkqubo yokuvuvukala.
I-TNF-alpha eyongezelelekileyo idibene ne- rheumatoid arthritis kunye nezinye iirmritis ezivuthayo .
Zi yobisi
I-Enbrel yayisisisixhobo sokuqala se-TNF kwaye savunywa ngo-1998 kwi-arthritis ye-rheumatoid kunye neentlobo ezithile zokuvuvukala kwe-arthritis. I-Remicade (infliximab) yayiyesibili ye-TNF inhibitor eya kuvunywa yi-US Food and Drug Administration ngo-1999. I- Humira (adalimumab) yavunywa ngo-2002. I- Simponi (golimumab) yavunywa yi-FDA ngo-Ephreli 24, 2009. I- Cimzia (certolizumab pegol ) ivunyiwe yi-FDA ngoMeyi 14, 2009.
I-Enbrel itholakala ngokuzisa i-DNA yabantu kwii-Chinese hamster ovary cells kunye nokudala iprotheni engumzimba. I-Remicade isebenzisa iiprotheni zomntu kunye ne mouse ukuqinisekisa i- anti- chimeric antibody . U-Humira usebenzisa iiprotheni zomntu ngokupheleleyo kunye nobuchwepheshe bokubonisa ubuchwephesha ukuvelisa i-anti-body antibodies.
Lawulo
I-Enbrel ilawulwa njengomjovo ongaphantsi kwesinye okanye kabini ngeveki (iintsuku ezintathu okanye ezine ngaphandle).
Umlinganiselo omiselweyo kuxhomekeke kwimeko ephathwayo. I-Enbrel kufuneka icetywe ngugqirha wakho kwaye idinga i-inshurensi yangaphambili. I-Enbrel ingasetyenziselwa kunye kunye ne-methotrexate kwizigulane ezingaphenduliyo kwi-methotrexate yodwa.
Umyalelo
I-Enbrel ivunyelwe ukunyanga ngokumalunga ne-rheumatoid arthritis, i-moderation, i- psoriatic arthritis , i- sporyritis e-ankylosing , i-psoriasis engapheliyo.
Isisombululo esinconywayo
Kubantu abadala abane-arthritis ye-rheumatoid, i-psoriatic arthritis, kunye ne-spondylitis e-ankylosing, i-dobrel ye-Enbrel ingama-50 mg nganye ngeveki elawulwa njenge-injection subcutaneous usebenzisa i-syringe engama-50 mg / ml. Kukho izigulane ezingama-25 mg ze-Enbrel ezikhoyo.
Isilinganiselo se-Enbrel esilungiselelwe isifo samathambo esisiswini sesisu sisekelwe kwisisindo somntwana. Ukukhethwa kwesithuba seveki esisodwa seveki kukho abantwana abanesisindo ezili-138 okanye ngaphezulu. I- psoriasis ye-plaque , umthamo oqhelekileyo ngowama-50 mg kabini ngeveki kwiinyanga ezi-3, wehla waya kanye ngeveki.
Ezixhalabelekileyo
I-Enbrel ayikhuthazwa ngabasetyhini abakhulelweyo okanye abahlengikazi. Izigulane ezinobungozi obukhulu akufanele ziphathwe nge-Enbrel. Abantu abanokusuleleka kwintsholongwane okanye abo abane-diabetes abangalawulwayo akufanele basebenzise i-Enbrel. Izigulane ezineemeko ezithile zesistim se-nervous kufuneka ziphephe i-Enbrel.
Iziphumo eziPhakathi
Iziphumo eziqhelekileyo ezichaphazelekayo ne-Enbrel ziquka:
- impendulo yendawo yomjovo
- izifo eziphezulu zokuphefumula, kubandakanywa nezifo zesifo
- intloko
- ukungcola
- impumlo enemifinya
- ukucasula umqala
Izimpembelelo ezibi kakhulu
I-Enbrel inokunyusa umngcipheko wezosuleleko. Kubantu abaphathwa nge-Enbrel, kukho iingxelo ze- multiple sclerosis , i-myelitis (ukuvuvukala kwentambo yomthambo), i-optic neuritis (ukuvuvukala kwe-nertic optic), ne-pancytopenia (iinombolo eziphantsi zamaseli obomvu, iiseli ezimhlophe, iiplatelets).
Ukugcina
I-Enbrel kufuneka igcinwe kwiqondo lokushisa kwama-36 ukuya kuma-46 degrees Fahrenheit. Nangona kunjalo, i-Enbrel inokugcinwa kwiqondo lokushisa ixesha elide ukuya kwiintsuku eziyi-14. I-Enbrel akufanele igcinwe kwifriji.
Ngokutsho kwe-enbrel.com, ukuba uhamba ngaphezu kweeyure ezimbalwa, kufuneka ugobe i-Enbrel kwi-bubble and cover it in a cooler travel packed with ice. Yongeza i-thermometer kwindawo epholile kwaye uyihlole nganye iiyure ezimbalwa. Unokufumana i-cooler travel travel kunye ne-ice pack ye-Enbrel ngokubiza i-Enbrel Support kwi-1-888-4ENBREL. Ukuba uhamba ngomoya, khangela i-airline malunga neemfuno zabo.
Imithombo:
IArthritis Ngaphandle Kwentlungu, uScott J. Zashin, MD, Epapashwe nguSarah Allison Publishing Inkampani.
Enbrel - I-Pill Book, i-10 Edition
Guide Guide. Enbrel.com. Ukuhlaziywa 11/2013. http://pi.amgen.com/united_states/enbrel/derm/enbrel_mg.pdf
Ulwaziso loLwazi. Enbrel.com. Ukuhlaziywa 03/2015. http://pi.amgen.com/united_states/enbrel/derm/enbrel_pi.pdf