Ukuqonda ingozi kunye neengxaki zonyango
I-Orencia (abatacept) yiyobisi ye- biologic evunyiweyo ukwenzela unyango lwe- rheumatoid arthritis . Kwakhona kusetyenziswa ukunyanga i- psoriatic arthritis kwaye ilandelelanise ukuba i-arthritis yengane enzima.
U-Orencia akayiyo i-blocker ye-TNF njenge- Enbrel (etanercept) okanye i- Humira (adalimumab) apho iprotheni evuzayo ebizwa ngokuba yi-tumor necrosis factor (TNF) ixinyiwe.
Kunoko, u-Orencia usebenza ngokuthintela izibonakaliso zamachiza ezibangelwa ukuhlaselwa ngokuzenzekelayo.
Unyango lufumaneka kwiindlela ezimbini:
- I-Orencia inokuhanjiswa kwimizuzu engama-30 engama-intravenous (IV) ukumnika zonke iiveki ezine emva kokuba i-dose yokuqala yokulayisha (umthamo wokuqala, umthamo wesibini kwiiveki ezimbini, kunye neentlawulo emva kweveki ezine emva koko).
- I-Orencia nayo iyafumaneka kwi-formulation subcutaneous eyenza abantu bazinike isibhozo kwintambo, isisu okanye ingalo engaphezulu. Uphulo luvame ukuqala nge dose yokulayisha i-IV elandelwa yincwadana engaphantsi komhla. Iilenki zizenzeke ngeveki nganye.
Ngoxa i-Orencia iyakwazi ukuthoba umonakalo kunye nokunciphisa intlungu ye-arthritic, kubalulekile ukuqonda ukuba isilwanyana sisebenza njani, xa sichazwe, kwaye yintoni, ukuba kukho na, ingozi idibene nokusetyenziswa. Nazi iinkcukacha ezintlanu ezinokukunceda:
1. I-Orencia Iyabhalwa Ngokuqhelekileyo Emva Kwezinye Iingonyango Ziphumelele
U-Orencia uvame ukusetyenziswa kubantu abaneemodareyithithi ezinzulu zesifo se-rheumatoid abangazange basabele kwisinye okanye ngaphezulu kwezidakamizwa zokubulala izifo ( DMARD ) ezifana ne- methotrexate okanye ezinye i-biologics ezifana ne-Enbrel okanye i-Humira.
I-Abatacept ingasetyenziselwa yodwa okanye idibene ne-DMARD, eyenza ibe yinto enamandla kakhulu, kodwa ingekho kwezinye iziyobisi ze-biologic. U-Orencia unokuqwalaselwa ngonyango wokuqala kumntu kubantu abane-arthritis yokuqala ye-rheumatoid.
2. U-Orencia Usebenza ngokuCima iSistim yoHluma
Iziyobisi ze-biologic ezisetyenziswa ekuphatheni i-rheumatoid arthritis zijolise ekukhuseleni amasosha omzimba ekuhlaseleni izicubu zawo, ngokukodwa ezo zidibeneyo.
Ukwenza oku, iziyobisi zifuna ukuvala izixhobo zokuphendula omzimba. Ngokwenza njalo, iphuma emzimbeni evulelekileyo kwiintsholongwane zingayilwa. Ezi ziqhelekileyo zezi zibandakanya izifo zokuphefumula (kuquka i-pneumonia), i-arthritis ye-septic, i-skin and soft tissue infections, kunye ne-urinary tract infections.
Nangona kunjalo, uphando oluninzi lubonise ukuba i-Orencia idibene nomngcipheko ophantsi kakhulu wokusuleleka usulelo kunye nokulala esibhedlele xa kuthelekiswa neEbrel, Rituxan (rituximab), kunye ne-Actemra (tocilizumab).
3. Abantu base-Orencia basengozini yokunyuka kwesifo sofuba
Oyintloko phakathi kokuxhalaba ngumngcipheko wesifo sofuba (TB), ngokukodwa ukuvuselelwa kwe-TB kubantu abasulelekileyo. Uphando lubonisa ukuba abantu abavelele kwi-Orencia banokunyuka kwamaxesha amane emngciphekweni wokuqalisa kwakhona.
Ngaphambi kokuqala unyango, abantu kufuneka bahlolwe i-TB. Abantu abanentsholongwane echaphazelekayo ye-TB kufuneka baphathwe ngempumelelo ngaphambi kokuba naluphi na iziyobisi eziphilayo.
4. Abantu base-Orencia kufuneka baphephe iiglofu eziphilayo ngelixa zonyango
Izigulane ezithintekayo ziphila zizinto eziphilayo, ezinobuthakathaka begciwane (ngokuchasene neentsholongwane ezingasebenzi ezingasetyenziswa "iintsholongwane" ezibulawe).
Ngenxa yokuba u-Orencia unciphisa amandla okukhusela omzimba, kukho ithuba lokuba isitofu sokuphila singabangela ukuba isifo esifanele ukukhusela.
Ngaloo ndlela, abantu base-Orencia bayacetyiswa ukuba baphephe iigciwane eziphilayo ngaphambi kokuqala kokonyango, ngexesha lokonyango, kunye neenyanga ezintathu emva kokupheliswa kwonyango. Ezi ziquka:
- Umkhuhlane we-FluMist ( FluMist )
- Ukugonya kwe-Shingles
- I-Varicella (inkukhu)
- Ukugonya kwe-Measles-mumps-rubella (MMR)
- I-Rotavirus vaccine
- Isifo sokugonya somkhuhlane
- Tyhafile
5. U-Orencia kufuneka Usetyenziswe Ngokulumkisa kubantu abaneCOPD
Kwizilingo zesikliniki, abantu abanesifo esingapheliyo sesifo se-pulmary disease ( COPD ) bafumana inqanaba eliphezulu le- COPD ngexesha lo-Orencia, kubandakanywa ukukhwehlela okuqhubekayo, ukuphefumula okufutshane, kunye nokuphefumula.
Ngenxa yoko, u-Orencia kufuneka asetyenziswe ngokulumkisa kubantu abane-COPD, enomlinganiselo weenzuzo ezichasene nemiphumo enokwenzeka. Ukongezelela, kufuneka kunikwe inkxaso eninzi ekujongeni abantu abaneCOPD xa kwenzeka iimpawu zokuphefumula ziba nzima. Kwimeko enjalo, unyango lungadinga ukuma.
> Imithombo:
> De Keyser, F. "Ukukhethwa kweTyhuloji yeBioologic kwizigulane nge-Rheumatoid Arthritis: I-Persistective Infection." Curr Rheumatol Rev. 2011; 7 (1): 77-87. INGXELO: 10.2174 / 157339711794474620.
> Yun, F .; Xie, F .; Delzell, E. et al. "Umngcipheko wokuqhathaniswa weNtsholongwane yokuHlanywa kweziBhedlele eziHlangeneyo kunye neAjologic Agents kwi-Rheumatoid Arthritis Izigulane ezibhaliswe kwi-Medicare." Arthritis & Rheumatology . 2015; 68: 56-66. INGXELO: 10.1002 / ubugcisa.39399.