Isiyobisi se-biologic injectable ye-rheumatoid arthritis
I-Adalimumab, eyaziwa ngokuqhelekileyo njengeHuma, isilwanyana se-biologic esisebenza ngokuthintela iprotheni ebizwa ngokuba yi- TNF-alpha . Ngokuqhelekileyo, i-TNF-alpha inceda ukulwa nokusuleleka, kodwa ngokugqithiseleyo, kungabangela ukuvutha okubuhlungu kunye nomonakalo odibeneyo (oko kukuthi iimpawu eziqhelekileyo zesifo se- rheumatoid arthritis nezinye iintlobo zesifo se- arthritis ). Izidakamizwa ezifana ne-Humira ziye zanceda izigulane ezininzi ze-rheumatoid zezifo ngokuphelisa intlungu, ukuphucula ukusebenza kunye kunye nokunciphisa ukunyuka kwesifo.
Sibanzi
U-Humira ungumntu ophilileyo owenziwe ngumntu oyedwa. Oku kuthetha ukuba, nangona kwenziwa kwiinkqubo ezingezizo ze-biologic, i-protein yangempela yokwenza izidakamizwa kufana neyo-antibodies yabantu. Yaye le ndawo ehloniphekileyo iHuma evela kwi-blocker yase-monoclonal antibody TNF eyayivunyiwe phambi kwayo-ukuveliswa kwayo kwiprotheni kwathathwa inxalenye evela kumntu ongeyena umntu (mouse).
Ngo-2002, uHumira wavunywa kuqala yi-US Food and Drug Administration (FDA) njengonyango lwe-arthritis ye-rheumatoid. Ngenye yezilwanyana ezininzi ze-biologic ezivimba i-TNF-alpha, kuquka:
- Enbrel (Etanercept) : Isidakamizwa sokuqala se-TNF evunyiweyo yi-FDA yesifo se-rheumatoid kunye neentlobo ezithile zokuvuvukala kwe-arthritis ngo-1998.
- I-Remicade (i-Infliximab) : I-TNF yesibili inhibitor kufuneka ivunyiwe yi-FDA ngo-1999.
- Simponi (Golimumab) : Kuvunywe yi-FDA ngo-Ephreli 24, 2009.
- Cimzia (Certolizumab Pegol) : Ivunyiwe yi-FDA ngoMeyi 14, 2009.
Ukukhetha
U-Humira unikezwa ngamacandelwana (ngaphantsi kwesikhumba) ukuzonda injini kanye emva kweveki ezimbini. Izigulane ziyakucetyiswa ngugqirha ukuba ziyijobe ngeveki ukuba zonke iintsuku eziyi-14 zanele.
Kwakuqala ukufumaneka kusetyenziso olulodwa, isirinji esengaphambili. Ukusetyenziswa okunye, inkqubo yokuhanjiswa okulahlayo iye yaphuhliswa, eyaziwa ngokuba yi-Humira Pen.
I-dose ephakanyisiweyo, nangona kunjalo, ingama-40mg njenge-self-injection injongeniso esebenzisa isirinji esandulela okanye i-Humira ipenki nganye ngeveki. I-Methotrexate , ezinye i- DMARD ezingekho ze-biologic, i- glucocorticoids , izidakamizwa ezichasayo ezingabhubhisiyo (i-NSAID) , okanye i- analgesics (iilwimi zamachiza) zingagcinwa ngelixa ziphathwa ngeHuma. Nangona kunjalo, enye i-DMARD ye-biologic ayifanele isetyenziswe.
Iinkcazo
Izibonakaliso ezingaphezulu ziye zongezwa kwi-Huma kuba okokuqala kwavunywa yi-FDA. Inokumiselwa ukuba uphathe:
- Irheumatoid arthritis
- Ankylosing Spondylitis
- I-Psoriatic Arthritis
- I-Juvenile Idiopathic Arthritis
- Plaque Psoriasis
- Ulcerative Colitis
- Izifo zabadala kunye nezifo ze-Crohn's
- Hidradenitis Suppurativa
Imiphumela
Iziphumo eziqhelekileyo ezichaphazelekayo kunye neHuma ziquka:
- Ukuphendulwa kwesayithi esilula
- Rash
- Intloko
- Isisu esicasulayo okanye isicathulo
- Pneumonia
Izimpembelelo ezimbi
Ngenxa yokuba igxotha impendulo yomzimba kumzimba ovame ukulwa nesifo, u-Humira uye wadibana nezifo ezinzulu, ezifana nesifo sofuba, isifo se-sepsis kunye nezifo ezifayo. Kungadlukisa ngakumbi iimpawu zezifo zesimiso se-nervous (umz., Ukuphazamiseka kwesidemokhrasi). Kwizilingo zonyango, ezinye izigulane zinezinga eliphezulu lomhlaza kunye ne-lymphoma kwiinyanga ezingama-24.
Ngubani ongafanelanga ukuthatha iHuma
I-Humira akufanele isetyenziswe zizigulane ezinokwazi ukungahambi kakuhle kwilisi okanye izixhobo zayo. Kwakhona akufanele isetyenziswe zizigulane ezikhulelwe okanye zonesi.
Isilwanyana akufanele sichazwe isigulane esinentsholongwane echaphazelekayo okanye izigulane ezithintele ukusuleleka kwintsholongwane, kuquka nezigulane ezine- diabetes ezingalawulekiyo okanye izigulane ezinembali yezifo ezithintekayo.
Xelela ugqirha wakho
- Ukuba unentsholongwane echaphazelekayo
- Ukuba usulelekile nge-Hepatitis B okanye ngaba ngumphathiswa (u-Humira uye wadibana nokuvuselelwa kwe-Hepatitis B)
- Ukuba unobunzima, ukubetha, okanye i- multiple sclerosis okanye ingxaki yentsholongwane yentsholongwane
- Ukuba uphathwe ukusilela intliziyo
- Ngaphambi kokufumana naziphi na izitofu okanye utyando
Ukunika ingxelo ngempembelelo engathandekiyo, ungathintana no-AbbVie Inc.at 1-800-633-9110 okanye i-FDA kwi-1-800-FDA-1088 okanye kwi-www.fda.gov/medwatch.
Imithombo:
Zashin, MD, Scott J .. IArthritis ngaphandle kobuhlungu. Inkampani yaseSara Allison Publishing.
Humira . Abbott laboratories. Ulwaziso loLwazi. 2016.