I-Cimzia yi-TNF ibhocker esetyenziselwa i-arthritis evuthayo
I-Cimzia (certolizumab pegol) yi- TNF (i-tumor necrosis factor) i-blocker- inqanaba elifanayo leziyobisi njenge- Enbrel (etanercept) , i- Remicade (infliximab) , i- Humira (adalimumab) kunye ne-Simponi (golimumab). I-Cimzia yiyodwa yilisi kwinqanaba le-TNF elichaphazela ukuba lingasetyhefu kwiiseli ngenxa yamakhemikhali ayo (umz., I-PEGylated, iFC ekhululekile). Ukongezelela, xa kuthelekiswa namanye ama-blockers ase-TNF, iCimzia ibikwa ukuba inxulumene kakhulu ne-TNF yabantu.
Yintoni i-TNF?
Kunceda ukwazi ukuba yi-TNF ukuze ukwazi ukuqonda ukuba kungani iCimzia isebenza ukuyivimba. I-TNF iyi- cytokine , ngokuyisiseko isithunywa se-molecule phakathi kweeseli, ezenza indima kwinkqubo yokuvuvukala . Ukuveliswa kwe-TNF-alpha eyenziwa ngumzimba kuye kwadibaniswa nezifo kunye neemeko ezininzi, kubandakanya i- rheumatoid arthritis .
I-Cimzia Inikwe Njani?
I-Cimzia ijojowe phantsi kwesikhumba. Ikhutshwa njengomgubo omele uhlaziywe kwakhona kwi-formulation liquid, ngoko ke unokunikezwa njengesilwanyana esincinci.
Umenzi walo, u-UCB, Inc., wathi iindawo ezikhethiweyo zekhemikhali zeCimzia zingenza ukhetho olungcono kunabo abakhoyo be-TNF abakwizigulane ze-rheumatoid arthritis. Ukutyunjwa kwalo kunokunciphisa ukusabela okuchasene ne-injection kunye nokunikezelwa kwezidakamizwa kwiindawo zokuvuvukala kungaphunyezwa, kufuneke ukuba i-dosing engaphantsi kaninzi kunezinye iisjectables.
Emva kwesantya sokuqala, kukho ishedyuli yokulandelelana kwezimo.
I-Cimzia inokunikezwa ngezikhathi ezimbini okanye ezine iiveki-nokuba yedwa okanye nge-methotrexate.
Ukusebenza kweCimzia kwiimvavanyo zeZliniki
Iziphumo zesilingo ezinokuthi zenzeke kwiCimzia. Ucwaningo lwesigaba se-III lubonise inzuzo enkulu xa iCimzia isetyenziselwe yodwa okanye idibene ne-methotrexate kubantu abadala abane-arthritis esebenzayo (ie, synovitis esebenzayo ).
Ngokukodwa, isifundo se-FAST4WARD seveki ezingama-24 sibonise ukuba i-400 mg yeCimzia, inikwe iiveki ezingama-4 ngaphantsi, iyanciphisa kakhulu intlungu kunye nempawu kunye neempawu zesifo se-rheumatoid kunye nesimo somzimba esiphuculweyo xa kuthelekiswa nalabo be-placebo.
Izifundo zeRAPID zityhila inzuzo yokusebenzisa iCimzia kunye ne-methotrexate. I-RAPID1 ibonise inzuzo yexesha elide ekusebenziseni iCimzia ngokwempazamo yempawu, ukuphucula umveliso kunye nomgangatho wobomi, nokunciphisa ukukhathala. Ucwaningo lwesibini lweRAPID, olubizwa ngokuba ngu-RAPID2, lubonise ukuba iCimzia kunye ne-methotrexate kakhulu impawu kunye neempawu ze-rheumatoid arthritis, ukuqhubela phambili kwesi sifo, kunye nokusebenza komzimba okuphuculweyo kwizigulane ezine-arthritis esebenzayo.
Cimzia Side Effects
Iziphumo ezibi kakhulu ziye zaphuhliswa kwabanye abantu bathatha iCimzia. Ukumisela ulwazi olufumaneka kwiCimzia lumkisa malunga:
- Izifo ezinzulu, kuquka nesifo sofuba
- I-Cancer, kuquka i-lymphoma
- Iingxaki zenkqubo yeentlungu, kubandakanya i- multiple sclerosis
- Ukuphendulwa kwemizwa
- Iingxaki zegazi
- Ukutshaya kwenhliziyo okanye entsha
- Ukuphendula kwe-immune, kuquka ne-lupus-like syndrome
Iziphumo eziqhelekileyo ezichaphazelekayo ezichaphazelekayo neCimzia zizifo eziphezulu zokuphefumula, izifo zogcino, izilonda kunye, kunye neempendulo zendawo ye-injection.
Ngaba i-Cimzia FDA-Iyavunyelwa?
Ngo-Apreli 22, 2008, iCimzia yayivunyelwe i-FDA ukuba iphathwe ngokuthe ngqo kwi-Crohn yesifo esichukumisayo kubantu abadala abangakhange bancediswe unyango oluqhelekileyo. Ngo-Meyi 14, 2009, i-Cimzia yavunywa yi-FDA ukunyanga izigulane zabantu abadala ukuba zithintele ngokuthe ngqo kwi-arthritis esebenzayo. Iimpawu ziye zongezwa kwi- psoriatic arthritis kunye ne- spondylitis engavumelaniyo .
I-Cimzia ifumaneka kwisirinji esandulelayo ephethe i-Arthritis Foundation ye-Ease-of-Use Commendation. Uyilo lwesirinji luyisiphumo sobambiswano phakathi kwe-UCB kunye ne-OXO (eyaziwa kakhulu ngomgca wezinto zokupheka ze-ergonomic kunye nezinye izixhobo ezinomsebenzisi).
Imithombo:
Cimzia. Ukwazisa ngokugcwele. UCB. Uhlaziywa ngo-Apreli 2016.
http://www.cimzia.com/assets/pdf/Prescribing_Information.pdf
Cimzia. Guide Guide. UCB, Inc. Ukuhlaziywa ngo-Apreli 2016.
http://www.cimzia.com/assets/pdf/MedicationGuide.pdf