I-TNF Blockers - Ngaba izigulane zeArthritis ziyaba neengxaki zecala?

UkuHlola iingozi kunye neNzuzo

Izigulane ze-arthritis maxa wambi zivalo ngezinto eziphilayo , ezibizwa ngokuba yi-biologic response modifiers. Izidakamizwa zokuqala ze-biolog ezivunyiweyo yi-FDA zeentlobo ezivuthayo zesifo se-arthritis ziyizidakamizwa ezichasene ne-TNF , nazo zibizwa ngokuba yi-block block ye-TNF (tumor necrosis inhibitor). Kukho iziphumo ezinobungozi ezinxulumene ne-TNF blockers, ezifana nokusuleleka kwe-HIV kunye ne-lymphoma.

Kodwa, akufanelekanga yini ukulinganisela ingozi kunye neenzuzo zonyango nge-block blockers?

I-TNF blockers, ezibhekwa njenge-DMARD ye-biologic, ziquka i- Enbrel (etanercept), i- Humira (adalimumab), i- Remicade (infliximab), i- Simponi (golimumab) kunye neCimzia (certolizumab pegol). Bafumana inzuzo enhle kakhulu / mngcipheko. Ngamanye amagama, ngelixa iziphumo ezibi ziza kukhula, aziqhelekanga. Kwakhona kuyaphawuleka ukuba ezininzi izigulane zifumana uphuculo olubalulekileyo ekuthatheni iziyobisi.

I-block block ye-TNF iye yafundiswa kwizigulane kwiminyaka kwaye sele isemarike ukususela ngo-1998. Iinkxalabo ezimbini ezibalulekileyo ngala mayeza zibandakanya umngcipheko wokusuleleka kwintsholongwane okanye i-lymphoma. Ngaphandle kokuthatha i-TNF blockers, izigulane ze-rheumatoid arthritis zinomngcipheko wokwanda kwezi zimbini iingxaki (intsholongwane okanye i-lymphoma) xa kuthelekiswa noluntu jikelele. Enyanisweni, izigulane ezinesifo esibi kakhulu se-rheumatoid arthritis ziyakwazi ukuhlakulela i-lymphoma kunezo ezinezifo ezinzima.

Kukho ubungqina bokuba iziyobisi ze-biologic zandisa ingozi yokuvelisa izifo ezingavamile, ezifana nesifo sofuba (TB) . Ngako-ke, kucetyiswa ukuba zonke izigulane zihlolwe ngophando lwesikhumba kunye ne-x-ray esifubeni ukuze zihlolisise ukusukela kwi-TB ngaphambi kokuqala unyango nge-blocker ye-TNF.

Kufuneka uqaphele ngakumbi ngokuthatha ii-blockers ze-TNF ukuba unesifo seswekile esinesifo se-sululini okanye unesizathu esithile sokuba usengozini yokusuleleka kwintsholongwane, ukusuleleka kwezifo okanye izilonda ezivulekileyo okanye izilonda.

Izigulane ezininzi ze-rheumatoid zingenza kakuhle kwi- DMARD yendabuko, njenge- Plaquenil (hydroxychloroquine), i- Azulfidine (sulfasalazine) okanye i- Rheumatrex (methotrexate) kwaye ayinakuze ifune ukuthatha i-blocker ye-TNF. Kwizigulane ezinezifo ezibalulekileyo kwaye zinesizathu sokuba bangathathi i-methotrexate (umz., Isibetho sesibindi), ii-blockers ze-TNF zingasetyenziswa njengonyango lokuqala.

Ngaphantsi

Ukuba unikwe i-blocker ye-TNF kwaye uyavuma ukuzama, khumbula ukuba:

Umthombo:

Impendulo enikeziwe, ngokwengxenye, nguScott J. Zashin, MD uDkt. Zashin unjingalwazi oncedisayo ekliniki kwiYunivesithi yaseTexas Southwestern Medical School kunye noogqirha kwiiNgqungquthela zasePresbyterian zaseDallas nasePlano. UDkt. Zashin ungumlobi weArthritis ngaphandle kobuhlungu - Ummangaliso we-TNF Blockers kunye nombhali-mbhali we- Natural Arthritis Treatment .