I-Norrosis Factor Factor Yenza i-Inflammation
I-tumor necrosis factor (TNF) yinto eveliswa yiiseli kumzimba wakho wokuzivikela omzimba unempembelelo emininzi ekukhuthazeni inkqubo yokuvuvukala . Iveliswa ngokuyinhloko ngama-macrophage, uhlobo lweseli legazi elimhlophe, kodwa lingaveliswa ezinye iiseli ngokunjalo.
I-Norrosis Factor ejongene ne-Immune Response
I-TNF inxalenye yendalo yempendulo yomzimba yomzimba kwiintsholongwane zesisu, ibhaktheriya kunye neentsholongwane.
Idlala inxaxheba kokubili kwiimpendulo ezinzima kunye nokuvuvukala kwesistim. Amaseli akhululwa xa efumana into ethile (i-antigen) apho baye bayicetyiswa khona.
I-TNF yi- cytokine , iprotheni yokubonisa. I-Cytokines yimizimba yamachiza ehambisa imiyalezo phakathi kweeseli emzimbeni. Badlala inxaxheba kwiinkqubo ezininzi ze-biological, kuquka:
- Ukwanda kwamaseli
- I-Apoptosis, inkqubo eqhelekileyo yokufa kweseli
- I-lipid (inqatha) imetabolism
- Coagulation, okanye ukwakheka kwamacandelo egazi
I-Norrosis Factor kwiSifo
I-TNF inokuveliswa ngokugqithiseleyo okanye ngokungafanelekanga kwiinkqubo ezahlukeneyo zezifo. Oku kunokubangela ukuvuvukala okuqhubekayo kunye nezinye iimpawu eziwonakalisayo. Ezi zifo ziquka:
- Izifo ezizimela ngokuzenzekelayo ezifana ne-rheumatoid arthritis
- Ukuxhathisa kwe-insulin
- Cancer
I-Norrosis Factor ne-Rheumatoid Arthritis
I-tumor necrosis i-alpha-alpha yenye yeyona i-cytokines ebaluleke kakhulu echaphazelekayo kwi-rheumatoid arthritis ngokusebenzisa ukungena kwayo kwi-reaction of inflammatory reaction.
Ngokuqhelekileyo, umzimba ukhuba iTFF ngokwemvelo. Kodwa kwisifo se-rheumatic, ihlala isebenza kwaye idala ukuvutha okukhulu. I-block blocker ye-TNF yaphuhliswa ukulawula le mpendulo evuthayo.
I-TNF Inhibitor Izidakamizwa
Abantu abaneemeko zempilo ezinjenge- rheumatoid arthritis , i- psoriatic arthritis , kunye nesifo sika-Crohn singaphathwa nge-TNF inhibitor iziyobisi.
Ezi zi yobisi zibophelela kwi-tumor necrosis into-alpha, iyenza ingasebenzi. Oku kukuphazamisa umsebenzi wokuvuvukala kunye nokunciphisa umzimba wakho wokuzivikela. Kubantu abane-arthritis ye-rheumatoid, oku kunokunciphisa umonakalo odibeneyo. Iyeza lokuqala livunyiwe ngo-1998 kwaye ezininzi ziye zaphuhliswa. Bakho eklasini yeziyobisi ze- biologic , eziyimithi ejolise kwiimelelekyuli kwiiseli zamasosha omzimba.
Izidakamizwa ze-TNF inhibitor ziquka:
- Enbrel (etanercept)
- Remicade (infliximab)
- Humira (adalimumab)
- Simponi (golimumab)
- Cimzia (certolizumab pegol)
Ukusebenzisa i-TNF Inhibitors
I-block block ye-TNF ayithathwa ngomlomo. Endaweni yoko, kufuneka uyijobe phantsi kwesikhumba sakho okanye kwisisu sakho, ngokuqhelekileyo eselangeni lakho okanye esiswini. Ngokutsho kwemibiko yesigulane, utshintsho kwiimpawu zakho luqala ukuvela emva kokunyuka kwezimbini okanye ezintathu.
Ukuba ugqirha wakho uchaza i-blocker ye-TNF ejoyiweyo, uya kufundiswa indlela yokuyijoza ngokwakho ukuze ungabi nako ukuya kwiofisi yegqirha rhoqo.
Ukuba ugqirha wakho ubeka i-infliximab okanye i-golimumab, uya kufuneka ufike esikhungweni sokungena ngaphakathi okanye kwiofisi yegqirha ukuya kwiiyure ezintathu ukufumana unyango lwakho. La machiza ayenayo injectable.
Imiphumo emibi ye-Tumor Necrosis Factor Inhibitors
I-block block ye-TNF ingabangela iziphumo ezibi.
Eyona ndawo ixhaphakileyo yindlela yokusabela kwisayithi, ngokuqhelekileyo i-rash yendawo ehamba kunye novalo oluvuthayo okanye ukubetha.
Ingozi eyongeziweyo yazo zonke iintlobo zokusuleleka yiyona nto ibaluleke kakhulu yecala le-TNF kwiibhloko ze-TNF kuba zikhusela isistim somzimba wakho. Qinisekisa ukuba ugqirha wakho ukuvavanya ngesifo sofuba kunye ne-hepatitis B ngaphambi kokuqala unyango.
> Imithombo:
> Ulwazi malunga neTumor Necrosis Factor (TNF) Abagcini be-Blockers (Ukuthengiswa njenge-Remicade, Enbrel, Huma, Cimzia, nase-Simponi). US Food and Drug Administration.
> TNF Inhibitors. Ikholeji yaseMerika yaseRheumatology.
> I-TNF yokuLawula i-Necrosis Factor kubantu. Isiko seSizwe soLwazi lweBiotechnology.