Iimbangela zeThambo eliqhubekayo Ukuchithwa kweCarcer
Izilonda ze-osteolytic (ezibizwa ngokuba zizilonda ze-osteoclastic) ziindawo zokulimala kwethambo apho ithambo liye lanciphisa ngenxa yezibi ezifana ne- myeloma kunye nomhlaza wesifuba. Izilonda ngokwazo zibonakala njengezimbobo ezincinci kwi-X-ray. Abantu ngokuqhelekileyo babhekisela kubo njengokuthi "banokudliwa ngundu" okanye "ukukhangela".
Ukuphuhliswa kwezilonda ze-osteolytic kungakhokelela ekubuhlungu, ukunyanzeliswa kwentambo yomgudu, kunye nokwanda komngcipheko wesifo.
Unyango lubandakanya ukusetyenziswa kwamachiza okuthintela ukulahleka kwethambo kunye nokunyanga kwamayeza okunciphisa intlungu kunye nezinye iimpawu ezinxulumene nazo.
Iimbangela zezilonda ze-Osteolytic
Ifom ye-Osteolytic ifoni xa kukho ukungalingani kwenkqubo ye-biological ebizwa ngokuthi i-bone remodeling. Le yilapho iiseli ezindala kwi-skeleton zityhulwa kwaye zatshintshwa ngabantu abatsha. Ngethuba leentlobo ezithile zomhlaza, ezifana ne-myeloma, le nkqubo ingaphoswa kwinqanaba kunye nokuveliswa kweeseli ezintsha ezingakwazi ukuqhubeka nokulahleka kwabantu abadala.
Ngokubhekisele kwi-myeloma ngokukodwa, kukho izizathu ezininzi zokuba kwenzeka ntoni oku. Kukho uhlobo olulodwa lweseli elibizwa ngokuthi i-osteoblast ejongene nokwakha ithambo; enye enye i-osteoclast ekhupha izinto eziphula i-bone njengengxenye yenkqubo yokulungisa. Xa i-myeloma ihlasela izicubu zethambo, inqanda i-osteoblasts ngelixa ikhuthaza i-osteoclasts ukuba idibanise iiseli ngokukhawuleza.
Ziziphi iziphumo zokuhlaselwa kwezinto apho isalathisi sisoloko sifana nesofah.
Ukongeza kwi-myelomas, imbangela eqhelekileyo yezilonda ze-osteolytic yi-cancers metastatic (iintsholongwane ezazisasazeka ngaphaya kwesayithi se-tumor). Ezi ziquka i-metastatic cancers yeprotate, i-thyroid, imiphunga, iinjongo kunye nebele.
Izilonda zivame ukufumaneka kumathambo amakhulu, njengengqayi, umlenze, i-pelvis, i-ribcage kunye namathambo amakhulu emilenze.
Iziphumo zoMonakalo weThambo eMyeloma
Izifo zesithambo se-Osteolytic zingabangela iindidi zempawu kungakhathaliseki ukuba ngumhlaza ngokwawo. Phakathi kwabo:
- Iintlungu zesifo ziqhelekile kwaye zinokuba nzima kakhulu, zihlala zihamba kunye nomonakalo weentlungu kunye neentlungu ezibangelwa ukuxineka kwethambo
- I-osteoporosis (ukunyanzelisa kwethambo)
- Ukuphuka kwamathambo okubangelwa ngamathambo abuthathaka ngumhlaza
- I-hypercalcemia yesifo esithile apho amathambo aphulwa ngumhlaza wokukhupha i-calcium ephezulu ngokwegazi. Oku kunokukhokelela kwisisongela, ukuhlanza, ubuthathaka, ukudideka, i-myalgia (intlungu yesisu) kunye ne-arthralgia (intlungu edibeneyo). I-Arrhythmia (isantya sentliziyo engavumelekanga) yinto engavamile, ukuba, xa ishiywe ingaphatywa, ingaba yingozi.
Ukunyanga izilonda ze-Osteolytic
Izilonda ze-Osteolytic ziphathwa ngokudibanisa kwe-dose-radiation kunye ne- bisphosphonates , iklasi leziyobisi ezisetyenziswa ngabantu abane-osteoporosis. Ukuphinda (i-zoledronic acid) yenye yonyango echanekileyo esetyenziselwa umhlaza ukukhusela ukuqhuma kwezilonda zamathambo.
I-bisphosphonates inikwe i-intravenously malunga neeveki ezine. Imiphumo emibi ibandakanya umsebenzi wezintso ezincitshiwe kwaye, kwiimeko ezinqabileyo, i-osteonecrosis yomhlathi (apho ithambo lomhlathi liqala ukuhlakala).
> Imithombo
- > Bhutani, M .; Turkbey, B; I-Tan, E; okqhubekayo. "I-bone yomnkantsha engaqhelekanga kunye nezilonda zamathambo okuqala kwi-myeloma ezininzi kunye nesifo sawo sangaphambili: Umntu oza kufundisisa usebenzisa i-imaging esebenzayo kunye ne-morphologic." I-Leukemia neLymphoma . 2015: 57 (5): 1114-21.
- > Rajkumar, S. "I-Myeloma namhlanje: Iinkcazo zeengxaki kunye nophuhliso lwonyango." I-American Journal yeHematology . 2016. 91 (1): 90-100.
- > Reagan, M .; Liaw, L .; Rosen, C; et al "Ukuzibandakanya kwamandla phakathi kwethambo kunye ne-myeloma ezininzi: iindima ezikhulayo ze-osteoblast." I-Bone . 2015; 75: 161-9.