Isinyathelo sokuQala kwi-Diagnosis
Ukuvavanya isifo se-celiac phantse rhoqo kuqala ngeemvavanyo zegazi. Ezi mvavanyo zikhangele iimpendulo zomzimba wakho kwi- gluten , iprotheni efunyenwe ngqolowa, ibhalley, kunye neergu ebangela izifo ze-celiac.
Iimvavanyo zegazi azifezekanga. Ukuba iimvavanyo zakho zegazi ezingapheliyo zibi, kuthetha ukuba ungancitshiswa kakhulu ukuba ube nesifo se-celiac, kodwa kusekho ithuba elincinci lokuba unalo.
Ukuba iimvavanyo zakho zegazi zichanekile, kuthetha ukuba unako ukufumana isifo se-celiac, nangona uya kuhlala (kwiimeko ezininzi) kufuneka ufumane inkqubo yonyango ebizwa ngokuba yi- endoscopy ukuqinisekisa ukuxilongwa.
Ngelo xesha i-endoscopy, ugqirha wakho uza kufaka ityhubhu kwisisu sakho kwaye ube phezulu kwintumbu yakho encinane, kwaye uya kunqumla amasampuli amancinci emathunjini amancinci akho ukuba ahlole phantsi kwe-microscope. Ukuba ezi iisampuli zamathambo zibonakalisa i -atrophy ekhohlakeleyo , umonakalo wamathumbu emathunjini awuthola kwisifo se-celiac, ngoko unesimo.
Ewe, yinkqubo ende, kwaye iqala ngokuhlolwa kwegazi.
Ziziphi iimvavanyo zeGazi ezenziwa
Iimvavanyo zegazi ze-celiac zijonga iimpawu zokulwa nezifo ezibonisa indlela umzimba wakho omzimba ukuphendula ngayo kwi-gluten ekudleni kwakho-yingakho kufuneka udle gluten xa uvavanyelwa isifo esiqwengileyo. Ukuba awuyidli i-gluten ngexesha lokuvavanya, iimvavanyo zegazi ziya kuba zibi nangona unesifo esiyi-celiac.
Kukho iimvavanyo ezintlanu zegazi onokuzenza xa uvavanywa kwisifo se-celiac:
- I-AGA (antitigliadin antibodies) -IgA
- AGA-IgG
- I-TTG (i-anti-tissue transglutaminase) -IgA
- EMA (anti-endomysial antibodies) -IgA
- I-serum iyonke IgA
Ewe, bonke babonakala ngathi isobho se-alfabhethi. Kodwa zonke ezi mvavanyo zibukeka kwiindawo ezithile zesistim somzimba wakho wokuzivikela ukuze ubone ukuba umzimba wakho uphendula njani kwiprotheni ye-gluten ekudleni kokutya.
Kuzo zonke izi mvavanyo, uvavanyo lwegazi lwe-EMA-IgA lubhekwa uvavanyo oluchanekileyo lwegazi lwezilwanyana ezinqamlekileyo, oku kuthetha ukuba ukuba unemiphumo emihle kwi-EMA-IgA, unokuthi ube nesifo se-celiac. Nangona kunjalo, i-EMA-IgA nayo ingaphoswa abantu abathile abanezifo ezinqabileyo, ngakumbi ukuba sele baqale ukuphuhlisa imeko.
Ukuba unomdla kwiinkcukacha zobugcisa: I-EMA imele i-anti-bombingsial antibodies, eziyi-antibodies eziveliswa ngumzimba ezihlasela izicubu zomzimba. IgA, okanye i-immunoglobulin A, luhlobo oluqhelekileyo lwe-antibody oluveliswa ngumzimba wakho. Umsebenzi wayo kukunceda umzimba uqaphele kwaye ulwe nabahlaseli belizwe langaphandle njengee-toxins zendalo, ibhaktheriya kunye neentsholongwane.
Ezinye iiNzame eziCeliac
Uvavanyo lwegazi olubizwa ngokuba yi-AGA-IgA, AGA-IgG, kunye ne-TTG-IgA linokubonisa ukuba umzimba wakho uyayiphendula kwiprotheni ye-gluten ... kwaye inokwazi ukuchonga abantu abathile abanezifo eziqhekezayo eziqhelekileyo ezichanekileyo ze-EMA-IgA ephosakeleyo.
Nangona kunjalo, le mvavanyo iyakwazi ukuvelisa ezinye izinto ezibuxoki, apho apho uvavanyo lubuya khona nemiphumo emihle, kodwa loo mntu ayinayo isifo se-celiac. Yingakho ezinye iingcali zesifo se-ecliac zicebisa ukwenza zonke iimvavanyo-unokufumana umfanekiso opheleleyo ngakumbi.
Kwezinye iimeko, abantu abane-type 1 yesifo sikashukela, isifo se-thyroid , kunye nokuhlolwa kwesifo sesibindi esisigxina kwisinye sezi zivivinyo, vavanyo lweTTG-IgA, ngenxa yezinye iimeko. I-TTG imele i-transglutaminase ye-tissue, i-enzyme ngokuqhelekileyo ibonakala emathunjini.
Uvavanyo lwegazi oluhle lweTTG-IgA lubonisa ukuba umzimba udala ama-antibodies kwizicubu zawo, ezinokuthi zenzeke ekuphenduleni i-gluten ingestion. Nangona kunjalo, akusoloko kuthetha ukuba unesifo se-celiac, ngakumbi ukuba unenye yeemeko ezidweliswe. Ngoko ukuba unayo nayiphi na imimiselo, ugqirha wakho unokuthi ukhangele ngokuthe ngqo kwiziphumo zenye iimvavanyo zegazi ze-celiac.
Ekugqibeleni, iphaneli yokuhlolwa kwegazi i-celiac iquka uvavanyo olujonge ukuba uninzi lomntu olwaphilileyo, u-immunoglobulin A, umzimba wakho wenza. Oku kubalulekile kuba abantu abaphantsi kule nkunkuma (eyaziwayo njenge-IgA) banokuba nemiphumo emibi kwiimvavanyo zegazi ze-celiac, nokuba ngaba benesimo.
Kwaye, oku kubaluleke ngakumbi kuba abantu abanesifo esiqhwabayo bahluphekayo kule meko, eyaziwa ngokuba yi- IgA , abanamaxesha angama-10 ukuya kwezi-15 ngokuphindaphindiweyo kunabantu abemi.
Abanye oogqirha basebenzisa elinye le mivavanyo-i- antigliadin antibodies-IgG, okanye i-AGA-IgG -kubantu abanesicatshulwa sobubele obungenalo celiac. Nangona kunjalo, abaphandi baye babonisa ukuba ayilunganga ngokukodwa kuloo njongo, kwaye njengangoku, izazinzulu azizange zenze uvavanyo oluchanekileyo lobuthakathaka be-gluten.
Uvavanyo lweGene Celiac
Abanye oogqirha bancoma kwakhona ukuvavanywa kwamagciwane athile okwandisa umngcipheko wokuba nesifo se-celiac. Ukuba sele usuqalisile ukutya okungenayo i-gluten , oku kungakuvavanyo oluphela kuphela ugqirha wakho uncoma ukuba usebenze (iimvavanyo ezichazayo ngasentla azichanekanga ngaphandle kokuba udla gluten).
Iimvavanyo zegeni ze-celiac azibukeli i-antibodies ukuba i-gluten; Kunoko, bajonge iijethi ezimbini, i- HLA-DQ2 kunye ne- HLA-DQ8 , eziye zahlanganiswa nezifo ze-celiac. Izaziso zakho azitshintshi, nokuba udla i-gluten-free.
Ngoku, ukuvavanya kohlobo lweelliac oluthethileyo akuthethi ukuba unayo isifo se-celiac-ithetha nje ukuba unayo "ichanekileyo" zegciwane ukuze uhlakulele imeko. Ukuba ezinye iimvavanyo zakho zegazi zibi kodwa uvavanyo lwakho lwe-gene luyingozi, wena kunye nogqirha wakho unako ukugqiba isigqibo sokuthi ufanele ukuyeka ukudla ukutya kwe-gluten ngexesha lokuvavanya ukuze ubone ukuba nayiphi na impawu zeliliac disease ezicacileyo.
Imithombo:
I-Serologic kunye noVavanyo lweGenesis. Isiko seSifo seCeliac kwiziko lezonyango ze-Columbia University.
IYunivesithi yaseMaldinley Center yeCeliac Research. Izifo zeCeliac: Imibuzo ebuzwa rhoqo ngephepha lephepha