I-Autoantibodies iiprotheni eziveliswa ngumzimba wakho womzimba. Mhlawumbi uyazi ukuba isistim somzimba sakho senzelwe ukulwa nezinsongo ezifana neentsholongwane kunye neebhaktheriya ezenza indlela emzimbeni wakho. Kodwa i-autoantibody iphendulela ukuhlaselwa kwayo into engalunganga: Endaweni yokuhlaselwa ngabahlaseli belizwe langaphandle, ii-autoantibodies zihlasele ngokuphambene iinxalenye zomzimba wakho.
Xa besenza oku, i-autoantibodies ibangele ukuvuvukala kunye nomonakalo kunoma iyiphi inkqubo yomzimba eyenzekayo yokuhlaselwa. Lo monakalo ukhokelela kulokho esikubiza ngokuba " isifo sokuzimela " -kuthi, "auto" ithetha "uqobo." I-autoantibodies ivela ngaphambi kokuba iimpawu zesifo esicacileyo sibonakale.
Kutheni Umzimba Wakho Uyenza I-Autoantibodies?
Akucaci. I-Genetics ingaba nendima kule nkqubo, njengokuba yimiba engqongileyo. Kodwa abaphandi abazange baxelele ukuba kutheni abanye abantu abane-genetics efanayo kunye / okanye izinto ezifanayo zendalo ziqala ukwenza i-autoantibodies kwaye ziqhubeke nokuhlakulela isifo sokuzimela, ngelixa abanye bengenzi. Esi sifo se-celiac , umzekelo, umzimba wakho uphendule ukungena kwiprotheni ye -gluten ekudleni odlayo ngokudala ii-autoantibodies eziza kuhlaselwa umbane wesisu sakho esincinane.
Ngoku, uninzi lwabantu abanezifo ezilahlayo lithwala enye yeezityalo zegesi ezizibeka phambili kwiimeko.
Kodwa ezi zibizwa ngokuthi izifo ze-celiac zezifo ziqheleke kakhulu, kwaye kuphela iqhezu elincinci lalabo abanamajeni aqala ukwenza i-autoantibodies kwaye baqhubeke nokuhlakulela isifo se-celiac. Ngoko, ngokusobala kukho enye into edlalayo eyenza umzimba wakho uqale ukwenza ii-autoantibodies. Uphando luqhubeka ukufumana oko "into" ingaba yinto.
Yintoni Endifanele Ndiyayiyazi Ngama-Autoantibodies?
Ezinye i-autoantibodies zihlasela isilwanyana esithile-umzekelo, i-autoantibodies ekuhlaselweni kwezifo zeliliac emathunjini amancinci, ama-autoantibodies ekuhlaselweni kwesifo se-thyroid i-thyroid gland, kunye ne-autoantibodies kwi-type 2 yesifo sikashukela ehlasela iiseli ezivelisa i-insulin kwi-pancreas.
Ezi zixhobo ze-autoantibodies ezizodwa zikhokelela kwiimpawu ezicacileyo ezinokuncedisa ugqirha wakho ukuba enze uvavanyo oluchanekileyo. Ngokomzekelo, kukho eziliqela iimpawu zeengxaki ze-celiac ezibonakalayo, kodwa iimpawu eziqhelekileyo, ezibandakanya imiba yokutya kunye ne-anemia, inokunika inkcazelo yokuncedisa ukuxilongwa.
Ezinye i-autoantibodies zibizwa ngokuthi "inkqubo," oku kuthetha ukuba bahlasele kwiindawo ezahlukeneyo emzimbeni wakho. Ezi zinokubangela ezininzi iimpawu eziqhelekileyo, ezinjengeentlungu ezidibeneyo kunye neengqungquthela, ezenza imeko enzima kunzima ukuyifumanisa.
Ngokomzekelo, kunokuba kunzima ukuchazela umahluko phakathi kwe-auto-immune disease lupus kunye ne-fibromyalgia, oogqirha bakholelwa ukuba akusiyo imeko yokuzimela. Ukukunceda ukwenza ukuxilongwa, oogqirha banokuyilungisa iimvavanyo zegazi ezifuna i-autoantibodies ezibizwa ngokuba ngama-anti-nuclear antibodies, okanye i-ANA. Ezi zi-autoantibodies ezihlasela iinxalenye zeenuclei zeeseli zakho, kwaye phantse wonke umntu onayo i-lupus uya kuvavanya, abafanise nepesenti ezincinci zalabo abane-fibromyalgia.
Imithombo:
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Hu ZD et al. I-Autoantibodies kwisifo se-klinikhi yangaphambili. I-Clinica Chimica Acta: I-International Journal ye-Clinical Chemistry . 2014 uNgo-1; 437: 14-8.