Izaziso zakho zibalulekile, kodwa kunjalo ezinye izinto
Akucaci ngokucacileyo oko kubangela isifo se-celiac . Enyanisweni, abaninzi abaphandi bakholelwa ukuba kukho izinto ezininzi ezibandakanyekayo, zonke eziyimfuneko ukuba imeko iphuhlise.
Izahlulo zakho zidlala indima enamandla-ukuba awukho enye yezinto eziphilayo ezifakwe kwiingxaki ze-celiac, iingxaki zakho zokuphuhlisa imeko ziphantsi kakhulu (nangona zingekho zero).
Nangona kunjalo, inani elincinci labantu (malunga no-40%) lithwala enye okanye zombini kwezo zengqungquthela, ngoko ke ukuzalwa kwemvelo akuyena kuphela umdlalo owenzayo apha.
Ukuhlakulela isifo se-celiac, kufuneka udla i- gluten . Xa unesi sifo se-celiac, i-gluten inokukhusela isistim somzimba sakho sokulwa nomathumbu omncinci. Sekunjalo, i-gluten ixhaphake kakhulu kwiidlo zesidlo saseNtshona (abaninzi abantu badla i-gluten-kwaye baninzi ngokuphindaphindiweyo-amaxesha amaninzi ngalunye suku), kwaye i-1% kuphela yabantu bahlakulela isifo se-celiac.
Ekugqibeleni, ukuba uhlakulele isifo se-celiac, izinto ezinokusingqongileyo kufuneka zikuncede ukuzenza. Zizo "izinto" ezingacacileyo; Abanye abantu banokugcoba i-gluten imihla ngemihla bengenayo ingxaki baze bavelise iimpawu ezinzima zesifo se-ecliac ngokukhawuleza, ngelixa abantwana abancinci babonisa iimpawu eziqhambileyo ngokukhawuleza ukuba i-gluten-containing containing seeds is introduced into their diet.
Olunye uphando lubonisa ukuba intsholongwane efana nayo inokuthi, kubanye abantu, banegalelo ekuphuhlisweni kwesifo se-celiac.
Nangona kunjalo, isifundo siqala kwaye uphando olongezelelweyo lufunekayo ukuze kuphuculwe imiphumo eyiyo.
"Ukunyuka" kunokunceda ukuBangela iCeliac Disease
Abanye abaphandi baye baxilisa ukuba isifo se-celiac sidinga "intambo," enokuthi ithathe uhlobo lwezempilo okanye ukuxinzezeleka kwengqondo; Ngokomzekelo, abaninzi abafazi baqala ukufumana iimpawu zobunzima emva kokukhulelwa nokuzalwa, kwaye abanye abantu bafumana iimpawu zabo baqala ukulandela isifo esibonakala singathandaniyo, okanye silandela ixesha elixinzelelekileyo ebomini babo .
Nangona kunjalo, le "nyilo" yeengcamango ihlala ingavunyelwe.
Ezinye izazinzulu zicinga ukuba i-gluten yimihla yokutya-eyakhulile kakhulu kwiminyaka engama-40 edlulileyo, kokubili njengoko sidla iimveliso zengqolowa ezininzi kwaye njengengqolowa ngokwayo iqulethwe ukuba ibe nezinga eliphezulu le-gluten-lingabangela uxanduva lokubangela ezinye iimeko zesifo se-celiac. Kukho ubungqina obunjalo malunga nale ngcamango, kuba uphando olutshanje lufumene ukuba iziganeko zesifo se-celiac sele ziphindwe kabini emva kweminyaka emi-15 ukususela ngowe-1974.
Kanti abanye bajolise kwisifo se-celiac kwi-molecular level. Uphando olutshanje lufake izibonakaliso ezimbini zamakhemikhali-interleukin 15 kunye ne-retinoic acid, i-derivative ye-vitamin A-njengabaqalile ukuphendula impendulo yomzimba ku-gluten. Abaphandi bajonga abantu abane-diagnosis ye-celiac, kwaye bafumanisa ukuba banamanqanaba aphezulu e-interleukin 15 emathunjini abo. Xa bekhupha amanqanaba aphezulu kuloo khemikhali kwiigundane, amagundane avelise iimpawu zakuqala zesifo se-celiac. I-retinoic acid yonakalisa iimpawu kunye nomonakalo.
Xa abaphandi banqamle i-interleukin 15, ke ke, iigundane zibuyele kwizinto eziqhelekileyo kwaye zakwazi ukunyamezela i-gluten kwakhona. Oku kukhokelela oososayensi ukuba bacacise ukuba amazinga aphezulu e-interleukin 15 emathunjini akho angabangela isifo se-celiac.
(Kakade, kusenakucaca oko kunokubangela ukuba amazinga aphezulu e-interleukin 15 aphuhlise emathunjini akho.) Sekunjalo, ukuba kunjalo, imishanguzo evimba i-interleukin 15 (ekhoyo esele iilingo kwizigulane ze-rheumatoid arthritis) inokukunceda baphathe isifo seliliac.
Unxibelelwano olunokwenzeka phakathi kweCeliac neReovirus?
Iingcali zenzululwazi ziye zachonga inxibelelwano ekhoyo phakathi kwesifo se-celiac kunye nohlobo lwegciwane elibizwa ngokuba yi-reovirus. I-Reovirus iyathintela abantu abaninzi, ngokuqhelekileyo xa beyiintsana, kodwa kubangela ezimbalwa okanye akukho mpawu. Uphononongo olushicilelwe kwiphephancwadi leSayensi , lusetyenziswe iigundane ezabethelwa ngokukhethekileyo ukuba zibe neengxaki zesifo se-celiac.
Abaphandi bafumene iimpendulo ezinamandla ezikhuselwane ne-immune system kulezo iigundane xa besuleleke yi-virus kwaye bondla i-gluten.
Abaphandi baphinde bahlalutya abantu abaye bafumanisa ukuba banezifo eziqhekezayo, bejonga ngokuthe ngqo i-antibodies kule ntsholongwane. Bafumene amanqanaba aphakamileyo amaninzi e-reovirus antibodies kubantu abanama-celiac-amabini amahlanu aphakamileyo kunabantu abangenawo imeko.
Olu phofu alusondeleyo ekubonakaliseni i-reoviruses imbangela-okanye nokuba nesifo se-celiac. Abaphandi baya kufuna ukuqhuba izifundo ezongezelelweyo ukuze babone ukuba ikhonkco inamathela. Nangona kunjalo, ukuba ii-reoviruses zenza igalelo ekuphuhlisweni kwesifo se-celiac, kungenzeka ukuba isitofu sokugonya singancedisa abantu abaneentsholongwane.
Isizathu seSifo seCeliac Asisayi kucaca, nangona uphando
Ngoko ukuqokelela, isifo se-celiac sibangelwa ngu: ukufumana izakhi zofuzo ezifanelekileyo, ukutya i-gluten, kwaye mhlawumbi ngohlobo oluthile lwe-trigger.
Enye imfundiso engacacile yinto ethandwayo ekugxeka ukunyuka kwezifo ezingenanto kunye ne-non-celiac i-gluten enobubele kwimbewu yengqolowa eguquliwe. Ekubeni ingqolowa eguqulwe ngokwemizimba ayikho kwimarike naphi na, ayikwazi ukubangela ukwanda .
Nangona kunjalo, inzululwazi yezokwelapha ayayazi ngokubanzi malunga naziphi na izinto ezinokubangela, nangona ezo zibonakala zibalulekileyo ukuba kutheni abanye abantu abanegciwane "elungileyo" behlakulela isifo se-celiac xa abanye bengenzi. Enyanisweni, abaphandi baye baqala ukuhlola iindlela ezahlukeneyo. Kusenokwenzeka nokuba, kukho nezinye izakhi zofuzo ezibandakanyekayo ezingazange zichongwe.
Akungathandabuzeki, nokuba kunjalo, ukuba isigqibo sesifo se-celiac sinokukunceda ukukhawuleza uphuhliso lweyeza-based treatment. U-Alessio Fasano, MD, umlawuli we-University of Maryland ye-Mucosal Biology Research Centre kunye neZiko loPhando lweCeliac, uthi uphando malunga nokuba kunokusingqongileyo kwimeko yesifo esiqakathekileyo kubaluleke kakhulu-ukufumanisa izizathu zesifo se-celiac kunokunceda ukudala unyango lwe-celiac okanye thintela imeko ngokupheleleyo.
Imithombo:
Bouziat R et al. > I-Reovirus Infection Inokubangela izimpendulo zokuzikhusela kwiAntigens zeNtlobo kunye nokuPhuhliswa kwezifo zeCeliac. Sayensi . 2017 kuMatshi 7; 356 (6333): 44-50.
UCatassi C. et al. Imbali yemvelo yesifo se-celiac kwisigxina sase-USA salandelwa ukususela ngowe-1974. Ama-Annal of Medicine. Oktobha 2010, iphe. 530-8.
IYunivesithi yaseCichiac Celiac Disease Centre. Iimpawu.
KwiYunivesithi yaseChicago News. Uphononongo lwabantu kunye nemigxininisa lujolise ekugxininiseni imbangela yesifo se-celiac.
IYunivesithi yaseMary School School of Medicine News. IYunivesithi yaseMadrid Centre yeCeliac Research Ithola ireyithi yezifo zeCeliac ikhula.