Ingaba I-Cancer Cancer Inherited?

by Lynne Eldridge, MD

Ukuba umntu Ohlala Kwintsapho Yami Unomdlavuza, Ngaba Ndiyakwazi Ukufumana?

Kuyaziwa ukuba ezinye iintsholongwane, ezifana nesifo somhlaza we-ovari kunye nomdlavuza wekolon, ziqhutywa kwiintsapho. Nangona indima yobunzima emdlalweni wemiphunga ayengaziwa, ukuba imbali yentsapho yomdlavuza wamaphaphu inokwandisa umngcipheko kwinqanaba elithile. Umdlavuza wamaphaphu uphezulu kwabasetyhini, abangaboniyo kunye nalabo abanomdlavuza wamaphaphu ekuqaleni (umhlaza wamaphaphu owenzeka ngaphambi kokuba uneminyaka engama-60).

Ngokubanzi, kuqikelelwa ukuba i- 1.7 ekhulwini yamanqatha emaphaphu ukuya kwi-68 ifa. Imiba emininzi inxulumene nomhlaza wesifo somphunga, kuquka:

Iliphi ilungu leNtsapho lihambelana

Ukuba nelungu lentsapho yokuqala (umzali, umntakwabo okanye umntwana) ngomhlaza wemiphunga, ubuyaphinda ibe nomngcipheko wokuba nomdlavuza wamaphaphu. Olu mngcipheko luba ngaphezu kwabasetyhini kwaye bancinci kumadoda kwaye banamandla kunabanye abantu ababhemayo. Ukuba nesihlobo sesibini (unina, umalume, umntakwabo okanye umtshana) nomhlaza wamaphaphu uphakamisa umngcipheko wakho malunga neepesenti ezingama-30 .

Isimo sokutshaya, umdlavuza weLung, kunye neHeredity

Ababhemayo abahlakulela umdlavuza wamaphaphu abanamathuba amaninzi okuba nembali yentsapho kunokuba bangaboniyo ababa nomdlavuza wamaphaphu. Le nto yathi, nangona kunjalo, kulabo abanesifo somhlaza kwimiphunga yamaphaphu, ukutshaya kubonakala kukukhuthaza loo mngcipheko.

I-Cancer Cancer kwi-Non-Smokers

Uhlobo lwe-Lung Cancer kunye neHeredity

Izifundo ziyahlukahluka kwiindidi zamanqamu emiphunga anesigxina esikhulu , kodwa abo abanomdlavuza wamangqamuzana omnxeba , ikakhulukazi imiphunga ye-lung adenocarcinoma banakho amathuba okuba nomnwazi wentsapho yomdlavuza wamaphaphu kunabo abanomdlavuza wamancinci wamangqamuzana .

Ukufunyanwa kwangoko kukuba abantu abangabhemi abanomdla wesifo somhlaza wamangqamuzana ongeyonto encinci, ukuba izidumbu zine- EGFR ukuguquka komninzi kunomdla wentsapho yomdlavuza wamaphaphu kunabo abanokuguqulwa kwe- ALK okanye ukuguqulwa kwe-KRAS.

I-Genetic Breast Cancer (BRCA2) kunye neengozi yeMhlaza yeLung

Kungekudala kuye kwafunyanwa ukuba abantu abanokuguqulwa kwe-BRCA2 - enye yenguqu efunyanwa ngabantu abanomdlavuza we- genetic breast - basengozini enkulu yokuphucula umdlavuza wamaphaphu.

Olu tshintsho lufumaneka kwipesenti e-2 yoluntu lwaseYurophu kwaye luzuze kwifa le-autosomal. Ukongeza ukwandisa umngcipheko wesifo somhlaza kunye nomhlaza wesibeleko (phakathi kwabanye), ababhemayo kunye nokuguqulwa kwamanzi baye bafumana phantse kabini amathuba okuba nomdlavuza wamaphaphu. (Umngcipheko womhlaza wamaphaphu wawuphezulu ngaphezu koqhelekileyo kubantu abangafuni ukutshaya.) Ababhemayo abathwala ukuguqulwa komzimba kubonakala benomngcipheko okwandisiweyo ngokukodwa kumhlaza wesifo somhlaza wamasipha , uhlobo lomhlaza wesifo somhlaza wamangqamuzana. Ngeli xesha, akukho ziphakamiso ezithile malunga nokuhlola abantu abanokuguqulwa, kodwa abo bachaphazelekayo banqwenela ukuthetha namagqirha abo malunga nokuhlolwa kwe-CT yomdlavuza wamaphaphu.

I-Cancer Cancer ehlanganiswe ne-Genetic Breast Cancer (BRCA2)

Uhlanga, umdlavuza weLung, kunye noHeredity

AbaNtsundu abanezihlobo ze-first-degree banomngcipheko omkhulu wokuqala umdlavuza wamaphaphu kunabamhlophe. Lo mngcipheko ukwanda kwabashushu.

Ezinye i-Cancer kunye neHerederal Lung Cancer

Ngokubanzi, ukuba nembali yentsapho yeekhensi ngaphandle komdlavuza wamaphaphu ayibonakali ukwandisa umngcipheko wokuba uhlakulele umhlaza wamaphaphu. Ngakolunye uhlangothi lwe-equation, nangona kunjalo, abo bahlakulela ngaphezu komnye umdlavuza wamaphaphu oyimfuneko kakhulu banokuthi babe ne-genetic predisposition echaphazela umhlaza wabo.

Yintoni endiyenzayo ukuba ndiyenze xa ndifumana Imbali Yentsapho Yengculaza Yengwenya?

Ukuhlolwa kwe-CT yomdlavuza wamaphaphu kukukhetha kwabanye abantu, nangona okwangoku kunconywa ngabo bantu abaphakathi kweminyaka yobudala engama-55 no-74, abatshitshisa okanye bayeka kwiminyaka eyi-15 edluleyo, kwaye banomdla we- pack ukutshaya. Ngokuxhomekeke kwimingcipheko yakho, wena kunye nodokotela wakho ukhetha ukhetho lokukhetha ngaphandle kwamaparitha. Ngaphambi kokuba sithembeke malunga nezo jeni ezinikezelwe nguMama noTata, kufuneka sihlale sikhumbula ukuba izimbangela ezininzi zomhlaza wamaphaphu zikhuselwe. Ukuyeka ukutshaya (ukuba utshaya), ukuvavanya ikhaya lakho nge- radon , ukutya ukutya okunempilo , ukuzisebenzisa nokunyamekela ukukhusela izizathu zokusebenza kunokuncedisa umngcipheko wakho wokuba nomdlavuza wamaphaphu nokuba unembali yentsapho okanye cha.

_Imithombo:

_{Albright, F. et al.} _{Ubungqina obubalulekileyo malunga negalelo elifanelekileyo kumdlavuza ongaphambili: ukuhlaziywa komhlaza wesizwe kwindawo.} _{BMC Cancer .} _{2012. 12 (1): 138.}

_{Cote, M. et al.} _{Umngcipheko wokwanda komdlavuza wamaphaphu kubantu abaneentsapho zembali yesifo: Uhlalutyo oluhlanganisiweyo oluvela kwi-International Lung Cancer Consortium.} _{I-European Journal yeCarcer .} _{2012 uMatshi 19. (Epub ngaphambi kokuprinta).}

_{Cote, M. et al.} _{Umngcipheko womhlaza wamaphaphu phakathi kwezihlobo ezimhlophe kunye ezimnyama zabanye abanomhlaza wesibeleko.} _{Umbhalo we-American Medical Association .} _{2005. 293 (24): 3036-42.}

_{Gaughan, E. et al.} _{Imbali yentsapho yomdlavuza wamaphaphu angabikho ababhemayo kunye nomhlaza ongaselula-umlenze wamaphaphu kunye nokudibanisa kunye nezicubu ezinokuguquka kwe-EGFR.} _{Cancer Lung .} _{2013. 79 (3): 193-7.}

_{Hemminki, K., kunye neX. Lix.} _{Umngcipheko oqhelekileyo womdlavuza wamaphaphu nge-histology kunye nobudala bokuqala: ubungqina belifa elingapheliyo.} _{Uphando lweLung lwengqondo .} _{2005. 205-15.}

_{Jonsson, S. et al.} _{Umngcipheko oqhelekileyo womdlavuza wamaphaphu kubemi base-Icelandic.} _{Umbhalo we-American Medical Association .} _{2004. 292 (24): 2977-83.}

_{IsiXhosa, X., no-K. Hemminki.} _{Amanomdla aphezulu amachiza ephambili yamapayipi: isisombululo esisekelwe ngabantu esivela eSweden.} _{Cancer Lung .} _{2005. 47 (3): 301-7.}

_{IsiXhosa, X., no-K. Hemminki.} _{Izabelo eziza kuzaliswa kwintsholongwane yokuqala yomdlavuza wamaphaphu ngokulandelelana nohlobo lwakhe.} _{Journal International of Cancer .} _{2004. 112 (3): 451-7.}

_{Nitadori, J. et al.} _{Umbutho phakathi kweengxaki zomhlaza wemiphunga kunye nomlando wentsholongwane yomhlaza: idatha evela kwisifundo esiphezulu sabantu-based study, i-JPHC.} _{Esifubeni .} _{2006. 130 (4): 936-7.}