Ukuhlanganiswa kwamaBhaktoni weeLungs ngeCystic Fibrosis
Kusenokwenzeka ukuba uye wakuva malunga nekhontoni ye-bacterial colonization ukuba uhlala ne-cystic fibrosis. Ithetha ntoni le nto?
Yintoni iColonization?
Ikholoni iyenzeka xa ii-microorganisms zihlala okanye zihlala kwindawo enomdla kodwa zingangeni emathisini okanye zenze umonakalo. Iikholoni ibhekisela kubukho bezinto ezincinci ezinokubangela ukusuleleka, kodwa kungekhona kwintsholongwane ngokwayo.
Nangona ezi zixhobo ezincinci zikhoyo, kunjalo, ukwandisa umngcipheko wokusuleleka ukuba unobungozi obufanelekileyo.
Kubaluleka koKoloni kwiCystic Fibrosis
Abantu abane- cystic fibrosis (CF) bahlala bekholonike ngeebhaktheriya, ngakumbi kwi-mucus kunye ne-airways. Ukuba izinto eziphilayo ziqala ukuhlasela izicubu kwaye zidale umonakalo okanye zenze umntu agule, ikholoni iba yintsholongwane.
Utshintsho lweeNtsholongwane zokuphefumula kubantu abaneCystic Fibrosis
Kubantu abanesifo se-cystic fibrosis, ukukhutshwa ngokweqile kwe-muscus kunye nokusuleleka kwebhaktheriya okungapheliyo kubangela uhlobo olukhethekileyo lwesifo esingapheliyo se-pulmonary disease. Abantu abane-cystic fibrosis ekugqibeleni bahlakulela i- bronchiectasis apho i-airways ibonakaliswe kakubi kwaye ibonakala.
I-Bronchiectasis yimeko apho i- bronchi ne- bronchioles (amasebe amancinci e-airways) ayancipha, avuliwe kwaye anqabile. I-Mucus iqokelela kule mijelo yomoya ekhutshwe phambili yokusuleleka kwintsholongwane.
Usulelo luya kubangela ukwanda, ukukhulisa, kunye nokukhawulwa kweenqwelo-moya eziphinda umjikelezo ononya.
Ngaphandle kwe-bronchi kunye ne-bronchioles i- alveoli , iifoksi ezincinci zomoya apho kukho utshintshi lwe-oxygen ne-carbon dioxide. Xa i-bronchioles ekhokelela kule mizila encinci ye-airways ilahlekelwa yintambo yokuxhoma (ukusuka kunye nobunzima) kwaye igqitywe nge-mucus, i-oksijini ephawulwe emiphakeni ayikwazi ukufikelela kwi-alveoli ukuze utshintshiselwano lwegesi lwenzeke.
Kutheni Imimungwane Eyabantu NgeCystic Fibrosis Ivelisa i-Mucus excess?
Akukucaci ukuba ngaba abantu abane-cystic fibrosis ekuqaleni bavelisa i-mucus e-viscid engaphezulu okanye benze njalo ngenxa yekoloni. Nangona kunjalo, ukuhlolwa kwemiphunga kwiintsana ezisanda kuzalwa kunye ne-cystic fibrosis abangasayi kubakholwa ne-bhakteria kubonisa ukuveliswa kwemveliso ye-mucus. Ezi ziphumo zibonisa ukuba i-muscus ibangela abantu abane-cystic fibrosis ukuba i-colonization ne-bacteria.
Ziziphi iintlobo zeBhaktheriya eziQolisa iiLungs zabantu abaneCystic Fibrosis?
Zininzi iintlobo zebhakteria ze-aerobic (iibhaktheriya ezikhula phambi kwe-oxygen), ibhaktheriya ene-anaerobic (ibhaktheriya ekhula ngaphandle kwe-oksijeni) kunye nezifo ezinomdla ezinjenge-fungus i-colonize imiphunga yabantu abane-cystic fibrosis. Ixesha elifanelekileyo lokusetyenziswa kwezilwanyana ezinokuthi lilungele ukuchaza ama-microorganism ezingabangela ukusuleleka kubantu abasempilweni kodwa zingabangela ukusuleleka xa "ithuba" livela, njengokuba isifo sesifo se-lung.
Nazi ezinye iilwanyana ezenza iipoloni zabantu abane-cystic fibrosis:
- Pseudomonas aeruginosa
- Staphylococcus aureus (kuquka i- MRSA )
- Escherichia coli
- Haemophilus influenzae
- Klebsiella
- Prevotella
- Propionibacterium
- Veillonella
- U-Aspergillus (funda nge-bronchopulmonary aspergillosis kubantu abane-cystic fibrosis)
Uninzi oluqhelekileyo lwee-Pathogens ezenza iColonize Airways kubantu abakwiCF
Kule mibhalo engentla, ukoloni kunye ne-Pseudomonas ngokuqhelekileyo kwaye i-80 ekhulwini yabantu abadala abane-cystic fibrosis bahlonyelwa ngoluhlobo lweebhaktheriya.
Izixhobo eziMelana neMidrrug-Resistant kunye neCystic Fibrosis
Ukongeza kwimizimba engasentla, abantu abane-cystic fibrosis banokuthi bahlonywe nge "superbugs" okanye izinto ezinokumelana neziyobisi . Izidalwa ezinokumelana nezidakamizwa (izilwanyana ezingamelana nemithi eminingi ye-antibiotics) zibamba emiphakeni yomntu one-cystic fibrosis ifumana unyango lwe-antibiotic ye-infections, njenge-Pseudomonas.
Ukoloni kunye nokusuleleka kwezilwanyana ezinokungaxhatshazwa ngamachiza kuyatshwenyeka ngenxa yokuba le mizimba iyanqanda unyango ngamayeza aqhelekileyo.
Kutheni i-Colonization nePseudomonas iQinisekisa?
Iingcali zineengcinga ezininzi okanye zicinga ukuba kutheni iimiphunga zabantu abane-cystic fibrosis zikholiswe kakhulu kunye ne-Pseudomonas, kubandakanywa oku kulandelayo:
- Ukunciphisa ukuxoxwa kobuxhakaxhaka kunye kunye nokungasebenzi kweepraptides antibacterial
- Ukukhuseleka kwemiphunga ngenxa yemigangatho ephantsi ye glutathione ne-nitrous oxide
- Ukunciphisa ukungena kweebhaktheriya ngamaseli emiphunga
- Inani elininzi lama-receptors
Asizi kakuhle ukuba zeziphi iindlela ezibaluleke kakhulu ekumiseni ukoloni lwePseudomonas. Nangona kunjalo, kuyacaca ukuba emva kokuba iPseudomonas ithatha, ukusuleleka kwintsholongwane engapheliyo iqhubeka.
Abantu abane-cystic fibrosis abakholiswe nge-Pseudomonas bafuna unyango lwe-day care kunye ne-antibiotic anti-antibiotics xa unyango lubekwe. Ngelishwa, nangona unyango olunjalo, ukusuleleka kwe-Pseudomonas kubangela ukulahlekelwa ngumsebenzi wamaphaphu kwaye kukhokelela ekufeni kwabantu abaninzi nge-cystic fibrosis. Funda kabanzi malunga nePseudomonas kubantu abane-cystic fibrosis .)
Imithombo
UBoutin, S., noAlppke. Ukuzuza kunye nokulungelelaniswa kwe-Airway Microbiotia kwi-Early Life ye-Cystic Fibrosis Iziguli. I-Molecular and Cellular Pediatrics . 2017. 4 (1): 1.
Huang, Y., noJiPuma. I-Microbiome kwiCystic Fibrosis. Uncedo lweNtsholongwane . 2016. 37 (1): 59-67.
Jonga JA, Mascarenhas M, Kelly A, Scanlin TF. Icystic fibrosis. Ku: I-Grippi MA, uElias JA, i-Fishman JA, uKotloff RM, i-Pack AI, uMasipala oyi-Senior, uSiegel MD. eds. I-Fishman's Pulmonary Diseases and Disorders, I-5 yesiHlomelo . New York, NY: McGraw-Hill; 2015.