I-Pseudomonas Aeruginosa ixakeke kakhulu kubantu abaneCF
Ama-60% abantu abane- cystic fibrosis banesifo esingapheliyo sokuphefumula esibangelwa ibhaktheriya ebizwa ngokuthi iPseudomonas aeruginosa. Le bhaktheriya ihlala kwi-mucus enqabileyo eboshelwe kwi-airways. Emva kokuba iPseudomonas aeruginosa ihlasele umzila wokuphefumula, kunzima ukulahla. Ukungaphumeleli kokuphefumula okubangelwa usulelo kuyona nto ibangela ukufa kubantu abaninzi abaneCF.
Ibhaktheriya i-Pseudomonas aeruginosa ihlala kuyo yonke indawo. Le bhaktiriya ikhona kwiindawo ezinomanzi ezinjengeenxa yomhlaba, izityalo, izitya, iimvula kunye nezicathulo zeenwele zeenennis. Uninzi lwabantu luhlangana nePseudomonas aeruginosa nsuku zonke ngaphandle kokusuleleka. Nangona kunjalo, kubantu abangenakho ukuxilongwa okanye abantu abanokuphuka kwesikhumba okanye kwiimbumba ze-mucus, le bhaktiriya ingabangela ukusuleleka.
Ukongezelela ukusulela abantu abane-CF, i-Pseudomonas aeruginosa ichaphazela amaxhoba atshisa kakhulu kunye nezigulane ezifumana i- chemotherapy . Kwiminyaka yakutshanje, iziganeko ze-Pseudomonas aeruginosa isifo ngenxa yezizathu ngaphandle kweCF sehlile; kanti, isiganeko sentsholongwane phakathi kwabantu abane-CF asizange sitshintshwe.
I-Pseudomonas Aeruginosa ithathwa njani?
Kwiminyaka edlulileyo, i-Pseudomonas aeruginosa engapheliyo kubantu abaneCF ayiphathwe ingaphumelelanga ngamayeza omlomo okanye inyulo ye- antibiotic .
Ngasekupheleni kwee-1990 ii-antibratiy tobramycin, okanye i-TOBI, yaveliswa ngokukodwa kwonyango yokuphefumula okungapheliyo Pseudomonas aeruginosa. I-TOB ingoku unyango oluqhelekileyo lwale ntsholongwane kwaye yimiyeza echazwe ngokuqhelekileyo kubantu abane-cystic fibrosis.
Yintoni i-TOBI?
I-TOB iyenziwe i-tobramycin. I-Tobramycin iyi-anti-antibiotic yaminoglycoside esetyenziswa ukuphatha i-Pseudomonas aeruginosa isifo. Le antibiotic isebenza ngokusasaza ngeprotheni yeprotheni. Ngokugqithisa kunye neprotein ye-Pseudomonas aeruginosa, i-TOBI iphazamise umlenze we-bacterial membrane kunye nemvulophu ngaloo ndlela ibangela ukufa kwesisele.
Yintoni i-TOBI Podhaler?
I-TOBI yayisetyenziswa ngokusemthethweni isebenzisa i- nebulizer . I-nebulizer ngumatshini ovelisa umhoxo omhle ngokuphalaza. Ngo-2013, i-FDA ivunyiwe i-TOBI Podhaler, eyona nto i-powder inhaler eyomileyo ezele i-tobramycin eyomileyo. Amachiza amatsha enza kube lula isigulane ukuthatha i-tobramycin
Ngaba i-TOBI wonke umntu?
Ngelishwa, i-TOBI ayilona wonke umntu. Abantu abaneengxaki zokuva, iingxaki zeengtso, kunye neengxaki ze-neuromuscular kufuneka zibekwe i-TOBI ngokucophelela. Ngokukodwa, i-aminoglycosides iyaziwa ngokutshabalalisa ngeentlebe, izintso kwakunye nokwandisa izifo ze-neuromuscular ezifana ne-myasthenia gravis. Ukongezelela, abantu abane-hypersensitive ("allergic") kwiiminoglycosides akufanele bathathe i-TOBI. Ekugqibeleni, i-tobramycin, eyona isithako esisebenzayo kwi-TOBI, i-teratogen kwaye ingabangela ingozi kumntwana okhulelweyo kubhinqa abakhulelweyo.
Umthombo:
USmith, AL "Unyango lwe-Antibiotics: Inyiphi imithi? Yiyiphi iDose? Yiyiphi imimiselo? Yiyiphi iFomation? "I- Journal yeCystic Fibrosis . 2002 1: S189-S193. 22 uJuni 2008.
Ramphal R. Izifo ngenxa yeePseudomonas zeeNdidi kunye neziNxulumaniso eziHlangeneyo. Ku: Kasper D, Fauci A, Hauser S, uLongo D, Jameson J, Loscalzo J. eds. Iinqununu zeHarrison ze-Internal Medicine, 19e . New York, NY: McGraw-Hill; 2015.