Ukuqhubela phambili kuPhando lweBioogenetic kwandisa iiNkalo zoBomi
I-Cystic fibrosis (CF) yintlupheko eqhubekayo echaphazela umgangatho wobomi kunye nobude bobomi kulabo abaphila nesi sifo. Ngoxa i-technically isifo esingabonakaliyo (esichaphazela abantu abangama-30,000 kuphela e-US), isacinga nje enye yeengxaki zokusabalalisa ezithintekayo zobomi.
Ngoxa ixesha lokuphila kwabantu abaneCF lihlala lingaphantsi kwelo lilonke labantu, ukwandisa ulwazi malunga nesi sifo, kunye nokunyanga okunyanga , sele kuqalile ukuguqula izinto.
Ubomi obulindelekileyo Uzuze kubantu abaneCystic Fibrosis
Ngowe-1938, xa i-CF ibonwa kuqala njengesifo, ezininzi iintsana ezixilongwe ngengxaki ziyafa ngaphambi kokuzalwa kwazo kokuqala. Ngama-1950, abantu abane-CF bahlala ixesha elide kodwa bekunqabile ukuba benze ukuhamba ebuntwaneni. Nangona izinto zaqala ukuphucula ngama-1980, xa abantu ngoku bahlala phakathi kwabo ukuya kwiminyaka eyi-20, bekungekho ukufumanisa i-CFTR gene ngo-1989 ukuba saqala ukubona ukujika.
Namhlanje, zixhobile ukuqonda okungcono impawu zofuzo zeCF, sinendlela yokuphatha kakuhle isifo, ukuthintela ukusuleleka, nokuphucula umsebenzi wamaphaphu kulabo abaphila neengxaki.
Ngenxa yoko, ithuba lokuphila lobomi labantu abahlala neCF namhlanje liyiminyaka eyi-37.5. Kwilizwe elithuthukileyo, loo mfanekiso iphakamileyo kunye nokuqikelelwa okuphakathi kwimizuzu engama-42 ukuya kuma-50.
Ngokuphuculwa kwonyango kunye ne-biotechnologies, abaphandi baqikelela ukuba iintsana ezizalwe namhlanje zingakwazi ukuhlala kakuhle ngaphaya kokuzalwa kwazo ezingama-50.
Ukwandisa iiMpilo zoLuntu ezixhamene nokusetyenziswa kweeNtsholongwane
Phantse iipesenti ezingama-80 zabantu abane-cystic fibrosis baya kuba nosulelo lwe- Pseudomonas aeruginosa , iibhaktheriya eziqhelekileyo zijonga ukusabalalisa okubanzi kwiplanethi.
Abantu abaneCF banomngcipheko omkhulu kakhulu weP. aeruginosa , ukusuleleka oko kungaholela ekupheleleni ukuphefumula kwanokufa.
Enyanisweni, ama-50 ekhulwini labantu abaneCF ababhedlele kwi- P. aeruginosa baya kufa ngenxa yesifo.
Ngenhlanhla, kukho ezininzi izidakamizwa namhlanje ezinokunyanga nokukhusela i- P. aeruginosa isifo. Ezi ziquka i-antibiotics tobramycin, i-levofloxacin, i-ciprofloxacin, i-azithromycin kunye ne-spectrum cephalosporins. Ukukhethwa kwezidakamizwa kudla ngokusekelwe kwiimvavanyo ukufumanisa ukukhawuleza kwenkxalabo ye-Pseudomonas kwiinqunto ezahlukeneyo ze-antibiotics.
Ulawulo luyehluka ngohlobo kunye nesigaba sentsholongwane. I-tobramycin okanye i-levofloxacin ifakwe rhoqo ngeenyanga ngexesha lokukhusela ukukhula kwebhakteria. I-ciprofloxacin yomlomo kunye ne-azithromycin ingasetyenziselwa ukuthintela ukusuleleka okanye ukuphatha isifo sosuleleko.
I-P. aeruginosa inokuphathwa kwakhona ngefomicillin ebizwa ngokuba yi-ureidopenicillin.
Olunye Uphuhliso Lwonyango lweCystic Fibrosis
Ukongezelela kwindlela yokwelapha i-antibiotic esebenzayo, ezinye iintuthuko zenzelwe unyango lweengxaki zombini kunye ne-CF. Ziquka:
- ukuxhaswa kwe-enzyme ye-pancreatic ukunqoba iingxaki zokugonya ngenxa ye-buildup ye-mucus kwindlela yokugaya
- I-Pulmozyme (dornase alfa) ephazamisa i-muscus ekhusela iindlela zokuhamba
- i-bronchodilators (i-inhalants egcina ii-passages)
- ukuphucula imishanguzo echasayo
- inhaled hypertonic saline ukwenzela ukwandisa inani le-sodium elahlekileyo kwi-airways
Zonke ezi zinto zigalelo ekunyuseni izinga lokusinda kubantu abakwiCF.
ILizwi
I-Cystic fibrosis isifo esihluke kakhulu kunokuba bekuyi-20 okanye engama-30 edlulileyo. Namhlanje, abantu abaneCF banokuphila ubomi obuqinileyo nofezekileyo, ukuya kwikholeji, ukufumana imisebenzi, kunye nokucwangcisa intsapho. Yonke into ithatha iminyathelo engama-6 ukuqinisekisa ubomi obude kunye nobomi:
- ukuqonda unyango lwakho kwaye uthabathe njengoko uqondiswe
- ukuqinisekisa ukutya okunempilo, okunokulinganisela kunye nama-calories ama-50 ekhulwini
- ukusela amanzi amaninzi ukuhlala kakuhle
- ukudala iplani yokufaneleka equkethe ukuxhatshazwa kunye nokuqeqeshwa kwe-cardio
- ukuphepha ukusuleleka ngokuthe rhoqo ukuhlamba izandla, ukufumana iintsholongwane, nokuphepha abanye abagulayo
- Ukubona ugqirha wakho rhoqo ukuqinisekisa ukuqhubekeka kokunyamekela
Ekugqibeleni, i-cystic fibrosis ayikho isigwebo sokufa esasetyenziswa kuso, kwaye, ngokunyamekela nokunyangwa okufanelekileyo, akukho sizathu sokuba ungeke udlule ukulindela kumgangatho nobuninzi bobomi.
> Umthombo:
> O'Sullivan, B. kunye noFransman, S. "I-Cystic fibrosis." Lancet . 2009; 373 (9678): 1891-1904.