Ingaba I-Asmafi iphakamisa Ingozi yeChre Cancer?

by Lynne Eldridge, MD; Ukuphononongwa nguGrant Hughes, MD

Ngaba abantu abane-asthma mhlawumbi banokufumana i-Cancer Lung Cancer?

Ingaba I-Asmafi iphakamisa Ingozi yeChre Cancer?

I-asthma inokuphakamisa umngcipheko womhlaza wamaphaphu nangona sifunda nje ukubona ikhonkco kunye nokuba ingaqhelekanga njani. Ukunikezelwa kwenani labantu abaphethwe yi- asthma , kunye nolwazi lokuba umhlaza wesifo somdlavuza yimbangela ebangela ukuba ukufa komhlaza kubesilisa nabesifazane base-US, lo ngumbuzo obalulekileyo.

Ngokubanzi, kubonakala ukuba ulungelelwano luqine kakhulu kunabanye ababhemayo . Yintoni esiyifundile kude kube ngoku?

Izifundo ezidibanisa i-asthma kumdlavuza wamaphaphu

Ngokubhekisele kumdlavuza omncinci wamangqamuzana omnxeba , izifundo zaseTshayina zibonisa ukuba unxibelelwano phakathi kwe-asthma nomdlavuza wemiphunga kubalulekile. Ingozi eyongeziweyo iyahlukahluka kwezo zifundo, kunye nabantu abane-asthma abanamaxesha angama-2 ukuya kuma-6 amathuba okuba nomdlavuza wamaphaphu kunabo abangenayo i-asthma. Kubalulekile ukuba ukhumbule ukuba umhlaza wesifo somhlaza wamangqamu unomdla ongaphantsi koomdlavuza wamaphaphu, ukubalwa kwamanye ama-15 ekhulwini.

Izifundo ezijongene nomngcipheko womdlavuza wamaphaphu kunye nesifo se-asthma kubonakala kubonisa ukuba umngcipheko mkhulu kubantu abangabhemi kunokuba batsha.

Uphononongo olukhulu olujonge uphando oluninzi lufumene ukuba, ngokuqhelekileyo, umdlavuza wamaphaphu wawunokuphindwa kwezihlandlo eziyi-1.8 eziqhelekileyo kubantu abangabhemi bomoya abane-asthma abangenabo abatshitshisiyo abangenayo i-asthma. Xa izifundo zikhangele abantu jikelele e-US-kubandakanywa nabantu ababhema-ingozi yokuba abantu abane-asthma babengama-1.4 amaxesha okuba banomdlavuza wemiphunga.

Uphononongo olutshanje lufumene ukuba i-asthma idibene nomngcipheko okwandisiweyo kuwo onke amanqamzana omdlavuza womphunga kuquka umdlavuza omncinci wamangqamuzana wesifo samaphaphu njengoko kuphawulwe ngaphambili, kunye neengqamzana ezingekho emancinci zamaphaphu emaphaphu kuquka ne-lung adenocarcinoma, i-squamous cell carcinoma yamaphaphu, kunye umhlaza wamaphaphu wamaseli.

Kutheni i-asthma ingandisa umngcipheko womhlaza wamaphaphu?

Enye ingcinga kukuba nayiphi na into ebangela ukuphuhliswa kwesifo se-asthma ingabangela umdlavuza wamaphaphu.

Siyazi ukuba ukutshaya okanye ukutshatyalaliswa komsi womsi wesinokuba ngumngcipheko we-asthma kunye nomdlavuza wamaphaphu. Nangona kunjalo ezininzi zezifundo zijonge ukudibanisa phakathi kwe-asthma nomdlavuza wamaphaphu "ukulawula" ukutshaya. Okokuthi, bafumana indlela yokuphelisa ukutshaya njengekhonkco ukwenzela ukuba bajonge kwezinye iimeko (ezibizwa ngokuba zifundo ezilawulwayo.) Xa oko kwenziwa, umngcipheko womhlaza wemiphunga ohambelana nesifo se-asthma usahleli.

Enye ingcamango kukuba ukuvuvuka kwexesha elide emiphakeni ngenxa yesifo se-asthma kungabangela isizathu. Ukuvutha kwexesha elide kuye kwavavanywa kungekudala nje ngenxa yezizathu ezininzi zamanomdlavuza. Ucwaningo oluninzi lubonisa ukuba ukutshaya okungapheliyo kwimiphunga ngenxa yesifo se-asthma kusenokuthi "umququzeleli" ekwenzeni umdlavuza wamaphaphu-oko kuthetha ukuba isifo se-asthma, kunye nezinye izizathu, sinokusebenzisana ukufaka ingozi kumdlavuza wamaphaphu.

Kodwa ijaji iphume. Kwisifundo esinye, ukunika iigundane zamakhemikhali ukudala umdlavuza wamaphaphu akuzange kubangele naziphi na izicubu kwiimiceba ezine-asthma. (Enyanisweni, ukuba ne-asthma ayibonakali ibangela ukuba i-OR ithinte ukuqhubela phambili kwamagundane asele nomdlavuza wamaphaphu.) Ngokufanayo, uphando lwaseCanada lufumene ukuba abantu abane-asthma babenomngcipheko omncinci wokuphuhlisa iintlobo ezi-8 zomhlaza. Kwaye kwavezwa kwizo zifundo ukuba "isistim somzimba", njengoko sibonwe nge-asthma, sinokukunceda ekupheliseni amaseli angaba ngumhlaza.

Kanti enye ingcamango kukuba kukho inkqubo engaphantsi kwenkqubo yokongeza ukunyuka okubangako kwandisa ingozi. Siyazi ukuba ukuba neCOPD yingozi yecala lomhlaza wamaphaphu. Ngamanye amazwi, abantu abaneCOPD banakho amathuba okuba nomdlavuza wamaphaphu kunokuba baqikelelwe ngokusekelwe kwimbali yabo yokutshaya yodwa.

Yintoni endiyenzayo ukuba ndiyenayo i-asthma?

Yintoni ongayenza ukuba une-asthma? Ngokuqinisekileyo, ukuba ubhema, kubalulekile ukuyeka. Ukuphepha ukutshaya umsi kubalulekile. Kodwa ngenxa yokungabhemi, kunengqiqo (nangona singenayo iiphononongo ezibonisa ukuba yenza umehluko) ukuqinisekisa ukuba i-asthma ilawulwa kakuhle ngokusemandleni.

Emva koko, nangona oko kungenzi umda kumngcipheko womdlavuza wamaphaphu, ukuhlala ne-asthma ephantsi kolawulo kuyindlela evuyayo yokuphila.

Isifo somdlavuza sisifo esibhubhisayo kwaye ngoku siyiyona nto ibangela umdla wokufa komhlaza kumadoda nabasetyhini e-United States. Umdlavuza womlenze ongabikho abokutshayila ngowesi-6 ekhokelela ekubangeni ukufa komhlaza. Hlola ezi ngcebiso malunga nokukhusela umdlavuza wamaphaphu - ezinye usenokuba wazi kakuhle, kunye nezinye ezinokumangalisa. Yaye khumbula: nabani abaneemiphunga bangakwazi ukufumana umdlavuza wamaphaphu.

_Imithombo:

_{Brown, D. et al.} _{I-asthma kunye nomngcipheko wokufa komdlavuza wamaphaphu: I-NHANES II YokuFundelwa Kwokufa.} _{Umbhalo we-Asthma .} _{2005. 42 (7): 597-600.}

_{UDoris, uK. et al.} _{Ukuvutha komzimba akuchaphazeli i-carcinogenesis eyenziwa ngamakhemikhali kwimiphunga yamagundane.} _{Uphando loPhepha .} _{2010. 11: 118.}

_{El-Zein, M. et al.} _{Imbali yesifo se-asthma okanye i-eczema kunye nomngcipheko womhlaza phakathi kwabantu: isifundo sokulawulwa kwamacala e-population e-Montreal, Quebec, Canada.} _{Ama-Annal of Allergy, i-Asthma & Immunology .} _{2010. 104 (5): 378-84.}

_{Fan, Y. et al.} _{Isifo sesandulela sesifo sengqondo kunye nomngcipheko womdlavuza wamaphaphu kwiqela elixhomekeke emsebenzini eliseYunnan, eChina.} _{Cancer Lung .} _{2011. 72 (2): 258-63.}

_{Huang, J., Jian, Z., Nfor, O. et al.} _{Imiphumo yezifo zamapulmoni kwiintlobo zeengcambu zeengqumbo zomdlavuza kumabini ngesini: isifundo esisekelwe ngabantu esiseTaiwan.} _{BMC Cancer .} _{2015. 15: 834.}

_{Liang, H. et al.} _{Umngcipheko womhlaza wamaphaphu ulandela izimo ezingapheliyo zokuphefumula phakathi kwabasetyhini abangaboniyo abahlala eShenyang, eNyakatho yeChina.} _{Journal of Women's Health .} _{2009. 18 (12): 1989-95>}

_{Lim, W. et al.} _{Iipolymorphisms kwindlela yokuguqulwa kwamagciwane, iziganeko zokusingatha kunye nomngcipheko womdlavuza wamaphaphu kwintombi yaseTshayina abangabhemi.} _{ICarcinogenesis .} _{2011. 32 (4): 522-9.}

_{Pirie, K., Peto R., Green, J. et al.} _{Umdlavuza womlenze ongabikho ababhemayo.} _{Journal International of Cancer .} _{2016 uMar 8. (uEpub ngaphambi kokuprinta).}

_{Santillan, A. et al.} _{Uhlalutyo lwe-meta-asthma nomngcipheko womhlaza wemiphunga (eMerika).} _{Iingxaki zeCans & Control .} _{2003. 14 (4): 327-34.}

_{Sanz, G. et al.} _{I-asthma nomngcipheko womhlaza wemiphunga.} _{I-Clinical and Translational Oncology .} _{2011. 13 (10): 728-30.}