I-Zollinger-Ellison Syndrome (i-ZES) yintlupheko engavumelekanga eyenza enye okanye amaninzi amathumbu ukuba enze kwifakreta okanye inxalenye ephezulu yamathumbu amancinci okuthiwa i-duodenum. Ingabangela ukuba izilonda ziphuhlise esiswini nase-duodenum.
Iimvama zibizwa ngokuba yi-gastrinomas, kwaye ziyakubhalisa inani elikhulu le-hormone gastrin. Oku kubangele ukuveliswa kwe-acid esiswini, okungakhokelela kwizilonda zamapulp .
I-Zollinger-Ellison syndrome ayinqabile, kwaye nangona inokwenzeka nakweyiphi na ubudala, abantu abaphakathi kweminyaka engama-30 no-60 banako ukuphuhlisa. Kwakhona, kubo bonke abantu abanesifo sesilonda, kuphela ipesenteji encinci kulabo bantu baya kuba neZollinger-Ellison.
Iimvumi zinesifo somhlaza kuma-50 ekhulwini lamatyala. Besebenzisa i-hormone ebizwa ngokuba yi-gastrin eyenza isisu siphumelele i-asidi eninzi, leyo ibangela ukuba isisu nesilonda sezilonda (izilonda ze-peptic ulcers). Izilonda ezibangelwa i-ZES azixhomekanga kunonyango kunezilonda eziqhelekileyo. Yintoni ebangela ukuba abantu abaneZES bahlakulele izicubu ezingaziwa, kodwa malunga neepesenti ezingama-25 zeemeko ze-ZES zidibene ne-genetic disorder ebizwa ngokuba yi-neoplasia ye-endocrine.
Iimpawu
- Gnawing, intlungu evuthayo esiswini
- Le ntlungu ivame ukufumaneka kwindawo ephakathi kwebhondi kunye nenkaba.
- Uvakalelo lwexinzelelo, ukucima, okanye ukuzaliseka
- Le ntlungu ivame ukuvelisa imizuzu engama-30 ukuya kweyesi-90 emva kokutya kwaye idla ngokukhululeka ngama-antacids.
- Ubuhlungu okanye ukuvutha kwesisu kwisisu esisenyukayo ukuya emqaleni
- Oku kubangelwa ukuguquka kwentliziyo , okanye i- reflux ye-gastroesophageal , kwaye kwenzeka xa isisu siphakanyiswa kwisipopu.
- Ukuvutha
- Umhlanza unokuba negazi okanye ufana neendawo zekhofi.
- Uhudo
- Izitshixo zingashenxiswa.
- Amnyama, iitars
- Igazi kwiisitopu liya kubabomvu ebomvu okanye kumnyama, kwaye benze ukuba bahlale bahlale okanye baxakeke.
- I sizathu
- Ukukhathala
- Ubuthathaka
- Ukuhla ukusinda
Izizathu
Isifo se-Zollinger-Ellison kubangelwa i-tumor (gastrinoma) okanye i-tumors kwi-pancreas kunye ne-bowel encinci (duodenum). Ezi zicubu zivelisa i-hormone gastrin kwaye zibizwa ngokuba yi-gastrinomas. Amanqanaba aphezulu e-gastrin abangela ukukhutshwa kwe-acid esiswini. Ukwanda kwe-acidity kunokukhokelela ekuphuhlisweni kwezilonda zezilonda zesisu esiswini nase-duodenum.
Ukuxilongwa
Uvavanyo lweGazi
Uvavanyo lwegazi luyenziwa ukuze lubone ukuba kukho i-gastrin eyongeziweyo kwigazi. Inqanaba eliphakamileyo le-gastrin lingabonisa iimvumi kwi-pancreas okanye kwi-duodenum.
I-Barium X-ray
Isigulisi siphuza umbane oqulethe i-barium, eya kuguqa iindonga zesisu, isisu, kunye ne-duodenum. I-ray-ray iyathathwa. Ugqirha uya kukhangela i-X-ray, efuna iimpawu zezilonda.
Endoscopy ephezulu
Ugqirha uhlola ngaphakathi kwisisu, isisu, kunye ne-duodenum ngesixhobo esibizwa ngokuthi i-endoscope, ityhubhu ephothiweyo enefuthe elikhanyayo ene-lens. I-endoscope ifakwe emlonyeni nasezantsi emqaleni, kunye nasesisu nase-duodenum. Ugqirha unokukhangela izilonda, kwaye unokususa isampuli yesikhumba, ebizwa ngokuba yi-biopsy, ukulungiselela uviwo kwibhubhoratri ukuchonga ukuba kukho ubukho be-tumor gastrin-producing.
Iindlela zokuCinga
Ugqirha unokusebenzisa i-computer ye-tomography (CT) yokukhangela, ukukhangela i-imagination magnetic imaging (MRI), kunye ne-ultrasound, okanye ukuskena kwesikrukliya ngenzame yokufumanisa apho iifom zikhona khona.
- I- CT scan iyilinga lokuxilonga olusebenzisa ii-X-ray ngokuxhaswa ngeteknoloji yekhompyutha. Iimitha ze-X-ray zithathwa kwiindidi ezininzi ezahlukileyo ukudala imifanekiso eqingqiweyo yomzimba wesigulane. Emva koko ikhomputha ihlanganisa le mifanekiso ibe mfanekiso wesithathu ongabonakalisa izitho, amathambo kunye nezicubu ngokubanzi.
Nge- scan ye-MRI , izibonakaliso zamagnetic zisetyenzisiweyo kunokuba zi-X-ray ukudala imifanekiso yomzimba womntu. Ezi mifanekiso zibonisa ukungafani phakathi kweentlobo zeetunsu.
I- ultrasound ithumela amaza omsindo ophezulu oya kwiindawo ezihlolwe kwaye aphinda ahlawule xa ahlasela ilungu. Oku kuqhutywa yikhompyutha, evelisa imephu yendawo echithwa.
Nge- scan scan , i-radioactive substances zifakwa emzimbeni ovumela ikhamera ye-gamma ukufumana izicubu.
Iingxaki zeZollinger-Ellison Syndrome
Kwimizuzu engama-50 yamatyala e-Zollinger-Ellison, iimvumi zinomdlavuza (ezibi kakhulu). Ukuba iimvumi zinesifo somhlaza, kunomngcipheko wokuba umdlavuza usasazeka kwisibindi, i-lymph nodes kufuphi neepascreas kunye nentlungu encinane.
Ezinye iziganeko zeZollinger-Ellison Syndrome
- Izilonda ezinamandla ezinokukhokelela ekuphuhliseni umgodi kwisilonda
- Ukulahleka kwegazi
- Isifo sohudo
- Ukuhla ukusinda
Unyango
Ukunyangwa kwe-Zollinger-Ellison syndrome kugxininisa kwimimandla emibini: Ukunyanga izidumbu kunye nokunyanga izilonda.
Unyango lweeNtsholongwane kwiZollinger-Ellison Syndrome
Uphando luvame ukuqhutyelwa ukuba kukho isifo esisodwa kuphela. Ukuba izibilini zisesibindi, ugqirha uya kususa ubuninzi besifo sebindi kunokwenzeka (ukuhlawula).
Xa utyando lwe-tumors alukwazi, ezinye zonyango zisetyenziswa:
- Ukuzama ukutshabalalisa i-tumor ngokunqumla ukunikezelwa kwegazi (ukuhlanganiswa).
- Ukuzama ukutshabalalisa iiseli zomhlaza ngokusebenzisa i-current current (i-radio-frequency ablation).
- Ukusetyenziswa kweziyobisi kwi-tumor ukukhupha iimpawu zomhlaza.
- Ukusebenzisa i-chemotherapy ukuzama ukucotha ukukhula kwengcinezelo.
Unyango lwe-Ulcers kwi-Zollinger-Ellison Syndrome
Proton Pump Inhibitors
Le yile miyeza enempumelelo kakhulu ye-Zollinger-Ellison syndrome. Iproton pump inhibitors inamandla kwaye igxotha ukuveliswa kwe-acid kwaye ikhuthaza ukuphulukiswa. Imizekelo yeproton pump inhibitors iquka iProlosec , Prevacid , Nexium , Aciphex , nePro protonix .
I-Acid Blockers
Ezi zibizwa ngokuba yi-histamine (H-2). La mayeza anciphisa inani le- hydrochloric acid ekhutshwe kwi-digestive tract. Oku kunceda ukukhulula intlungu yesilonda nokukhuthaza ukuphulukiswa. I-Acid blockers isebenza ngokugcina i-histamine ukufikelela kwi-histamine receptors. Iimbali ze-historic receptors zibonakalisa izisele ze-asidi zokufihla esiswini ukuze zikhulule i-hydrochloric acid. Imizekelo ye-acid blockers iquka iTagamet , iPepcid , iZantac , neAxid .
I-Acid blockers ayisebenzi kunye ne-proton pump inhibitors, kwaye ayinakumiselwa ngugqirha. Kwabo bantu abasebenzisa i-acid blockers, bafuna amayeza aphezulu, aqhelekileyo ukuba asebenze.
Prognosis
Njengoko kuchaziwe ngasentla, kuma-50 ekhulwini amatyala e-Zollinger-Ellison, iimvumi zixhatshaza. Ukuxilongwa kwangaphambili kunye nokuveliswa kwendlela yokugonywa kungafezekisa izinga lokunyanga elimalunga no-20% ukuya kwi-25%. Nangona kunjalo, ulwazi lwezokwelapha lubonisa ukuba i-gastrinomas ikhula ngokukhawuleza, kwaye izigulane zihlala iminyaka emininzi emva kokuba i-tumor ifunyenwe. Amachiza okucima i-Acid asebenza kakuhle ekulawuleni iimpawu ze-acid ezingaphezulu.
Yonke ingcaciso kweli nqaku iye yenzelwe iinjongo zemfundo kuphela. Ukuxilongwa, kufuneka ubone umboneleli wakho wezempilo. Ngelo xesha yonke imiba yalo mqathango, kunye neendlela zokonyango kunye nokunyamekela nokunyamekela kwimeko, kufuneka zixoxwe nodokotela wakho. Emva kokuxilongwa, ukuba ufanele ufumane kunye neempawu ezintsha okanye ezibuhlungu, ezi zinto kufuneka zixelelwe ugqirha wakho.