Abaphandi Bafuna "Ukukhahlela" i-HIV kwiindawo zayo zokufihla
Izilwanyana zamandulo ziiseli zomzimba apho i-HIV iyakwazi ukufihla (okanye "ukuqhubeka") nangona uphethwe unyango oluchanekileyo lwe-antiretroviral . Ezi zixhobo zamagesi zikhona kwiinkqubo ezininzi zeesigqeba, kuquka ubuchopho, izicubu ze-lymphoid, umongo we-bone kunye nesondo lomzimba.
I-state yangasemva (okanye i- proviral ), i-HIV inokudibanisa izinto zayo zofuzo kwi-DNA yeselula, kodwa kunokuba ibulale, imane iphinde iphendule kunye nomphathi.
Ngokungafani nentsholongwane ye-virus-free circulation, ezi profiysi ezifihliweyo azikwazi ukufunyanwa ngumzimba womzimba. Kunoko i-genome yentsholongwane iqhutshwa kwisizukulwana kwisizukulwana, iyakwazi ukuvuselela xa ibangelwa ukuwa kwi-immune function.
Enyanisweni, impendulo yomzimba yomzimba eyenza i-HIV iindawo zayo zeevili. Xa iimpendulo zokuzivikela kumzimba ziqhutyelwa phambi kwe-HIV, umzimba uya kuvelisa i- CD4 T-cell , ezithandabuzayo, ezijoliswe ekujoliswe kukosulelo. Amaseli asele anentsholongwane kaGawulayo aya kwanda, avelise ii-cells ezitheleleke nge-HIV kunye nokwandisa i-viral reservoir.
Kuyinto yokuphikelela kwezi zigulo ezifihlakeleyo eziqhubekayo ukuphazamisa imizamo yokuphucula isifo sesi sifo.
Amacandelo okuSula iiNdawo zokuLondoloza eziPheleleyo
Umngeni onzima kakhulu ojongene nabaphandi namhlanje ufumana iindlela zokuqalisa kunye nokucoca i-HIV kwiindawo zayo zokuhlala, ukushiya kubonakala kuyo nayiphi na inamba yezicwangciso zokuphelisa .
Nangona i-ART iyakwazi ukukhupha le mijelo phezu kwexesha, yenza ngokukhawuleza. Imodeli yeMathematika ibonise ukuba kuya kuthatha iminyaka engama-60 ukuya kuma-80 ukupheliswa ngokupheleleyo.
Ukwandisa, abaphandi bajonga ukusetyenziswa kwezidakamizwa ezithile ezibonakala ngathi zikhuthaza ukusetyenziswa kwe-HIV ekhoyo.
Phakathi kwabo kukhona ii-agents ezibizwa ngokuba yi-HDAC inhibitors, ezisetyenziswe ixesha elide njengezinto ezizinzileyo kunye ne-anti-epileptics.
Kwaye nangona kubekho impumelelo ekusebenziseni i-HIV engavumelekanga, izazinzulu azikwazi nokuba zikhulu kangakanani ezi zikhuni okanye ezinye iiseli zinokunika i-HIV indawo yokufihla. Ngoko ke, akunakwenzeka ukwazi ukuba ezi zikhuni ziye zacinywa ngokwenene ngala majelo enkampu.
Uphando olutshanje, eqinisweni, lubonise ukuba ngelixa ezinye izidakamizwa ze-HDAC ze-inhibitor zinamandla okusebenzisa i-HIV engavumelekanga, akukho ubungqina bobubungqina bokuthi ukusebenziswa okunjalo kuye kwanciphisa ubukhulu bamagumbi.
Ezinye izazinzululwazi, okwangoku, zibuza ukuba "ukukhaba" i-HIV kumagumbi ayo kuya kukwanela ukufezekiswa. Ngenxa yoko, iqela lala maqela ophando lihlola ii-agents ezibonakalayo zikwazi ukubulala intsholongwane entsha esandululweyo nge-toxicity encinci. Phakathi kwabaviwa abathembisayo kakhulu i-acitretin, ifomu ye-vitamin A ngoku kusetyenziswa ukunyanga i-psoriasis enzima kubantu abadala.
Iziphumo zengxubusho yamaLatter
Enye yeziganeko eziphazamisayo zentsholongwane yentsholongwane yukuthi, nokuba kwimeko yayo ye-proviral, ukuba khona kwe-HIV ngaphakathi kweeseli kubangela impendulo eqhubekayo yokuvuvukala. Nangona umntu ephethe unyango olufanelekileyo lwe-HIV kwaye unako ukugcina umthwalo wentsholongwane engabonakaliyo , ukuvuvukala okungapheliyo kwinqanaba elingaphantsi kungaqhubela phambili ngendlela eyenza iiseli kunye nezicubu ziphendule, ngokukhawuleza ukukhawuleza ukuguga.
Inkqubo, ebizwa ngokuba yi- senescence yangaphambili , isizathu sokuba abantu abanokusuleleka kwintsholongwane kaGawulayo kwixesha elide banomngcipheko ophezulu weengcingo, isifo senhliziyo, ubuthathaka besithambo, kunye neengxaki ze-neurocognitive-kwaye ngokuphindaphindiweyo kwiminyaka eyi-10 ukuya kwe-15 ngaphambili ngaphambili kunokubaluleka kuluntu jikelele labantu.
Imithombo:
Douek, D. " UkuViliswa kwe-immune , ukunyamezela kwe-HIV, kunye neCure." Izihloko kwiMithi yamayeza. Matshi 2013; fi kelele ngoNovemba 19, 2015.
Sáez-Cirión, A .; Bacchus, C; Hocqueloux, L .; okqhubekayo. I-Post-Treatment HIV-1 Abalawuli abane-Remote Virological Remission emva kokuphazamiseka kweNyango yokuqala ye-Antiretroviral I-ANRS VISCONTI. I-PLoS Pathology. Matshi 14, 2013; 0 (3): e1003211.
Søgaard, O .; Graverson, M .; Leth, S; okqhubekayo. "I- HDAC inhibitor romidepsin ikhuselekile kwaye ibuyisa ngokuphumelelayo i-HIV-1 latency e-vivo njengoko ilinganiswe ngama-test e-clinical standard." INgqungquthela ye-AIDS ye-20; Julayi 22, 2014; EMelbourne, eOstreliya; TUAA0106LB.
U-Eisele, E. no-Siciliano, R. "Ukuhlengahlengisa iindawo zokukhusela i-HIV-1." Ku khuselwa. NgoSeptemba 21, 2012; 37 (3): 377-388.
Peilin, L; Kaiser, P .; Lampris, H .; okqhubekayo. "I-Stimulaiting indlela ye-RIG-1 yokubulala amaseli kwiindawo zokugcina ezisemva kwe-viral activation." Nature Medicine. NgoJuni 13, 2016; 22: 807-8-11.