Iimbutho eziPhambili ziPhakamise indlela eya kuKhutshwa kwexesha elide
Uphulo olusebenzayo luyi-hypothetical-based hypothesis apho i-HIV ingagcinwa ingqwalasela ngaphandle kokusetyenziswa kwamayeza angapheliyo. Ngokuchasene nesitofu sokugonya , apho i-HIV iya kupheliswa ngokupheleleyo emzimbeni, unyango olusebenzayo lusebenza ngakumbi kumigca yokuxolelwa apho intsholongwane ayikwazi ukubangela ukugula nangona iintsholongwane zihlala zihlala.
Kuye kwaba nomdla omkhulu kwaye phantse ingxabano ejikeleze ithemba lokuphulukiswa komsebenzi. UFrançoise Barré-Sinoussi , u-Co -find out of HIV, wathi ngo-2013 ukuba ukholelwa ngokupheleleyo ukuba unyango olunjalo lunokuthi lufumaneke "kwisithuba seminyaka engama-30 ezayo." Ngokwahlukileyo, uRobert Gallo (naye ubizwa ngokuba yi-HIV) uyayicinga loo nto iphosakeleyo kwaye ikholelwa ukuba iindawo zeengcamango "azikwazi ukusebenza."
Indlela Uphilo olusebenzayo olunokusebenza
Enye yeyona mingeni ebhekene nobunzima abajongene nabaphandi sele ibe ngamaseli kunye nezicubu zomzimba (ezibizwa ngokuba yimithombo yamanzi e-latent ) apho i-HIV ingakwazi ukuqhubeka nokujongana nokunyanzeliswa kwe-HIV. Efihliweyo kule mijelo yamaselula yikhowudi yofuzo lwe-HIV, apho i-immune system ayikwazi ukuyijonga.
Ukususela ekubeni intsholongwane ayifani ngokuphindaphindiweyo-kodwa kunokuba iqhutywe ngokunyanzeliswa njengoko isalathisi sesigidimi sichaza-ingakumbi i- antiretroviral (ukususela kwimisebenzi ye-antiretrovirals ngenxa yokuphazamisa isigaba kwinqanaba lobomi be-virus), kungekhona impi.
Kukho imizekelo embalwa ehlolisiswayo ukujongana nale:
- Ukucima iindawo zokugcina. Ezinye izazinzulu ziye zabonisa ukuba, ngokuvuselela iinqaba, i-HIV ingasetyenziswa kwakhona kwaye ikhutshwe kwiindawo ezingcwele ezifihliweyo. Ukwenza oko kuvumela i-ART kunye namanye ama-agent athoxayo ukuba aphelise ngokupheleleyo intsholongwane entsha, icebo elibizwa ngokuthi "ukukhaba." Amachiza amaninzi anokukwazi ukucima ezi zixhobo zokubaluleka kodwa ukuza kube yimini, kuphela. Ukuhlanganiswa kweziyobisi ezintsha kulindeleke ukuba kuphuculwe kwezi ziphumo.
- Khuthaza umzimba ukuba uvelise ama-antibodies "abulala". Kukho iintlobo zama-proteins omzimba, ezibizwa ngokuba ngama-antibodies, eziveliswa ngumzimba ngokuphendula isifo. Ezinye zazo zikwazi ukuphelisa i-HIV. Ingxaki kukuba i-HIV iyatshintsha ngokukhawuleza kangangokuthi akukho nto ininzi ngokwaneleyo ye-antibodies yokubulala i-anti-stroke. Kwiminyaka yakutshanje, nangona kunjalo, ososayensi baye bafumanisa ukuba abantu abathile, abaqhathaniswayo bazibandakanya ngokubanzi ukukhupha i-antibodies (BnAbs) ekwazi ukubulala ubuninzi beentsholongwane ze-HIV. Iingcali zenzululwazi zihlola iindlela zokuvuselela ezo zithunywa zendalo, isicwangciso esinokukunceda ukuzalisekisa isithembiso "sokukhaba
Ubungqina kwiNkxaso yeCandelo lokuPhilisa
Nangona uphando olwenziwe kunyango luye lwasetafileni iminyaka emithathu, iziganeko ezithile zanikezela ubungqina bombono-siseko.
Oyintloko phakathi kwabo isigulane esicatshulwa ukuba "siyaphiliswa" se-HIV ngo-2009. UTimoti Brown (umonde waseBerlin) wayephila nge-HIV e-Berlin e-Berlin eyanikezwa umthambo we-bone umtsalane ukuze uphathe i-leukemia yakhe. Oogqirha bakhetha i-stem donor amabili kunye neikopi ezimbini zokuguquka kwemfuzo ebizwa ngokuba yi-CCR5-delta-32, eyaziwa ukulwa negciwane lesandulela ngculazi kubantu abangabonakaliyo .
Uvavanyo oluqhelekileyo olwenziwa emva nje kokuba ukufakelwa kwembonakalo kubonakalise ukuba i-antibodies ye-HIV egazini likaBrown uye wehla ukuya kumanqanaba afana nokucebisa ukuphelisa ngokupheleleyo intsholongwane. Iziganeko ezilandelayo ziqinisekisile ubungqina beNTSHOLONGWANE KAGAWULAYO kunoma yiyiphi i-brown tissue, exhasa iingxelo ukuba le ndoda yayiphilisiwe. Ngoxa iingozi zokufa zibhekwa phezulu kakhulu ukuba zihlolisise ukuguquka komongo we-bone njengendlela yokunyanga, ubuncinane ubone ubungqina bokuthi unyango luyabonakala.
Okwangoku, ezinye izazinzulu ziye zaphanda amagosa ahlolisayo anakho ukucoca i-HIV kwiindawo zabo zokugcina.
Enye yezifundo zokuqala, ezenziwe kwiYunivesithi yaseNorth Carolina ngo-2009 yabonisa ukuba iklasi yezilwanyana ezibizwa ngokuba yi- histone deacetylase (HDAC) inhibitors zingenza kwakhona i-HIV engenayo kwiimvavanyo zamachiza ezibhekwa zikhuselekile kwaye zibekezeleleke.
Nangona uphando olulandelayo luye lwaphakamisa ukuba ukusetyenziswa kwe-adjethi eyodwa ye-HDAC kunokubonelela ngokukhawuleza, kukho ubungqina bokuba ukudibanisa unyango lwe-HDAC okanye iiklasi ezitsha zamachiza okuchasana nomhlaza (ezibizwa ngokuba yi-ingenol compounds) zinokuthi zihluthe ngokupheleleyo i-HIV engavumelekanga kwiindawo ezifihliweyo maqula.
Indlela eya phambili
Njengoko uthembisa ukuba yonke into yophando ingabonakala, iphakamisa imibuzo eninzi njengoko iphendula. Oyintloko phakathi kwabo:
- Ngaba iya kucoca i-HIV kwiindawo zayo zokuhlala ziwanele ukuqinisekisa ukuba intsholongwane ayiyikuseka kwakhona iindawo zokuhlala (okanye ezinye) iiseli?
- Kubaluleke kangakanani ukuba i-antibodies ibe yinto ebalulekileyo ekukhuselweni komsebenzi ekunikeni ukuba ukukhushulwa komntu oyedwa olwahlukileyo kulolu hlobo luyiyona ndlela?
- Sinokuqiniseka ukuba sinokuthi njani ukuba i- rebal rebound will not occur like it happened in case of Mississippi baby kunye nezinye iinzame ezingaphumeleli?
Nangona sibonakala ngathi yindlela efanelekileyo, kubalulekile ukujonga uphando ngokulindela ithemba. Njengokuba izazinzulu ziqhubeka zivula iimfihlelo ezijikeleze i-HIV, akukho nanye yale nkqubela ingacebise ukuba imithetho malunga nokuthintela nokunyangwa kwe-HIV ishintshile.
Ukuba kukho nantoni na, unikezelwa ubungqina bokuthi ukufumanisa kwangaphambili kunye nokungenelela kubalulekile ekunyangeni, imfuneko yokuba sihlale siphapheme, mhlawumbi, ibaluleke ngakumbi kunanini ngaphambili.
Imithombo:
> Hütter, G .; Nowak, D .; Mossner, M .; okqhubekayo. Ulawulo olude lwexesha elide le-HIV yi-CCR5 Delta32 / Delta32 Isihloko-Ukutshintshwa kweSeli. I-New England Journal of Medicine. NgoFebruwari 12, 2009; 360: 692-698.
> Archim, N .; U-Espeseth, A .; Margolis, D .; okqhubekayo. "Inkcazo ye-HIV elandelwayo yenziwa yi-HDAC Inhibitor Suberoylanilide Hydroxamic Acid." Uphando lwe-AID ye-Retroviruses zabantu. Fe bruwari 2009; 25 (2): 207-212.
> Sáez-Cirión, A .; Bacchus, C; Hocqueloux, L .; okqhubekayo. I-Post-Treatment HIV-1 Abalawuli abane-Remote Virological Remission emva kokuphazamiseka kweNyango yokuqala ye-Antiretroviral I-ANRS VISCONTI. I-PLoS Pathology. Matshi 14, 2013; 0 (3): e1003211.
> Jiang, G; IMendes, E .; Kaiser, P .; okqhubekayo. "Ukuvuselelwa kwakhona kweNtsholongwane yeNtsholongwane kaGawulayo nge-Ingenol-3-Angelate, PEP005, ejoliswe ku-NF-kB Ukubonakaliswa kwi-Combination ne-JQ1 Yenza i-p-TEFb kusebenze." PLoS Pathogens. Julayi 30 2015; INGXELO: 10.1371 / iphephandaba.ppat.1005066.