Isiza sele sineziphumo ezidibeneyo kwaye ngoku sithintela eYurophu
Abaphandi baye bafunda i-Diacerein ukuba babone ukuba iyeza liyakuthintela ukunyuka kwe-osteoarthritis. Izidakamizwa eziguqula izifo ziyaziwa unyango lwe- rheumatoid arthritis kunye nezinye iintlobo zesifo se-arthritis. Kodwa iziyobisi ezinokuguqula ukuqhubela phambili kwe- osteoarthritis , ukunciphisa umonakalo odibeneyo kunye nokunciphisa ithuba lokukhubazeka, ahlale engavunyelwe.
Ngelishwa, i-Diacerein ingabonakali ukuba ingozi iphezulu kunezibonelelo zayo, kwaye izifo zonyango lwe-osteoarthritis eziqhelekanga azizange zinciphise isifo ekuqhubekeni.
Ukwelashwa okuqhelekileyo Musa ukuNciphisa iSifo soKukhula
Ukunyanga kwezilwanyana ezingezizo iziyobisi ngamadolo e-knee osteoarthritis kunye ne- hip osteoarthritis , iimbini ezimbini ezichaphazelekayo yi-osteoarthritis, zibandakanya ukulahleka kwesisindo, ukuzivocavoca nokukhusela imisebenzi eyenza ubunzima obangela uxinzelelo kumalungu.
Amachiza kunye nezongezelelo zamagqirha asetyenziswayo ukunyanga i-osteoarthritis zibandakanya ukungenisa i-vitamin D eyaneleyo; analgesics ezifana neTylenol ; Ii-NSAID (izidakamizwa ezingekho komzimba ezichasayo) ezifana ne-naproxen kunye ne-ibuprofen; igalelo ezifana ne- glucosamine sulfate ; kunye nejoyijo . Ezinye iindlela zokwelapha nazo ziphakathi kweendlela ezikhethiweyo zonyango. Ngaphandle kokulahleka kwesisindo, akukho ubungqina obuqinileyo bokuthi le miqathango yonyango iyancipha okanye ikhusele i-osteoarthritis.
Izifundo zeDiacerein njenge-Osteoarthritis Disease-Modifier
Izifundo zihlolisise amandla okusebenzisa i diacerein ukunyanga i-osteoarthritis yamadolo kunye namaqhekeza. I-Diacerein yipilisi echasene nokuvuvukala esebenza ngokuhlukileyo kwi-NSAIDS efana neyo. I-Diacerein ikhusela i-interleukin-1, ngokuchasene nokuvimbela indlela ye- cyclooxygenase (COX) njenge-NSAID.
Kwizifundo, izigulane zifumene imimiselo ye-50 mg ye diacerein kabini ngosuku. Ngo-2006, i-Cochrane Co-collaboration yapapasha ukuphononongwa kwezifundo ezisixhenxe zeklinikhi ezibandakanya i-diacerein ezibandakanya izigulane ezingama-2,069. Yagqiba ukuba i diacerein inefuthe elincinci ekuphuculeni intlungu kunye nokunciphisa ukuqhubela phambili kwe-osteoarthritis xa kuthelekiswa nokunyanga okuqhelekileyo nge-NSAID okanye indawo ye-placebo. Impembelelo yecala eliqhelekileyo edibene ne diacerein yayisifo sohudo.
Ukubambisana kwaCochrane kuhlaziywe ukuhlaziywa kwazo ngokuchanekileyo ngo-2013, kwongezelela izilingo ezintathu ezitsha zabathathi-nxaxheba abayi-141. Uphando olutsha luqinisekisile ukuba amandla obungqina bokuphumelela kweziphumo ze-diacerein ayephantsi ukuya kumodareyitha, kwaye ukunciphisa intlungu kwakuncinane. Kwi-osteoarthritis ye-hip, kwakukho inzuzo encinci yokunciphisa indawo edibeneyo, kodwa mhlawumbi kwakungekho efanelekileyo. Kukho umngcipheko wama-24 we-developing diarrhea ngenxa ye-diacerein.
I-Arhente Yamayeza EYurophu Ibeka Imingcele
Ngo-Matshi 19, 2014, iqela lokuQinisekisa ukuBamkela kokuBambisana kunye neNkqubo eziMiselweyo-uLuntu (i-CMDh) evunyelwe ukunciphisa idicerein kwi-Yunited Union. Isigqibo sasibophelwa ngokusemthethweni ngo-Sept. 4, 2014. Eli qela lisekelwe kwisigqibo saloo mngcipheko wezigulana ezinokukhupha iilhurha ezinzulu kunye neengxaki zesibindi ngenxa yeziyobisi.
Ngamafutshane, iqela lagqiba ukuba iingozi ze-diacerein zazingaphezu kweenzuzo zayo.
Ngaba uphando olungakumbi malunga neDiacerein lufuneka?
I-Rheumatologist uDkt. Scott J. Zashin waxoxa nge diacerein njengendlela enokwenzeka ngayo unyango lwe-osteoarthritis. "Ngeli xesha, abukho ubungqina obucacileyo bokuthi i diacerein ivelisa iziphumo ezibalulekileyo njengesisifo sokuguqula isifo se-osteoarthritis," watsho. "Kufuneka uphando olongezelelweyo ukuseka ukhuseleko olufutshane kunye nexesha elide kunye ne-diacerein ye-osteoarthritis."
Isiza asifumaneki eUnited States, i-European Union, eCanada, eBrithani, okanye e-Australia. Inokufumaneka kwiindawo ezikhethiweyo, ngokubhekiselele kummiselo oqhubekayo.
Isigqibo sika-2014 se-European Union ukukhawulelana nesichengisi sichaza ukuba iziphumo ezichaphazelekayo zezidakamizwa zinzima kunokuba ziphi na izibonelelo ezinokwenzeka.
Imithombo:
Fidelix TS, Soares BG, iTrvisani VF. "I-Diacerein ye-osteoarthritis." Cochrane Database Syst Rev. 2006 Jan 25; (1): CD005117.
Fidelix TS, Macedo CR, Maxwell LJ, Fernandes Moça Trevisani V. "I-Diacerein ye-osteoarthritis." I-Cochrane Database Syst Rev. 2014 Feb 10; 2: CD005117. i-doi: 10.1002 / 14651858.CD005117.pub3.