Isixhobo soPhando lwe-Gene sisiza i-Pinpoint Type 2 Diabetes Gene Combinations
Intsimi yophando lwezofuzo iqhuma, njengoko iifrijini ezininzi kunye nokwahluka kwemfuza zifunyenwe kwaye zifundwe. Zininzi izakhi zegesi sele sele zichongiwe nezinye izifo kunye nezimo eziphambili, ezinjenge-cancer, isifo senhliziyo nesifo sikashukela .
Ukutshintsha kwe-gene ukuba ukulandelwa kwezifo zesigulane kunomdla okhethekileyo kwizenzululwazi. Ezi zintlobo zibizwa ngokuba yi-SNPs (i-nucleotide polymorphisms enye).
Ngeentsholongwane ezingaphezu kwama-500,000 kwi-genome yomntu, ityhutyana ukuya kwizenzululwazi njengoko izama ukululela ngabo ukuba zifumane ukuba zeziphi i-SNP ezijongene nezifo ezingapheliyo ezichaphazelayo.
Kuze kube ngoku, inkqubo yokufumana iizakhi kunye namaqoqo e-gene ezijongene nesifo sikashukela kuye kwafana nokuzama ukufumana inaliti kwindawo yokutya.
Isixhobo esitsha sesofthiwe, esikhuliswe kwiYunivesithi yaseMichigan Technologies, sinokufumana iigulo kunye namaqoqo e-gene anempembelelo emangalisayo kwizifo ezinzima. Ukusebenzisa isixhobo kuye kwabangela ukuba izazinzulu zenze iinguqu ezili-11, okanye i-SNP, ezidibene nesifo sikashukela se-type 2 .
Isofthiwe yenza ukuba izazinzulu zijolise kwizinto ezahlukeneyo zeentsholongwane. Iyakwazi ukunciphisa ukhetho oluvela kumawaka ezigesi ezenza i-genome yomntu phantsi kwelinye iqela elilawulwayo kwiijethi kunye nokuhluka kofuzo okunokwenzeka ukuba kudibene nezifo. Uvavanyo luya phambili ngokusebenzisa iindlela zokubala ukufumana ukuba yeyiphi indlela eyahlukileyo ngokwenzayo kunye nokuba yeyiphi inxaxheba.
UQiuying Sha, unjingalwazi oncedisayo wezibalo zeMathematika kwiYunivesithi yaseMichigan Technologies, uthi, "Ngezifo ezingapheliyo, ezinzima ezifana ne-Parkinson's, isifo sikashukela kunye ne-ALS [isifo sikaLou Gehrig], iindiza ezininzi zibandakanyeka.
Izixhobo ezikunceda ukwenza ukuchithwa kwezinto eziphilayo zilula lula kunokunceda oososayensi bafumane isizathu, kwaye ekugqibeleni unyango, luhlobo lwe-2 lweswekile.
Imithombo:
(2008, Matshi 26). INzululwazi ivela kwiProjekthi yeGenome yaBantu. Ukubuyiselwa kuMatshi 29, 2008, kwi-Web site ye-Human Genome Project Information: http://www.ornl.gov/sci/techresources/Human_Genome/project/info.shtml
I-Goodrich, M. Abaphandi Ikhonkco 11 Uhlobo lwe-Genetic Uhlobo lwe-2 lweswekile. Ukubuyiselwa ngo-Matshi 29, 2008, ukusuka eMichigan Tech News / iwebhusayithi yeMedia: http://www.admin.mtu.edu/urel/news/media_relations/673