I-Chemical Messenger kwiBongo Yakho Ebangelwa I-Narcolepsy
Inkcazo
Kuveliswe kwindawo yengqondo ebizwa ngokuba yi- hypothalamus , i-orexin yenye yezithunywa zeekhemikhali, okanye i-neurotransmitters, echaphazela i-brainstem kwaye ivuselela ukutya, ukuvuvukala nokusetyenziswa kwamandla. Oososayensi bafumene i-orexin ngo-1998, kwaye baye baphanda indima yabo ebuthongweni nasekuvukeni, kunye nokunyangwa kwezifo zokulala.
I-Orexin, ebizwa ngokuba yi-hypocretin, inxalenye yeklasi yeekhemikhali ezibizwa ngokuthi i-hormone ye-neuropeptide exitatory. Kukho ii-peptidi ezimbini ezihlukeneyo kunye nesakhiwo samachiza esifanayo, enye iyaziwa njenge-orexin-A (okanye i-hypocretin-1) enye enye i-orexin-B (okanye i-hypocretin-2). Ukulahlekelwa kwe-Orexin kunokuphazamisa amandla omzimba wokuhlala ephapheme aze alele, ubunzima obunokubangela ukuba uhlasele .
I-Orexin kunye ne-Narcolepsy
Kubantu abalala ngokulawulwa kakuhle, i-orexins ikhutshwe xa ivukile kwaye inokunceda ukwandisa umsebenzi kwi-neurons ekhuthaza ukuvuka nokukhusela ukulala kwe-REM - ubuthongo obunzulu xa uphupha amaphupha.
Xa umntu enesifo esiphambukayo, esichazwa ngokulala ngokugqithiseleyo kwemini kwaye elele ebuthongo ngaphandle kwesixwayiso, kuba i-neuron yabo-producing neurons ifile. Ngaphandle kwama-orexin, umntu onenkathazo ye-narcolepsy akakwazi ukulawula ukulala kwe-REM. Kwezinye iimeko, ukuphupha okuqhelekileyo kwenzeke ngexesha lokulala kwe-REM kunokwenzeka xa umntu ephapheme, okubangelwa kwi-hallucinations efana nephupha.
Kodwa kutheni i-orexins ifa ekuqaleni? Abaphengululi bakholelwa ukuba i-narcolepsy ibangelwa yi-auto-injection of orexin neurons. Ngokuqhelekileyo, abantu abaneengxaki ze-narcolepsy baya kunyusela amanqanaba e-antibodies anxamnye ne-streptococcus, yile ibhakteria ebangela ukuba i- strep throat . Oku kuphakamisa ukuba ukuhlaselwa ngokuzenzekelayo kubangelwa yi-strep okanye enye intsholongwane yasebusika, ingakumbi kuba i-narcolepsy ivame ukuhamba ngasekupheleni kwentwasahlobo okanye ekuqaleni kwehlobo.
Ukunyangwa kwezifo zokulala ne-Orexin
Ukuba ukungabikho kwe-orexin kubangele ukuphazamiseka kokulala, kuya kuba nengqiqo ukuba ii-orexin zinokukunceda uhlale uphapheme, kunjalo? Iklasi leziyobisi, elibizwa ngokuba yi-orexin receptor antagonists, lwakutsha nje lusetyenziswe ukuphatha iingxaki zokulala, ezifana nokulala. Ezi zixhobo zokulala zijolise kumsebenzi we-orexin, ukuvimba ukubonakaliswa kwe-orexin kwingqondo. I-Orexin inendima ekugcineni abantu bephapheme baze baqaphele, ngoko ukuvalela kwabo kukukhuthaza ukulala.
I-Orexin i-receptor agonists ihluke kwezinye izigulana kunye ne-over-counter-counter-counter-counter aid zixhobo ekujoliswe kuzo ukuba zijolise kwiinkqubo ezahlukeneyo zeekhemikhali ezahlukileyo nakwezinye indawo. I-Suvorexant, ithengiswa phantsi kwegama elithi Belsomra, ngowokuqala kweli klasi leziyobisi ukuze lifumaneke.
Hlola ezi zixhobo ukuze uthole ulwazi oluthe xaxa malunga neengxaki zokuhamba kunye nezinye izifo zokulala:
Uvavanyo lweNtsholongwane yokuLinga ukulala
Fumanisa Iimpawu Nezizathu Zobumnyama
Ubume bemiSebenzi yoBulala bokulala
Iipilisi zokulala zinganceda ngeNkqonkqo kodwa zilungele wena?
Iimpawu ezine ezichaza iinkcukacha ze-Narcolepsy
Imithombo:
Ulwahlulo lweMithi yokulala kwiSikolo sezoTyhulo saseHarvard. (Ngo-2013, ngoJanuwari 19). I-Science of Narcolepsy. Ibuyiswe ngoFebhuwari 06, 2016.
Foundation National Foundation. (nd). Ama-Orexin receptor antagonists: Iklasi elitsha lokulala ipilisi. Ibuyiswe ngoFebhuwari 06, 2016