Ukuba i-cholesterol ibe yinkinga kuwe, ugqirha wakho unokukuxelela nge-Zetia (ezetimibe) okanye i-Vytorin (ezetimibe kunye ne-simvastatin). I-Vytorin yaphuhliswa njengentlangano yeZetia neZocor (i-simvastatin), eyayihloselwe ukuphucula izakhiwo ze-cholesterol zakwa-Zocor.
Ukudibanisa? Khawukhumbule nje ukuba i-Zocor iyimifanekiso elula - uhlobo lwesilwanyana esisebenza kwisibindi ukukhusela i-cholesterol ukuba ingafaki.
I-Zetia isilwanyana esitsha, esilungele ukuvimbela ukutywala kwe-cholesterol ukusuka ekutheni ukutya emathunjini. UVittorin udibaniso lweZocor noZetia.
UVittorin waziswa kuluntu ngo-2004 ngeentengiso zeTV ezathi uVantorin unokulwa nemithombo emibili ye-cholesterol: ukutya kunye namajethi. UVittorin wajoyina iindidi ze-cholesterol ezazisesekhoyo kwiimarike, kodwa ngexabiso elincinci. Nangona kunjalo, ukuthengiswa okukhulu kweZetia, kamva uVittorin, ngokukhawuleza wabamba imimiselo ye-cholesterol yase-US yale mithi.
Izilingo zeZliniki Zineziphumo ezixubekileyo zeZetia kunye neVytorin
UZetia noVivtorin baqale bavunywa yi-FDA ngo-2002 nangama-2004, ngokulandelana, ngenxa yokukwazi ukunciphisa "i-cholesterol embi" ( LDL ). "I-cholesterol embi" ikholelwa ukuba yinto enoxanduva lokwakha i-plaque kwiindonga zobomi ezingakhokelela ekubetheni okanye kwintliziyo.
NgoJanuwari 2008 , i-Merck / Schering Plow Pharmaceuticals - umenzi weZetia no-Vytorin-wakhupha iziphumo zophando malunga nemiphumo yokudibanisa i-ezetimibe kunye ne-high-dose simvastatin ngokumelene ne-simvastatin yedwa kwenkqubo ye- atherosclerotic kwizigulane ezine-heterozygous uhlobo lwe-hypercholesterolemia , olubizwa ngokuba yi-ENHANCE.
Olu pho nonongo luqhathanise izigulane ezingama-720 ezithatha iViktorin okanye i-Zocor kuphela. Ngokusebenzisa i-ultrasounds ukuhlolisisa iiriti zeentamo ezi zivela kumabini omabini, abaphandi banethemba lokujonga ukuba i-drug combination, iVivtorin, yehlise iziganeko zokubamba i-plaque kwimibhobho yabo.
Kwakulindeleke ukuba abo bathatha iVytorin baboniswe ukuba babe neplani encinci kwiindonga zabo zokubamba kunezo zithatha uZocor yedwa.
Kunoko, izigqibo zesifundo zibonise ukuba izigulane zikaVivtorin zazingenalo i-plaque encinci kwimibhobho yabo kunezo zithatha kuphela iZocor. Enyanisweni, abo bathatha iVitotorin ngokwenene babe neplani encinane.
Iindaba ezilungileyo kwiSifundo sesiBini
Isifundo sesibini, esibizwa ngokuba nguPhuculo lokuPhuculo lweZiphumo: i-Vytorin Efficacy International Trial (UKUTHUTHUKISA-IT), iziphumo ezilinganiselwe kwizigulane ezingama-18,000 ezazikade zihlaselwa yintliziyo. Iziphumo zolu cwaningo, zichazwe ngo-2014, zifumene kakhulu izigulane kwi-Vytorin ezetimibe / i-simvastatin regimen zidibene neethagethi zazo zombini i-LDL-C kunye ne-hs-CRP kunezo zi-simvastatin kuphela. Babenemiphumo engcono yempilo ukuba badibana neentlobo ezibini, njengoko zilinganiswa ukufa kwe-cardiovascular, umcimbi omkhulu we-coronary, okanye isifo sokushaya. Umngcipheko wabo wokuhlaselwa kwintliziyo okanye ukuhlaselwa kwesibindi kwancitshiswa ngu-6%. Ulwaphulo oluhlangeneyo alubonanga miphumo embi kakhulu, ngakumbi ingozi yomhlaza.
Oku kuqhubekile ukuphikisana - ngaba kukufanele ukuthatha isicatshulwa esenza ukuba iiLbs zakho zibukeke zibhetele, kodwa unokuphuculwa okuncinci kweziphumo zempilo zakho, ukuba zikhona na?
UVivtorin wayenelumkiso kunye nezilumkiso ezongeziweyo ngo-2010 kwaye zihlaziywa ngokuthe rhoqo ukuba isilumkiso somngcipheko ophezulu we-myopathy / rhabdomyolysis. Ezi zibandakanya izilumkiso zale ntsebenziswano kunye ne-niacin kunye ne-fibrates.
Ngaba Ndifanele Ndiyeke Ukuthatha iZetia okanye iVitotorin?
Ngokukhawuleza. I-plaque ye-Arterial eceleni, izigulane zikaVittorin zenza kakuhle ngokuthe ngenye indlela, oko kukuthi, amanqanaba athatywayo "ye-cholesterol embi," leyo yinto efanayo eyawuthola imvume ye-FDA kwindawo yokuqala. Xa kuthelekiswa nezigulane zakwaZocor, izigulane zaseVittorin zahlaselwa ngokuphawulekayo kumanqanaba "amabi e-cholesterol". Ngenxa yoko izigulane zikaVittorin ekufundeni zinamaqondo amancinci "e-cholesterol amabi" angenakho ukuphuculwa kwiplagi ye-arterial ayiyiqondwanga. I-FDA iyaqhubeka iphanda lo bungqina.
Ngokuphathelele i-Zetia, iiphando zangaphambili zibonisile ukuba le nkunkuma ifuthe kumanqanaba amancinane e-cholesterol.
Ngaphandle kokuba ingahlanganiswa neZocor, ezo zigulane ezithatha i-Zetia zibonakala zinemiphumo eyavimbela ukuxutywa kwe-cholesterol ekudleni okudlula emathunjini.
I-American Heart Association iye yalinganisa ngalo mbandela ngokucebisa izigulane ezithatha iVytorin ukuba zingayishiyi unyango ngenxa yengozi yokwanda kweengozi zempilo ngokumisa ngokukhawuleza unyango lwe-cholesterol. Kwaye ukutshintshela kwesinye isiyobisi kungeke kube yimfuneko ngenxa yezizathu ezininzi:
- Ngaphandle kweziphumo ezidumazayo ekufundweni kokuqala, uVivtorin akazange abonakaliswe engakhuselekanga.
- I-statin equlethwe kwiVivinin inezinzuzo ezininzi ezibonakalisiweyo zokulwa ne-cholesterol.
- I-Vytorin okanye i-Zetia inokumiselwa ezinye izigulane ngenxa yokuba iZocor okanye enye i-statin yodwa ayinakuphumelela ekunciphiseni "i-cholesterol eyingozi."
- Amanye amayeza angenakucetyiswa kwezinye izigulane, ngenxa yezimo zonyango ezingahambelaniyo.
Kwenziwe ntoni
Njengamaxesha onke, kufuneka ukhangele ugqirha wakho. Buza ukuba kukho iimeko ezikufanele zigcine kwiikhosi langoku kunyango okanye ukuba uqale ukuhlola ezinye iindlela.
Ukuba ugqirha wakho ucebisa ukuba uhlale kwiklasi kunye neVytorin okanye i-Zetia, ngoko kufuneka:
- Qhubeka ulandela ukutshintsha kweendlela zokuphila zokutya , ukuzivocavoca kunye nokuphepha ukutshaya ukugcina i-cholesterol yakho isheke.
- Gcina ukuqeshwa kwakho kwaye uqaphele nayiphi na utshintsho kwipaneli yakho yepilid ukucacisa ukuba ngaba unyango lwakho lweyeza lusetyenziswa njengoko kulindelwe.
- Qaphela imiqondiso yakho yemihla ngemihla kwaye ubhengeze nayiphi na imiphumo engathintekiyo ongayifumana ngayo ugqirha wakho.
Nazi ezinye iziphumo ezinokuthi zijonge ngelixa zithatha iVytorin:
- intloko
- intlungu okanye intlungu
- ukusabela okuthe ngqo, kuquka ukuqhuma okanye ukuvuvukala
- iimpawu zesibindi okanye ukuvutha kwe-gallbladder, kubandakanywa ubuhlungu obukhulu besisu kunye nomchamo obomvu kunye nezihlalo
I-FDA iyaqhubeka nokuphonononga ukufunyaniswa kweengcaphephe ukuqinisekisa ukuba ngaba nayiphi na inyathelo ifanelekile. Ukuba ukholelwa ukuba uye wabandezeleka ngemiphumo emibi, okanye ukuba uye wafumana isiganeko esichaphazelayo njengesifo senhliziyo okanye isifo, xa uthabatha uVintorin okanye u-Zetia, ucelwa ukuba uyixelele kwi-FDA yeMedWatch Adverse Event Reporting program online.
Imithombo:
Abasebenzi be-American Heart Association. "Unyango Lonyango LweCholesterol." AmericanHeart.org . 4/21/2014. American Heart Association. NgoFebhuwari 11, 2016.
Abasebenzi be-American Heart Association. "Ingxelo evela kwi-American Heart Association kwi-ENHANCE yophando lweziphumo." AmericanHeart.org . 15 Januwari 2008. I-American Heart Association. 29 kuMatshi 2008
Jackevicius, uCynthia. "Ukusetyenziswa kwe-Ezetimibe eMelika naseCanada." I-New England Journal of Medicine . 28 kuMatshi 2008. I-New England Journal of Medicine. 3 kuMatshi 2008.
Abasebenzi baseSouth Food and Drug Administration, "UluNxibelelwano lwangaphambili malunga noHlolo oluPhezulu loLwazi lwe-Ezetimibe / iSimvastatin (oluthengiswa njengeVitoin), i-Ezetimibe (ithengiswa njengeZetia), kunye neSimvastatin (ithengiswa njengeZocor)." FDA.gov . 25 uJanyi 2008. Ulawulo lwe-Food and Drug US. 29 kuMatshi 2008.
Abasebenzi baseSouth Food and Drug Administration, "Ngaphakathi kwezilingo zeZliniki: IiMveliso zoLwaphulo lweZonyango kubantu." FDA.gov . 1 Septemba 2003. Ulawulo lwe-US nokuLawulwa kweeDrug. 3 kuMatshi 2008
Abasebenzi baseU.S. Ukutya kunye noLawulo lweeDrug, "iViktorin (ezetimibe / simvastatin) tablet." FDA.gov . NgoFebruwari 2014. Ulawulo lweZiko loKutya noLawulo lweeDrug NgoFebhuwari 11, 2016.
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