I-Endometriosis yimeko apho izicubu eziqhelekileyo zifake ngaphakathi ngaphakathi kwesibeleko sakho (i-endometrium) ikhula kwezinye iindawo zomzimba - ngokuqhelekileyo kwii-ovari, i-fallopian tubes kunye nezinye izitho kwiphondo ye-pelvic. Ingabangela intlungu kunye nokungafihli ngokungaqhelekanga .
I-Endometriosis yingxaki eqhelekileyo, ichaphazela malunga nama-5.5 yezigidi zamantombazana kunye nabafazi beminyaka yobudala.
Iimpawu zibonakala ziba nzima ngakumbi ngexesha okanye ixesha lakho.
Akukho nonyango ye-endometriosis. Ukuba ayiphathwa, nangona kunjalo, kunokunciphisa amathuba okuba ukhulelwe kwikamva. I-Endometriosis yenye yezona zimbangela eziphezulu ezintathu zokungabikho. Injongo yonyango ukulawula intlungu nokukhusela i-endometriosis ukuba ingabi ngakumbi. Unyango lunokubandakanywa ngamachiza kunye / okanye utyando. Uhlobo lwenyango onokulufuna ngokuqhelekileyo luxhomekeke kubunzima beempawu zakho kwaye ingaba ungafuni ukukhulelwa okanye akunjalo.
I-Depo-subQ IPprovera 104 iyinayo ye- contraceptive injection equle progestin, i-medroxyprogesterone i-acetate. Yafumana imvume yo-FDA ngo-Matshi 2005 ukwenzela unyango lweentlungu ze-endometriosis. Ukuvunywa kwe-FDA kwakusisilungiso sokuqala sezonyango se-endometriosis intuthuzelo yentlungu kwiminyaka eyi-15. Nangona le mvume ye-FDA ayisebenzisi kwiDupo Provera ipopu yasekuqaleni, i- injection yeDepo Provera inokukunceda ukuphatha intlungu ehlobene ne-endometriosis.
I-Depopo Provera Incedo Yiphatha I-Endometriosis Pain?
Iprogesin kwiDepo Provera icingelwa ukuba incede ukukhusela ukukhula kwezicubu ze-endometri kwaye kwaye kunokunciphisa ukuvuvukala kwe-endometriosis.
Ngexesha lexesha eliqhelekileyo lomjikelezo wokuya esikhathini, ama-hormone akho enza ukuba umbane we-uterus yakho uqhube ukulungiselela ukukhulelwa.
Ukuba awukhulelanga, umgca wesibeletho sakho uhamba, kwaye ugaye (yilokho ebangela ixesha lakho). Ama-hormone alawula umjikelezo wakho wokuya esikhathini ngokusemthethweni aphakame aze awele kulo mjikelezo wakho. Ukunyuka nokuwa kungabangela iimpawu ze-endometriosis zibe zibi kakhulu. Kwakhona, ukuba unayo i-endometriosis, xa unesithuba sakho, ukuphuma kwegazi akuveli kuphela kwimbumba yesisu - iisisu ze-endometrial ezikhulile ngaphandle kwesibeletho sakho ziyahlamba. Xa eli ligazi lichaphazela ezinye izitho, kunokubangela ukonakala kunye nokuvuvukala okubangela ukuba buhlungu.
Ukusetyenziswa kweDepo Provera kuvumela amazinga akho e-hormone ukuba ahlale ezinzile kulo lonke umjikelezo wakho. Kunceda ukuthoba umgca wesibeleko-oku kungakhokelela kwixesha lokukhanya okanye akukho nanye. I-Depo Provera inokuthi ikhusele i- ovulation kwaye iyancipha inani le-estrogen ejikelezayo emzimbeni wakho. Ingcamango apha kukuba ukunyuka kwe-estrogen engaphantsi kwe-endometriosis tissue ifunyenwe, into engaphantsi kweseli iyenzeka. Oku kunciphisa izinga lokukhula kweethambo. Njengoko umgca wesibeleko usabela kula mazinga e-hormone, izicubu ze-endometriosis zenza njalo.
Ziziphi ezinye iiMedi ezenza i-Endometriosis?
Ngaphambi kokuba kusetyenziswe unyango lwe-hormone (njengoDepo Provera) kunyango lwe-endometriosis, i-GnRH i-agonists (njenge- leuprolide ) ibe yipilisi ephambili echanekileyo ekupheleni kwe-endometriosis-relief relief.
Esi sidakamizwa siyi-hormone eyenziwa ngokwemvelo, eyaziwa ngokuba yi-hormonone ekhupha i-gonadotropin, enceda ukulawula umjikelezo wesini. Xa usebenzisa i-leuprolide, ngokuyisiseko iyayeka yonke i-hormone kunye nomsebenzi we-ovari. I-Leuprolide nayo idibaniswa nemiphumo ebalulekileyo, eminye yayo ibandakanya:
- Izimpawu ze-Vasomotor (ukutshisa okutshisa, ukuphalaza, ukujuluka)
- Ukulahleka kwethambo
- Izimpawu ze-Hypostrogenic (ukuma komlanjeni, ukuguquka kwemizwelo, ukuphazamiseka kokulala)
- Intloko
- Ukuxinezeleka
- Ukunciphisa libido
Uphando uthini ngoDepo Provera kunye neLeuprolide?
Esinye sezifundo ezaziwa kakhulu kule ndawo ziqhathanisa iDepo-subQ Provera 104 kunye nokusetyenziswa kwe-leuprolide kuma-257 amabhinqa afunyaniswe i-endometriosis.
Kwakukho abafazi abangama-153 abasebenzisa iDepo-subQ Provera 104 no-146 abafazi abasebenzisa i-leuprolide ngexesha leenyanga ezili-6. Iziphumo zabonisa ukuba:
- I-Depo-subQ IPprovera 104 ikwafana ngokufanelekileyo ekuphatheni iintlungu ezibangelwa yi-endometriosis njenge-leuprolide.
- Iimbini ze-Depo-subQ Provera 104 kunye nokusetyenziswa kwe-leuprolide kunciphise intlungu kwiimpawu ezinhlanu eziphambili ze-endometriosis: ubuhlungu be-pelvic, i- dysmenorrhea , ubuhlungu be-pelvic, i-dyspareunia (ubulili obubuhlungu), kunye ne-induration (ukuqina nobunzima beethambo).
- Emva kweenyanga ezili-6 zokusetyenziswa, i-Depo-subQ Provera 104 yabangela ukulahlekelwa kwesithambiso samathambo angaphantsi kwe-leuprolide. Kwiinyanga ezili-12 emva kwonyango, amanqanaba okulahlekelwa ngamathambo abuyele kumanqanaba angaphambi kokunyangwa kwe-Depo-subQ Provera 104 abasebenzisi, kodwa kungekhona abo basebenzisa i-leuprolide.
- Bobabini imishanguzo efana negalelo ekuphuculeni okubonakalayo kumgangatho wobomi kunye nokuveliswa kwemveliso.
Abaphandi baphetha ngokuthi i-Depo-subQ Provera 104 iyakhathaza intlungu eyenziwa yi-endometriosis ngokuphumelelayo njenge-leuprolide. Kodwa abafazi abasebenzisa i-Depo-subQ Provera 104 babika i-vasomotor engaphantsi (njengotshisa elitshisayo okanye i-sweats) iimpawu kunye neempawu ze-hypoestrogenic (ezifana nokuphazamiseka kokulala, ukuguquka kwemizwelo, kunye nesisindo somzimba) kunye nolwazi olunciphise kakhulu kwi-bone mineral power above the women's use of leuprolide. Ngoko ke, kungekuphela kuphela ukukhulelwa komsebenzi , iDepo-subQ Provera 104 ifanelekile kwaye isebenzise ukhetho lweyonyango njengoluhlu lwe-leuprolide kunyango lweentlungu ze-endometriosis.
Uphando olongezelelweyo luqinisekisa kwakhona ezi ziphumo. Enyanisweni, abaphandi baphonononge zonke iiphando eziphandle ukusetyenziswa kweprogesin kwonyango lwe-endometriosis epapashwe kule minyaka elishumi edlulileyo (1993-2003). Iziphumo ezidibeneyo zonke ezi zifundo zibonise ukuba i-medroxyprogesterone i-acetate, i-progestin kwi-Depo Provera isebenza ngokufanayo njenge-GnRH agonists (leuprolide) ekunciphiseni intlungu ye-endometriosis kunye nokuphucula umgangatho ochaphazelekayo wempilo yobomi. Ababhali baqhubeka bachaza ukuba iDepo Provera isebenzise kwabasetyhini abane-symptomatic endometriosis kwabangela ukuhla kwexabiso elibonakalayo kwiimpawu zentlungu kwaye kukhokelela ekunciphiseni ukukhula kweetometerriosis.
I-Depo Provera njenge-Endometriosis unyango: Igama lokugqibela
UDepo Provera isetyenziselwe ukuphatha ngempumelelo i-endometriosis. Isizathu esibalulekileyo sokusebenza kwayo kukuba iDepo Provera inokukunceda ukukhusela i-ovulation . I-Depo Provera ichaphazela ngokuthe ngqo izicubu ze-endometrial ngokuyibangela ukuba ibe yincinci-oku kukukhokelela kumanani aphantsi ekuphumeni kwexesha lokuya esikhathini-okukhokelela ekuncediseni intlungu.
Nangona kunjalo, iDepo Provera ingaba yonyango lonyango lwe-endometriosis. Nangona isebenza ngempumelelo kwixesha elifutshane, emva kokumisa uDepo Provera, kukho ithuba eliphezulu lokuba ukukhula kweetometerrial tissue kuza kubuya. UDepo Provera akayikunyanga ukungabikho komntwana onxulumene ne-endometriosis. Ukuba ufuna ukukhulelwa, utyando lungaba yindlela yokwenza unyango olungcono kwi-endometriosis.
I-Depo Provera iphumelele njenge-leuprolide kunye nezinye i-GnRH i-agonists ekuphatheni intlungu ye-endometriosis. Kodwa, i-leuprolide iyabiza kwaye ihambelana nemiphumo engathandekiyo. Oko kuthethwa, kukho iDepo Provera iza kunye nesilumkiso sebhokisi ebomnyama isilumkiso- xa sisetyenziselwa iminyaka engaphezu kweminyaka emibili, iDepo Provera inokunyusa ukutyunjwa kwamathambo akho (okukhokelela kwengozi yokwanda kwe- osteoporosis ). Ukusetyenziswa kweDepo Provera kunokukhawuleza ukubuyiswa kokuzala kwakho (malunga ne-50% yabasetyhini baya kukwazi ukukhulelwa kwisithuba seenyanga ezili-10 emva kwejoyi yokugqibela yeDepo Provera, kodwa kungathatha iinyanga ezili-18 ukuze kubuyele ukuzala ). Abanye besetyhini babika ukuphaphazeka okungaqhelekanga okanye okuqhubekayo xa usebenzisa iDepo Provera kunye nezinye iimpembelelo ezingafunekiyo . Ngelishwa, xa unikwe i-injection ye-Depo Provera, ukuba awuhlali ujongene nemiphumo emibi, kufuneka ulinde ixesha leenyanga ezintathu ukuya kuthi zonke i-hormone ezivela kule nkqubo yokukhusela ishiya umzimba wakho. Ngoko ukuba ucinga ukusebenzisa i-Depo Provera njengendlela yokwenza unyango kwi-endometriosis yakho, qiniseka ukuba uthetha ugqirha wakho , ngoko ke unokwazi ukuba ngaba u-Depo Provera unokunika ingxaki ngaphezulu kwezi mngcipheko.
Imithombo:
I-Crosignani PG, uLuciano A, uRay A, noBergqvist A. "I-depotaneous medroxyprogesterone i-acetate kunye ne-leuprolide acetate ekwenzeni unyango lwe-endometriosis." Hum. Ukuhlambalaza. 2006; 21 (1): 248-256.
I-Vercellini P, i-Fedele L, i-Pietropaolo G, i-Frontino G, iSomigliana E, ne-Corsignani PG. "IiProgestogens ze-endometriosis: Phambili kwixesha elidlulileyo." Ukuhlaziywa kwe-Hum Reprod 2003; 9: 387-396.