I-Endometriosis yimiqathango apho izicubu eziqhelekileyo zingena ngaphakathi kwimbilini (i-endometrium) ikhula kwezinye iindawo zomzimba. Yibangela intlungu, ukuphuma kwegazi ngokungenasiphelo, kunye nokungenakucala. I-Endometriosis yinkinga eqhelekileyo kwaye mhlawumbi iqala malunga nexesha eliqhelekileyo lokuya esikhathini. Inkunkuma ye-Depo-subQ Provera 104 iye yavunyelwa yi-FDA ukunceda ukuphatha intlungu ehlobene ne-endometriosis.
Ezinye izityalo zokukhusela i-hormonal zinokunceda ngokunjalo.
Nangona abafazi abangama-80% base-US baya kusebenzisa ukukhulelwa kwe-hormonal ( njengePilisi ) ngexesha elithile ngexesha lokuzala kwabo, abaninzi abanakuqonda iingeniso ezingenakuyamkela zokusebenzisa lolu hlobo lolawulo lokuzalwa. Iiproductive zeHormonal ziqulethe iprogesin , i-estrogen, okanye zombini.
Ukusebenzisa ukukhulelwa kweHormonal ukuphatha i-Endometriosis
Ezinye zezo zithintelo ziye zabonisa amandla okunciphisa intlungu ehlobene ne-endometriosis. Oko kubalulekile, kubalulekile ukuqaphela ukuba isizathu esona sizathu sokusebenzisa ukukhulelwa kwe-hormonal kukukhusela ukuzalwa (ukukhusela ukukhulelwa okungalindelekanga ) - iingeniso ezingenakwamkelekanga zingacingwa xa uthatha isigqibo sokuba yeyiphi indlela yokulawulwa kokuzalwa kwe-hormonal efanelekileyo. .
Ezi zilandelayo uluhlu lweendlela ezahlukeneyo zokulawulwa kokuzalwa komzimba eziye zaboniswa ukuba ziphumelele ekunciphiseni ezinye iintlungu ezihlobene ne-endometriosis:
- UDepo Provera noDepo-subQ Provera 104 : Bobabini baboniswe ukunciphisa intlungu ebangelwa yi-endometriosis. Inkunkuma ye-Depo-subQ Provera i-104 yindlela yokuqala yokulungisa kwimizuzu eyi-15 edlulileyo ukuba i-FDA-yamkelwe ukunyanga intlungu ye-endometriosis. Ngokomphando owenziwe nguPfizer, umenzi weDepo Provera, uDepo-subQ Provera 104 uphatha intlungu ye-endometriosis ngokuphumelelayo njenge-leuprolide, kodwa inxulumene neempawu ezincinci ze-vasomotor (njengobusuku obushushu okanye i-sweats) kunye nokulahleka kwethambo elingaphantsi. Enyanisweni, i-Depo Provera yenze intlungu efana neyo-leuprolide kuzo zonke iindawo ze-endometriosis ezichaphazelekayo-intlungu ye-pelvic, ubuhlungu be-pelvic, i-dysmenorrhea, ubulili obubuhlungu, kunye nobunzima be-tissue.
- Implanon : Oku kuveliswa kokukhulelwa kuye kwaboniswa ukunciphisa intlungu ngenxa ye-endometriosis. Nangona ingaziwa ngokucacileyo indlela i-progestin (etonogestrel) e-Implanon inceda ekunciphiseni iimpawu ze-endometriosis, kucingelwa ukuba isebenze ngokunciphisa ukukhula kweimplantshi ze-endometri, oko kubangele ukuba bahlise kancane. Iprogesin inokunceda ekunciphiseni ukuvuvukala kwesibeletho esibangelwa yi-endometriosis (ngaloo ndlela unikezela ukukhululeka entlungu).
- I-Mirena : I-Mirena IUD iboniswe ukuba incede ekuphatheni i- dysmenorrhea kunye nobuhlungu obungapheliyo buhlungu be-pelvic obuhlobene ne-endometriosis-nangona ayizange ivunyiwe yi-FDA. Ngenxa yokuba i-Mirena inokushiywa endaweni ukuya kwiminyaka emihlanu, le-IUD inika ithuba lokuba yinkqubo ye-endometriosis yexesha elide kubafazi abafuna ukuyeka ukukhulelwa. Izilingo ezincinci zeekliniki ezincinci ziye zaphanda ukuphumelela kwe-Mirena IUD malunga nokunyangwa kwe-endometriosis; olu phando lubonise ukuba iMirena inokuba luncedo ekunciphiseni ubuhlungu bexesha ngaphezu kweminyaka emithathu, kwaye uninzi lwentsebenzo lukwimizuzu eyi-12-18 yokuqala. I-Mirena icingelwa ukuba incedise ukunciphisa inani lokuhamba kwegazi ngelixesha lebhinqa, elinokukunceda ukunciphisa intlungu ye-endometriosis. Enyanisweni, kwabasetyhini abanqwenela ukufumana i-intrauterine contraception, i-Mirena IUD ngoku i-FDA-yamkelwe ukuphatha ixesha elibi.
- Iipilisi zokuLawula ukuzalwa koPhulo olongezelelweyo : Iipilisi zokulawula ukuzalwa ngokuqhubekayo ( njengeLybrel okanye iSeasonique ) zinokunika inzuzo eyongezelelweyo yokuphelisa okanye ukunciphisa amaxesha kunye ne-dysmenorrhea ehambelana ne-endometriosis. Nangona kunjalo, kukho idatha echanekileyo ukubonisa ukuba ukudibanisa iipilisi zokulawula ukuzalwa kunokunciphisa ubunzima be-dysmenorrhea kubasetyhini abane-endometriosis.
> Imithombo:
> Jain, J. (2005). "Ulwaphulo-mali: I-depot-medroxyprogesterone i-acetate yokulawula ukuzalwa kunye nentlungu ye-endometriosis". UBG Management, Vol. 17, ayi-8 . Kufumaneka ngokubhalisa kwangasese.
> Lockhat FB, i-Emembolu JO, i-Konje JC. "Ukuphumelela, iziphumo ezisecaleni kunye nokuqhubela phambili kwimiba yabasetyhini abane-symptomatic endometriosis ephantsi kwonyango kunye ne-intra-uterine ephethwe yi-progestogen (levonorgestrel): Ulandelelwano lweminyaka emithathu." Hum Reprod 2005; 20: 789-93.
> Pfizer. (2005) "iDepo-SubQ Provera 104."
> Pfizer. (2004) "UDepo Provera: Injection yokukhulelwa."
> Schweppe, KW. "Indawo yangoku ye-progestins ekwenzeni izikhalazo ezihlobene ne-endometriosis." Gynecol Endocrinol 2001; 15 (S6): 22-8.
> Sullivan, M. (2005). "Unyango olutsha olwamkelekileyo lwentlungu ye-endometriosis". Iindaba ze-OB / GYN .
> Surrey, ES. "Indima yeepestins ekuphatheni intlungu ye-endometriosis." J Min Gynecol eyabandakanyekayo 2006; 13: 528-34.
> Vercellini, P., Fedele, L., Pietropaolo, G., Frontino G, Somigliana, E., Corsignani, PG. "IiProgestogens ze-endometriosis: Phambili kwixesha elidlulileyo." Ukuhlaziywa kwe-Humproproduced 2003; 9: 387-96.