Ngaba i-Oxide ye-nitric ehamba kule miqathango?
Abanye abaphandi bacacisa ukuba ukugula okungapheliyo (i-CFS okanye i- ME / CFS ) kunye ne- fibromyalgia (i-FMS) inokubangela into efanayo. Omnye umphandi uthi isizathu si-nitric oxide kwaye ikwajongene nokukhathazeka kwamakhemikhali amaninzi (MCS) kunye ne-post-traumatic disorder disorder (PTSD).
UMartin Pall, i-PHD, nguprofesa we-microbiology eYunivesithi yaseWashington State kwaye waqala ukukhangela kwi-ME / CFS emva kokufunyaniswa ukuba nayo.
Ingundoqo yeengcamango zakhe kukuba izixinzelelo zangexesha elifutshane zidala ukwakhiwa kwe-nitric oxide ngokwemveli, eqala umjikelezo onobungozi kwaye ikhokelela ekuguleni kwexesha elide.
Kubalulekile ukuba ukhumbule ukuba le protocol iyalinga kwaye ayisenzulululwazi. Inani elinyukayo lophando, nangona kunjalo, lixhasa inkcazo yeendlela ezingasebenzi kakuhle, kunye nabanye abantu abaye bazama le protocol bathi baye basebenzela.
Ingcaciso apha ayijoliswanga kukuxhasa okanye ukuphikisa ingcamango kaPall kodwa ulapha ukukwazisa malunga neengcamango ezikhoyo kunye neenkqubo zonyango ukuze wenze izigqibo ezinolwazi. Kubalulekile ukufaka ugqirha wakho kwizigqibo zonyango kwaye uhlolwe nayiphi na inguqu kwimpilo yakho.
I-oxide ye-nitric kwiQumrhu lakho
I-oxide ye-nitric (NO) iphela emzimbeni wakho kwaye idlala indima ebalulekileyo njengefuthe ekuthuthweni kwe-oksijini kwiimfucu zakho kunye nokuhambisa iimpembelelo zentliziyo.
Kuze kube sekupheleni kwee-1990, nangona kunjalo, kwakucingwa ukuba i-toxin kunye no-Pall ibona i-toxin kwimfundiso yakhe. Izifundo ezininzi zibonisa utshintsho kwiinkqubo ezinkulu zeentlanzi zabantu abane-FMS kunye ne-ME / CFS, kunye no-Pall uthi ezo zinguqu ziza kufuna amazinga aphezulu a-CHA.
U-Pall uthi uphakamise amazinga amanqanaba kwinqanaba le-nervous central, ekukho ke, likhokelela kumanqanaba aphakamileyo e-peroxynitrite, ebangela ukuba umonakalo wezicubu.
Ufumana njani u-NO kakhulu emzimbeni wakho? I-Pall ikhiphe i-12 engabangela uxinzelelo, 8 ekhokelela ekunyusweni ngokuthe ngqo, 4 ekhokelela kumntu ongathanga ngqo. Abaxinzelelo ngqo:
- Usulelo lwe-Viral (ME / CFS, FMS)
- Usulelo lwebhaktheriya (ME / CFS, FMS)
- Ukukhathazeka ngokwenyama (ME / CFS, FMS, PTSD)
- Ukuboniswa kwe-carbon monoxide (ME / CFS)
- I-Organophosphorus i-pesticide exposure (ME / CFS, i-MCS)
- Usulelo lwe-Toxoplasmosis (ME / CFS)
- Ukuchithwa kwe-organic solvent (MCS)
- Izifo ezizimela ngokuzenzekelayo (i-FMS yesibini)
Ezinye izixinzelelo ezine zenza impendulo ekhokelela ekunyuseni umsebenzi we-NMDA wokufumana umsebenzi, owaziwayo ukwandisa ama-NO kunye ne-peroxynitrite (ONOO-). (I-NMDA receptors ithumela iimpawu kwiingqondo kwaye ingabandakanyeka kumonakalo weseli.) Ezi zixinzelelo zi:
- Ukuxinzezeleka kwengqondo kwengqondo (FMS, PTSD)
- Ukugqithiswa kwe-Ciguatoxin (ukusuka kwintlanzi yokutya) (ME / CFS)
- I-Organochlorine pesticides (MCS)
- I-Pyrethroid pesticides (MCS)
Qaphela: Akunamanqanaba okwandisa ngenxa yezinto ezithile ezintle, njengokuba xa usebenzisa, udla ukutya okunamafutha aphantsi, ukuphucula isondlo sakho okanye ukuyeka ukutshaya, zonke iingcali zijonga inzuzo kubantu abaneFMS ne-ME / CFS. Abaphandi abaninzi bacinga ukuba akukho manqanaba aphezulu okuba ayenzele impilo yakho.
Uluhlu olukhuselekileyo
U-Pall ucebisa ukuba xa uxinzelelo lubangela ukuba kwakhiwe i-NO, iqhubela phambili umjikelezo onobungozi oququzelele amacwecwe amaninzi.
Ukusuka apho, kufumana ubuchwepheshe obunzima kwaye kunzima ukuyiqonda ngaphandle kokuba unolwazi olwenene malunga ne-biochemistry. Ukuba ukhona, uPall unomzobo opheleleyo kwiwebhusayithi yakhe. Konke thina, nasi umzekelo wendlela enye ye-step-step loop esebenza ngayo:
- Iphakamileyo INANI ayikhuphuli izinga le-peroxynitrite;
- Ukwandiswa kwe-Peroxynitrite kubangela uxinzelelo lwe-oxidative (ukwakheka kwee-molecules ezonakalisa iiseli. Izifundo zidibanisa uxinzelelo lwe-oxidative kwi-ME / CFS);
- Uxinzelelo lwe-oxidative luvuselela i-NF-kB (elawula ukubonakalisa izakhi zofuzo ezibandakanyeka kumsebenzi wokuzikhusela kunye neselula);
- I-NF-kB ikwandisa ukuveliswa kwe-enzyme iNOS (inducible nitric oxide synthase);
- I-iNOS yanda iYANYE, kwaye sibuyele kwisinyathelo esinye.
U-Pall uye wachaza umjikelo onobuqhetseba umjikelo we-NO / ONOO- (ochazwe "akukho, hayi!"). Uthi kwenzeka ntoni kumgangatho wamaselula, kungenxa yeso siviki esinye sinokubuhlungu xa zijikeleze. Kwakhona kuchaza ukuba kutheni iimpawu zingahluka ngokubanzi ukusuka komnye umntu ukuya kwelinye.
Izimpawu ezabelwana ngazo
U-Pall uthi iziganeko ze-NO / ONOO-umjikelezo zingachaza impawu ezininzi ezihlanganyelwe yiCFS, i-FMS, i-MCS kunye ne-PTSD. (Uyabanika njengezizathu ezibonakalayo , ezingabonakaliyo.) Le mpawu ibandakanya:
- Ukufunda nokukhunjulwa kwememori,
- Ukukhathala nokuphazamiseka kokulala,
- Ubuhlungu obungapheliyo,
- Ukuxinezeleka kunye nokuxhalabisa / ukuhlaselwa koyika,
- Ukungasebenzi komzimba,
- I-irritable bowel syndrome,
- Ukutya,
- Ukungathembeki kwe-Orthostatic / hypotension (ukulahla uxinzelelo lwegazi xa ukuma kukukwenza udibanise.)
Ukuqhawula umjikelo
Ukuphula umjikelezo, u-Pall uthi kufuneka "ukulawulwa phantsi," oko kuthetha ukuba uyayicutha ngokuphelisa izinto ezibangele. Ngokomzekelo, ukuba uxinzelelo lukwenza uzive lubi kakhulu, kufuneka linciphise okanye lulawulwe. Ngaphandle koko, ukholelwa ukuba ubunzima bomjikelezo kufuna iindlela ezahlukeneyo zonyango.
Iphepha lePall kwi-NO / ONOO- umgca uchaza inkitha yezinto-ezininzi zazo izongezelelo zondlo - ukuba uqikelela ukuba uya kulawula umjikelezo. (Khumbula ukuba le ngqungquthela engavumelekanga kwaye la ma-agent angenakunyangwa ukuphathwa kweli qela lezifo.) Ukwahlula kwakhona iinkqubo zonyango ezisetyenziswe oogqirha abahlanu abaye bafumana impumelelo yokuphatha enye okanye ngaphezulu kwezi meko kwaye bathi zonke izifo zonyango ziya lawula umjikelo. Njengazo zonke iinketho zokonyango, kufuneka uxoxe nodokotela wakho malunga nento efanelekileyo kuwe.
I-Pall ayilona yedwa ekhomba i-nitric oxide njengesisisiseko sezi zifo. Abaphandi abaninzi abavavanya inxaxheba ye-NO, ngokukodwa kwi-fibromyalgia, bafuna iifundo ukuba ingaba i-antioxidants yonyango olululo.
Uphando
Ukususela kwincwadi kaPall echaza ingcamango yakhe yavela ngo-2007, inani elincomekileyo lophando lwenziwa kwendima ye-nitric oxide kule miqathango.
Kwi-ME / CFS, izifundo ezininzi (Sachdeva, Kumar, Gupta) zivele zixhasa ukufundiswa kweengcamango, ubuncinane kwimimodeli yamagundane.
Ezinye izifundo zabantu zibolekisa ukuthembeka, kubandakanywa nophando lwango-2010 (uSuarez) olubonisa ukungabikho kwe-metabolites engavumelekanga emva kokusebenzisa eM ME / CFS. Uphando olushicilelwe ngo-2014 (Morris) lubonisa ukuba uxinzelelo lwe-oxidative kunye ne-nitrosative lungakhokelela iindlela zokuzikhusela ezikhuselweyo kunye nezindlela ezizimelayo ezigcina izifo zesifo.
Nangona kunjalo, ubuncinane isifundo esisodwa (Meeus) asifumananga ukusebenzisana phakathi kwemali engekho kwigazi nomsebenzi kwi-ME / CFS.
Izifundo eziliqela (iCimen, iFatima, i-Sendur) nazo zixhasa inkxaso ye-nitric oxide inxaxheba kwi-FMS. Omnye (uKim) akafumani mmahluko ophawulekayo kumanqanaba phakathi kweqela le-FMS kunye nokulawula okunempilo.
Ngaba iProtocol ye-Pall ikulungele?
Nguwe kuphela onokugqiba isigqibo sokuba unyango lulungile kuwe, kwaye kufuneka uqiniseke ukuba uxoxe ngamanyathelo akho unyango kunye nogqirha wakho. Ukongeza kwimiba emininzi yale protocol efuna ukuthatha inxaxheba kwidraka, kufuneka uhlolwe ngokugqithiseleyo ukuqinisekisa ukuba unyango alunayo ingozi kwimpilo yakho.
Imithombo:
Cimen OB, kunye no-al. Iimpawu zobuhlungu. 2009 Julayi-Aug; 10 (5): 813-8. I-Arginase, imisebenzi ye-NOS, kunye neempawu zekliniki kwizigulane ze-fibromyalgia.
UFatima G, iDas SK, i-Mahdi AA. I-rheumatology yeklinikhi kunye nokuhlola. NgoNovemba ka-2013 uNgo-Dec; 31 (6 I-Suppl 79): S128-33. Uxinzelelo lwe-oxidative kunye ne-antioxidative parameters kunye ne-ion content content kwizigulane ezine-fibromyalgia syndrome: iziphumo kwi-pathogenesis yesifo.
I-Gupta A, i-Vij G, i-Chopra K. I-Journal ye-neuroimmunology. 2010 Septemba 14; 226 (1-2): 3-7. Indima enokubakho yoxinzelelo lwe-oxidative kunye nokusebenza kwe-immunological kwimodeli yemouse yesifo esingapheliyo yokugula kwaye i-ttenuation yi-extract.
Kim SK, et al. I-rheumatology yeklinikhi kunye nokuhlola. Ngo-2010 uNgo-Dec, 28 (6 iSongezelelo 63): S71-7. Ukuqina kobungozi kunye nama-cytokines ahlalutyo kwi-fibromyalgia syndrome.
Kumar A, et al. Umbhalo we-Indian of pharmacology. NgoNovemba ka-2011; 43 (3): 324-9. Imodyuli ye-oxitri ye-nitric inendima ekhuselekileyo kwi-anti-depressants yokulwa nesifo esingapheliyo sokugula.
UMartin L. Pall, iSikole seMolocular Biosciences, kwiYunivesithi yaseWashington State. Onke Amalungelo Agciniwe. "Isifo seNveve iParadigm Ivelisa Iinkcazo zeQela Elipheleleyo leZifo."
Meeus M, et al. In vivo. Ngo-2010 uNgo-Dec; 24 (6): 865-9. Iziphumo zee-oxide ziqhelekileyo kwaye azihambelani nomgangatho womsebenzi kwi-syndrome engapheliyo.
UMorris G, uMaes M. Okwangoku i-neuropharmacology. 2014 Mar; 12 (2): 168-85. Uxinzelelo lwe-oxidative kunye ne-nitrosative kunye neendlela zokuzivikela emzimbeni kwizigulane ezine-myalgic encephalomyelitis (ME) / i-chronic fatigue syndrome (i-CFS).
Sachdeva AK, Kuhad A, uChopra K. Brain uphando lweengxelo. Ngo-2011 Oktobha 10; 86 (3-4): 165-72. I-Epigallocatechin gallate iphakamisa ukulahleka kokuziphatha kunye ne-biochemical kwi-rat model ye-load-inculated fatigue syndrome.
I-Sendur OF, et al. Rheumatology ngamazwe ngamazwe. 2009 uMbhi; 29 (6): 629-33. I-serum antioxidants kunye namazinga e-nitric oxide kwi-fibromyalgia: isifundo esilawulwayo.
Suarez A, et al. Umbhalo wezempilo yabasetyhini. 2010 Juni; 19 (6): 1073-7. Ukuveliswa kweemetabolite ze-nitric ngexesha lokuzivocavoca kwi-syndrome engapheliyo.