Ikhonkco phakathi kwe-Aspirin ne-Asthma
Uninzi lwabantu alucingi kabini malunga nokuphuma kwe- aspirin xa baneentloko. Kodwa kwabanye abantu abane- asthma , le mpendulo elula ingaba yingozi.
Yintoni i-Aspirin-Induls Asthma?
I-Aspirin kunye nezinye izidakamizwa ezichasene nezidakamizwa (i-NSAIDS) ezifana ne- ibuprofen , naproxen, kunye ne-diclofenac sele zifunyenwe ukuba zenze ukuhlaselwa kwe-asthma kubantu abane-asthma.
Ukuhlaselwa kwe-asthma eyenziwa yi-aspirin kunye ne-NSAIDS kaninzi kunzima yaye kunokusongela ubomi. Uphuhliso lwe-aspirin lubonakala landa njengoko abantu bebudala, kwaye kubi ngakumbi kubantu abane-asthma.
Le syndrome iye yaqaphela iminyaka emininzi, kodwa yayingacacanga ukuba bangaphi abantu abane-asthma babenomngcipheko xa bethatha la mayeza aqhelekileyo kusetyenziswe ukuba kwenziwe izifundo.
Uphononongo olukhulu lwango-2004 luhlaziye uphando olwenziwa kwi-asthma eyenziwa yi-aspirin (i-AIA efutshane). Abaphandi bamangaliswa ukubona ukuba ama-5 ekhulwini kwabantwana abane-asthma kunye neepesenti ezingama-21 zabantu abadala abanesifo se-asthma bafumana i-AIA.
Iziphumo zolu cwaningo zibalulekile kuba abantu ababandakanyekayo babe "banzima" kunye ne-aspirin kwisimo esilawulwayo, esenze ukuba kuqikelelwa ngokuchanekileyo kubangaki abantu abachaphazelekayo yi-AIA. Le ndlela yokuqhuba isifundo iyancitshisa amathuba okuba abantu babeza kuthi ukuhlasela kwabo isifo se-asthma kwisifo ababethabatha i-aspirin, into eyenziwa ngabaphandi eyenzeka rhoqo.
Enyanisweni, abaphandi bafumanisa ukuba xa abantu bebuzwa ukuba baxelele ukuhlaselwa kwe-asthma kwangaphambili kwe-aspirin, izinga leempendulo ezintle li-2.7 ekhulwini kuphela.
Kutheni iApirin Ngamanye amaxesha yenza ukuba i-Asthma ihlasele?
Oogqirha nabaphandi babekholelwa ukuba le nto yayiyimpembelelo ye - aspirin.
Nangona kunjalo, ngoku kukholelwa ukuba i-aspirin ibangela ukuhlaselwa yi-asthma kwabanye abantu kuba i-aspirin isebenza njenge-deregulator of leukotrienes. I-Leukotrienes yinto ebonakalayo emzimbeni obangela ukuvuvukala kunye nempawu ezininzi ze-asthma.
Ngaba kukho iAspirin Substitutes ezikhuselekileyo kubantu abane-AIA?
Abantu abane-AIA nabo basengozini yokuphendulwa kwe-asthmatic kwi-NSAIDS, eyona mayeza oogqirha ahlala ewalela abantu abaphikisayo kwi-aspirin. Uphando lufumene ukuba phantse bonke abantu-abo banayo i-AIA banemiphumela engalunganga kwi-NSAIDS. Ubuhle bokuhlaselwa kwesifo se-asthma kubuninzi kubantu abaye basabela kwiimeko ezincinane ze-aspirin.
Izigulane nge-AIA nazo zavavanywa ukuze zibone indlela eza kuphendulwa ngayo kwi-acetaminophen (iTylenol), enye indawo engafanelekileyo ye-aspirin. Ngaloo mayeza, iipesenti ezi-7 kuphela zabantu abane-AIA babenempendulo yokuphefumula. Kwakhona, abo babenomdla kakhulu kwi-aspirin babenokwenzeka ukuba basabela kwi-acetaminophen.
Olunye udidi lweentlungu zokuxilisa ubuhlungu, i-anti-inflammatory cyclooxygenase-2 (COX-2) inhibitors ezifana ne-celecoxib (Celebrex), yenza ngendlela echasene ne-infirmatory kune-aspirin ne-NSAIDS. Ngenxa yokuba ezi ziyobisi zijoliswe kancinci kwindlela yokuvuvukala, azibonakali zibe nempembelelo efanayo kubantu abane-asthma.
Nangona i-COX-2 inhibitors ayinayo impembelelo embi yokunciphisa ukuhlasela kwe-asthma ezifana ne-aspirin kunye ne-NSAIDS, izidakamizwa ze-COX-2 ezivimbelayo zinokunyusa umngcipheko wokuhlaselwa intliziyo kunye nesifo. Abantu abane-AIA kunye nabafuna imithi echasene nokuvuvukala kufuneka bathethe nodokotela wabo malunga nobungozi kunye neenzuzo ze-celecoxib.
Unyango kunye nokuthintela i-Aspirin-I-asthma
Abantu abane-AIA bathambekele ekuphuhliseni iimpawu zingakapheli imizuzu engama-30 ukuya kwiiyure ezingama-2 emva kokuthatha i-aspirin okanye i-NSAIDS, kwaye ubunzima obunokuphefumla buhlala ixesha elide. Unyango lufana nelo naluphi na ukuhlaselwa kwe-asthma echaphazelekayo-ukukhutshwa ngokukhawuleza kwe-inhaler, kunye ne-oxygen kunye ne-steroids kwiimpawu ezinzima.
I-leukotriene modifiers enye uhlobo lweyeza-asthma ezinokuphucula iimpawu kwizigulane ezine-aspirin. Ngenxa yokuba la mayeza ayayeka izenzo ze-leukotrienes, eziye zaboniswa ukuba zidlala indima enkulu e-AIA, ezi zi yobisi, kunye ne-steroids enganyangekiyo, ziqhelekelelwe kubantu abane-AIA.
Indlela efanelekileyo yokuthintela ukuhlaselwa yi-asthma ukunyangwa ngamayeza kukuphephelela ngokupheleleyo i-aspirin kunye ne-NSAIDS. Abantu abane-asthma kwaye abaqinisekanga ukuba baphendule njani kwi-aspirin ngexesha elidlulileyo kufuneka bacele ugqirha wabo ukuba ukhuselekile ukuvavanya uvakalelo kwi-aspirin nakwi-NSAIDS. Oku kufanele kwenziwe kuphela kwisimo esilawulwayo ngenxa yengozi yeempendulo ezinzima.
Abantu abane-aspirin / i-NSAID enobuzwe obunokuthi bathathe i-aspirin okanye imithi echasayo yokunyanga kwezinye iimeko, ezifana nesifo senhliziyo okanye izifo ze-rheumatic, banconywa ukuba bangenwa yi-aspirin. Oku kunokwenziwa ngugqirha ogxininisekile kwi-allergies kunye ne-immunology. Emva kokuba le nkqubo iqhutywe, kubalulekile ukuba umntu uqhubeke ethatha i-aspirin imihla ngemihla, ngoko uya kuhlala engafuni.
Imithombo:
Gyllfors, P., et al. Ubungqina bemizimba kunye neklinikhi yokuba izifundo ze-aspirin-ezingaxhaswanga zifundo ze-asthmatic zinyamezela i-cyclooxygenase 2-ekhethiweyo ye-drug celecoxib. J Allergy Clin Immunol . 2003 ngoMeyi; 111 (5): 1116-21.
Jenkins, C., Costello, J., & Hodge L. Ukuhlaziywa kwesistim e-aspirin kubangele i-asthma kunye neempembelelo zayo kwizonyango. " BMJ 2004 Feb 21; 328 (7437): 434.
Macy, E., et al. Umngeni we-Aspirin kunye nokunciphisa intsholongwane ye-aspirin-yandisa isifo sokuphefumula: Isenzo. Ann Annistry Asthma Immunol. 2007 Feb; 98 (2): 172-4.
I-Heart Heart Lung ne-Blood Institute. ISebe lezeMpilo eMelika kunye neeNkonzo zoLuntu, iiNational Institutes of Health. (Agasti 2007). Ingxelo yePhaneli yeeNkcazo 3: Izikhokelo zoLwazi kunye noLawulo lwe-Asthma: Ingxelo epheleleyo 2007 .