I-Corticosteroid iFomelwe ukuKhutshwa koKhutshwa
URayos ( prednisone ), owaziwa ngokuba yiLodotra eYurophu, ukuqulunqwa kwexesha lokukhutshwa kwe-dose prednisone. URayos, owenziwe ngu-Horizon Pharma, wamukelwa yi-US Food and Drug Administration (FDA) ngoJulayi 26, 2012, ngesifo se-rheumatoid kunye nezinye izibonakaliso.
Imvume ye-FDA isekelwe kwidatha efanisa i-pharmacokinetics (oko kukuthi, ukuba isilwanyana sithatha njani, sagqitywa, sichithwa) sikaRayos ukuya kwi-prednisone yokukhululwa ngokukhawuleza, kunye nedatha evela kwi-Circadian Administration ye-Prednisone ku-RA (i-CAPRA-1 ne-2 ) uvavanyo.
I-CAPRA-2 ibonisa ukuba abantu abaneemodareyithithi ezinzulu zesifo se-rheumatoid abaye baphathwa noRayos bafumana ukuphucula okubalulekayo kwi- ACR20 imilinganiselo yeempendulo xa kuthelekiswa ne-placebo, kunye nokuphuculwa okukhulu kwinqanaba lokukhathala. I-CAPRA-1 ihlolwe ukhuseleko jikelele kaRayos.
Iinkcazo
U-Rayos uyi- corticosteroid eneempembelelo ezichasayo okanye izigulane ezingasetyenziswayo ekusebenziseni ukunyanga, i-dermatologic, i-endocrine, isisu, i-hematologic, i-neoplastic, inkqubo ye-nervous, i-ophthalmologic, i-renal, i-breathing, ne-rheumatologic.
Ngokubhekiselele kwiimeko ze-rheumatologic, uRayos angasetyenziselwa ukukhutshwa kwexesha elifutshane leqhekeza elincinci le-arthritis. I-Rayos ingasetyenziselwa kwezinye iimeko ze- spondylitis e-ankylosing , i-dermatomyositis, i-polymyositis, i- polymyalgia rheumatica , i- psoriatic arthritis , ibuyele i-polychondritis, i-rheumatoid arthritis, i- Sjogren's syndrome , i- systemic lupus erythematosus kunye ne- vasculitis .
Ukufumaneka
URayos ufumaneka njengo-1 mg., 2 mg, kunye no-5 mg. ithebhulethi yokukhululwa.
Ukukhetha
Ukuzikhethela kufuneka kube ngabanye ngokucatshungulwa okunikezelwa kwisifo esiqinileyo nokuba ngaba izigulane zisetyenziswa ngokusesikweni kwangoko-prednisone. Umthamo wokuqala usu-5 mg. kaRayos kanye ngosuku. Nangona kunjalo, izigulane ezidlulileyo kwi-prednisone zingadinga ukulungiswa kwenzuliso ukuze zenze okulinganayo xa zisuka kuRayos.
URayos kufuneka athathwe ngokutya, kwaye ithebhulethi kufuneka ifakwe ngokupheleleyo. Ukulondolozwa, i-dose esebenzayo kakhulu kufuneka isetyenziswe. Ukuyeka ukutshintshana kufuneka kufutshane.
Izimpembelelo ezimbi
Ukusetyenziswa kwezinto eziqhelekileyo ezichaphazelekayo kunye nokusetyenziswa kwe-corticosteroid kubandakanya ukugcinwa kwamanzi, ukuphakama kwegazi, ukutshintsha kwimeko yokunyamezela kwe-glucose, ukutshintsha kwemizwelo, ukufumana ubunzima, nokunyusa ukutya.
Kukhona ezinye iimpendulo ezimbi ezinokuthi zidibaniswe neninzi yeenkqubo zomzimba. Ulwazi olupheleleyo olupheleleyo lweRayos luqulethe uluhlu olubanzi. Izimpembelelo ezingalunganga zeMusculoskeletal ezihambisana ne-corticosteroids zibandakanya i- osteonecrosis yeentloko zowesifazane kunye nezobuhlungu, i- osteoporosis , ubuthathaka bomzimba, ukulahleka kobunzima bomzimba, ukuhlukana komzimba kunye nokuphuka kwetonon.
Ukungqinelana
URayos akufanele asetyenziswe zizigulane ezine-hypersensitivity eyaziwayo kwi-prednisone okanye ezinye izithako ezingasebenzi ezingezantsi kwithebhulethi.
Izilumkiso
- Abagulane, ingakumbi abo baphathwa nge-prednisone ixesha elide, kufuneka bahlolwe kwi-hypothalamic-pituitary-adrenal axis suppression, i-Cushing's syndrome, kunye ne-hyperglycemia.
- Kukho ukunyuswa okukhulu kwintsholongwane entsha kwaye kwandisa umngcipheko wokuxhatshazwa okanye ukuvuselela ukusuleleka kweentsholongwane kwizigulane eziphathwe nguRayos okanye i-prednisone.
- Uxinzelelo lwegazi, kunye namazinga e-sodium ne-potassium kufuneka ahlolwe.Ichiza linokuchaphazela ityuwa kunye nokugcinwa kwamanzi.
- Kukho ubuncipheko obuninzi bokukhathazeka kwamathumbu, kuquka ukuphosa. Iimpawu ziyakutyhalwa.
- I-Euphoria, ukulala, ukuguquka kwemizwelo, utshintsho lomntu, kunye nokuxinezeleka okukhulu kunokwenzeka. Ukungazinzi ngokomzimba okukhoyo kunokungahambi kakubi nokusetyenziswa kwe-prednisone.
- Ukunciphisa ukuxinwa kwethambo kunokwenzeka.
- Kukho iziphumo ze-ophthalmic kuquka i-cataracts, i-glaucoma, kunye nosulelo.
- Ukuphila okanye ukuhlala iigcini ezigulisiweyo akufanele zinikezwe izigulana ezithatha i-prednisone.
- Ingozi yentsholongwane ingenzeka ngekota yokuqala yokukhulelwa.
Ukusebenzisana kweziyobisi
URayos unokusebenzisana naye:
- Anticoagulants
- Amachiza anesifo sikashukela
- I-CYP3A4 inducers kunye ne-inhibitors
- Cyclosporine
- Ii-NSAID (izidakamizwa ezingabhubhisiyo)
Qiniseka ukuba ugqirha wakho uyazi zonke iyeza kunye nezibonelelo ezithathayo ngoku. Kubalulekile ukuvavanya umngcipheko onokumelana nokuxhamla okunokwenzeka kwonyango kunye noRayos.
Yintoni eyahlukileyo?
U-Rayos uhlukile njani kwi-prednisone ngokukhawuleza? Kwiimvavanyo zeclini, uRayos wayelawulwa nge-10 ntambama ngokutya. Ubume bokukhululwa kwe-Rayos obunokulibaziseka buvumelekile ukuba inqanaba lokuthathwa kwe-prednisone egazini lenzeke xa amazinga e- cytokine aqala ukwanda phakathi kobusuku. Le ndlela yesenzo inokubonelela ngakumbi ukulawula ukuvuvukala kwezinye izigulane.
Imithombo
Rayos. Ulwaziso loLwazi.
http://www.rayosrx.com/PI/RAYOS-Ukuchaza-Information.pdf
I-Horizon Pharma Izisa i-FDA Ukuvunyelwa kweRAYOS® (prednisone) Iibhulile ezikhutshiwe ezichithwe kwi-Rheumatoid Arthritis kunye neenkcukacha ezininzi ezongezelelweyo. Horizon Pharma. Julayi 2012.
http://ir.horizon-pharma.com/releasedetail.cfm?ReleaseID=695983