Ukunyuka kweempembelelo kwi-tandem kunye nobude bokusetyenziswa
I-Prednisone yipilisi ye- corticosteroid enamandla esetyenziselwa ukunyanga iifom ezinokuvuthayo ze-arthritis kunye nezinye iintlobo zesifo somhlaza kunye nesifo esisodwa . Itholakala kwiifomethe kunye nemisebenzi yamanzi kunye nemisebenzi njenge- immunosuppressant , ukukrakra ngokukrakra ngokugubungela impendulo yomzimba.
Indlela iPrednisone isebenza ngayo
Ukuvuvukala kuyimpendulo yendalo yomzimba nantoni na into eyingozi.
Xa i-immune system ibonakalisa i-arhente elimazayo, ikhupha iikhemikhali egazini egazini eyenza izicubu zikhule, inxalenye yokwandisa ubungakanani bemithambo yegazi kunye nokuvumela ukuba amangqamuzana omzimba amaninzi afumane ukufikelela kwisiza sokulimala okanye ukusuleleka.
Ngeemfuno ezithile zokuzimela, ukuphendula komzimba okungekho mzimba kwaye kungaphezulu. Leyo yimeko ye- rheumatoid arthritis (RA) apho isimiso somzimba sokuzivikela sisenokuhlaselwa ngephutha ngamalungu omzimba. Iimpawu ze-RA eziqhelekileyo zihlala ziphazamisa ngaphandle kwesaziso, zenze intlungu, ukuvuvukala, kunye nokulimala kwintsebenziswano echaphazelekayo.
I-Prednisone inokukwazi ukulawula le mililo ngokukhawuleza ukunciphisa ukuvuvukala deze ezinye iziyobisi ezichasene nezifo (anti-rheumatic drugs) (DMARD) zikwazi ukusebenza. Ngelixa i-DMARD ithanda i- Plaquenil (i-hydroxychloroquine) ne- Arava (i-leflunomide) ijoliswe ngakumbi ekulawuleni i-immune system, iyakwenza ngokukhawuleza.
Ngokwahlukileyo, i-prednisone inokukhawuleza ekuboneleleni ngenkxaso kodwa ineempembelelo ezininzi ezithintela ukusetyenziswa kwayo, ingakumbi kwixesha elide.
Ngokungafani ne-DMARD, i-prednisone ayijolise kwi-cell okanye umsebenzi we-biological. Esikhundleni salokho, isebenza ngendlela, ikhukhula umzimba kwaye ichaphazela iintlobo ezahlukeneyo zeeseli nemisebenzi. Kungenxa yesi sizathu ukuba i-prednisone inokubonelela ngokukhulula ngakwesinye icala kwaye ibangela iingxaki kwenye.
Imiphumela
Imiphumo emibi ye-prednisone inokuqala ukusuka kwi-mild to severe.
Zenzeka ngokuphindaphindiweyo kwimilinganiselo ephezulu okanye kusetyenziswa ixesha elide.
Imiphumo emfutshane yexesha elifutshane ifana neyezinye izidakamizwa ze-corticosteroid kwaye ingaquka ukugcinwa kwamanzi, ukukhushulwa kwesisu, kunye nokwanda kwegazi kwi-glucose.
Iingxaki zivela, nangona kunjalo, xa unyango luqhubeka ixesha elide, likhula ngamandla njengoko ubude okanye umlinganiselo wenyuka. Iziphumo ezinokuthi zibandakanye:
- Igazi elonyukayo
- Ukukhathala okuqhubekayo
- Iimoya zitshintsha, kuquka nentukuzelo engazelelwe
- Ukulahlekelwa ingqalelo okanye ukudideka
- Ukuxinezeleka nokuxhalaba
- Ukungabikho
- Ukutyeba kwakho
- Ukuvuvukala kwebuso
- Ukuya esikhathini
- Isilonda sePeptic
- Umbono ogqityiweyo, i- glaucoma , okanye i- cataract
- Ubuthakathaka obuthathaka kunye ne-atrophy
- Ukucoca okanye isikhumba
- Ukululaza
- Ukwanda komngcipheko wokusuleleka ngenxa yokunyanzelwa kwe-immune
- I-osteoporosis kunye nobungozi obuninzi beentsimbi
- I-Bone ukufa ( osteonecrosis )
- Isifo sesibindi esinyama (i- hepatic steatosis )
- Psychosis
- Ukukhula okunamandla kubantwana
Ulwaziso loLwazi
I-Prednisone ifumaneka kokubili ukukhutshwa ngokukhawuleza kokukhutshwa nokulibazisa. Ukuze unyango lwe-RA kubantu abadala, isiza sichazwe ngale ndlela:
- I-prednisone yokukhululwa ngokukhawuleza imiselwe kwimizuzu yesibini ye-milligrams engaphantsi kwe-10 ngosuku ethathwe nge-DMARD.
- Ukukhishwa kwe-prednisone yokuchithwa kwexesha elimiselweyo kwinqanaba lemilagram emihlanu ukuqala, elilandelwa yimizi yesondlo ephantsi kakhulu yokugcina isiphumo esihle seklinikhi.
I-Prednisone idla ngokuthathwa njengedosi enye ngexesha lesidlo sasekuseni ukuphucula ngcono isisu esiswini.
Kwabantu abane-arthritis enesifo esinamandla, ukuqulunqwa kokukhutshwa kwexesha lokubanjelwa kungathathwa ngexesha lokulala ukunciphisa ukuqina kwentsimbi kunye nentlungu.
Ubungakanani bonyango kufuneka benziwe ngokwamntu ngamnye, ulinganise iingeniso kunye nobungozi kwaye unqume ukuba unyango lwemihla ngemihla okanye oluphakathi lufanelekile.
Ukusebenzisana kweziyobisi
I-Prednisone yaziwa ngokuba neendlela ezininzi zokusebenzisana kweziyobisi. Kwezinye iimeko, izidakamizwa zesibini ziyakwandisa ukutholakala kwe-prednisone kwaye, kunye nayo, ubunzima bemiphumo emibi.
Kwezinye iimeko, i-prednisone inokuphazamisa umsebenzi wesicatshulwa sesibini.
Ukusebenzisana kweziyobisi ngezixhobo ezibandakanya iziyobisi kubandakanya:
- Amayeza anjenge-clarithromycin okanye i-rifampin
- Izidakamizwa ezifana neZoloft (sertraline) kunye neProzac (i-fluoxetine)
- Izidakamizwa zokulwa ne-anti-seizure ezifana ne-carbamazepine kunye ne-phenytoin
- Amachiza antifungal afana neDiflucan (fluconazole) kunye ne-Sporanox (itraconazole)
- Iziyobisi ezinqamlekileyo ezinjenge-Emend (aprepitant)
- Iimfuyo ze-asthma ezifana ne-Accolate (zafirlukast)
- Aspirin
- Igalelo legazi njengeCoumadin (warfarin)
- Diuretics ("iipilisi zamanzi")
- Iipilisi zenhliziyo ezifana ne-verapamil, diltiazem, kunye ne-amiodarone
- Iipilisi zokugcoba njengeTagamet (cimetidine)
- Iyezayeza njenge-Reyataz (atazanavir), i-Crixivan (indinavir), ne-Kaletra (lopinavir / ritonavir)
- Zokukhulelwa kweeHormon
- Izidakamizwa ezingenasifo
- Ezinye i-corticosteroids
- ISt John's Wort
Ukongezelela, i-high-dosage okanye ukusebenzisa ixesha elide le-prednisone kunokunciphisa ukuphendula komzimba kwiimpawu ezithile kwaye zibenze zingasebenzi. Ukuba uye waphathwa kakubi nge-prednisone, kufuneka ulinde okungenani ezintathu kwiinyanga emva kokuyeka ngaphambi kokufumana igciwane lokuphila .
Njalo qiniseka ukuba ucebisa ugqirha wakho kwanaliphi na zonke iziyobisi okanye izongezelelo onokuzithatha, nokuba ingaba yimiyalelo, ayiyiyo imithi, imithi, isondlo okanye imveli.
Ezinye izinto
Ngexesha lokukhulelwa, i-prednisone imele isetyenziswe kuphela xa ifunekayo ngokucacileyo. Akuzange kuboniswe ukuba kubangele intlungu kumntwana wesifundo kwizilwanyana. Isilwayo sinokudluliselwa kwintsana ngenxa yobisi lwebele kodwa ayaziwa kubangela nayiphi na ingozi. Gcina uzinzima kunye neengozi kunye nodokotela wakho ngaphambi kokuqala unyango.
Cetyiswa ukuba ukufakelwa kwamanzi kuqulethe isonka kunye notywala. Ungadinga ukusebenzisa i-tablet ifom ukuba ngaba ezinye zezi zinto zingathinteli imeko yonyango ezifana nesifo sikashukela okanye isifo sesibindi.
Ekugqibeleni, ukuba sele uthatha i-prednisone ixesha elithile, akufanele unqande unyango ngokukhawuleza. Ukubetha isilwanyana ngokukhawuleza kuya kukunceda ukuphepha okanye ukunciphisa iziphumo ezibi ezibangelwa ukupheliswa ngokukhawuleza kwonyango.
> Umthombo:
> Firestein, G .; Budd, R .; UGabriel, S. et al. (2017) I- Kelley ne-Firestein yeBookbook yeRheumatology (10th ed .). Philadelphia, Pennsylvania: Elsevier: ISBN: 9780323316965.