Ngaba i-Splenda Isisitishi esikhuselekileyo seShukela ekuKusweni kweCarcer?
Ingaba i-sweetleneral Splenda (sucralose) yenza umhlaza? Ingaba yindawo ekhuselekileyo yetshukela ekudleni kokuthintela umdlavuza?
Ukuba u-Google umbuzo othi "Ngaba i-Splenda ibangele umdlavuza" uya kufumana iimpendulo zithi kokubili ewe no. Amanye amanqaku acacisa izifundo ezifumene i-leukemia kwiigundane kwaye zithi yee, Ngokwahlukileyo, unokufunda ngezifundo eziqinisekisa ukuba iSplenda ayinyuli ingozi yomhlaza kwaye ikhuselekile, kwanabafazi abakhulelweyo nabancelisayo.
Yiyiphi impendulo echanileyo?
Yintoni i-Splenda (Sucralose)?
I-Splenda, eyaziwa ngokuba yi-sucralose yegama eliqhelekileyo, i-sweeter nutritive e-sweet times engcono kunama-600. Kwakuqala ukuvunyelwa ngo-1998 njenge-table-top top substitute, kwaye ngowama-1999 kwavunyelwa njengenjongo epheleleyo yokuthakazelisa. Ngexesha langoku, i-Splenda iqikelelwa ukuba ikhona kwimveliso engama-4500 eyahlukileyo ukusuka kumxube we-dessert kwisiraphu kwaye ifumaneka kumazwe angama-80.
I-Sucralose yenziwa ngokuqala ngeswekile egciniweyo yamhlophe (sucrose.) Ukwahlukana kukuba kwi-atom ye-chlorine ithatyathwe endaweni efanelekileyo yokubhabhisa i-hydrogen-oxygen bonds. Nangona kukho i-atyrole ngee-athomu ze-klorine kwi-compound (kuba i-chlorine ingaba yingozi engumdlavuza) la ma-athomu e-chlorine awakho kwifomu ebangela ukukhathazeka.
I-Sucralose idibanisa neeseli ze-nerve (i-chemoreceptors) kwindlela yokugaya edlala indima ekuguquleleni kwengqondo yethu into enomdla.
Ukuba udidekile ngabafaki abathintekayo beeshukela okwangoku okwangoku, nasi uqikelelo lwezonkcenkceshe ezenziwayo ezisetyenziswayo eMelika.
Ukuphikisana Ngeziqheno zokuSebenza
Ngokuqinisekileyo kukho ukuphikisana okubandakanya izitishi zentshukela. Umdlavuza onokuthi ujikeleze i-sweeteners ebonakalayo ivela kwii-1970 xa iiliti zeebhanki zavelisa umdlavuza wesisu ngexesha lesilingo se-saccharin.
Nangona kungekho mdla womhlaza kumntu kuthiwa unxulumene ne-saccharin, ihlazo lisahlala kwaye liqhubeka nokuvunyelwa kwe-aspartame (okungenzeka ukuba ixhala ngakumbi kuneSplenda.)
Ngakolunye uhlangothi lwe-equation yinto enkulu yeswekile umyinge waseMelika odlayo-kuthiwa iipaspuni ezingama-22 imihla ngemihla-kunye nezinga lokunyuka kokukhuluphala nesifo sikashukela.
Singazizalisa iveli kunye nezinye iingxabano nakweliphi na icala, kodwa ngeenjongo zethu apha, siza kujonga kwiSplenda (sucralose) yedwa kunye noko sifunde malunga nokuba ngaba akunjalo okanye kungabangela umdlavuza okanye kubakho kwiingxaki zempilo ezonyusa nomngcipheko womhlaza.
Ukuqonda iCarcinogenicity / Genotoxicity
Ngaphambi kokuxoxa ngezifundo, kunceda ukuchaza amagama ambalwa. I-carcinogenicity ibhekisela kwikhono lezinto ezibangelwa ngumhlaza. I-Genotoxicity iyigama elifanayo. Libhekisela kwikhono lomntu ukulimaza izityalo (iigenes ngaphakathi kwe-DNA ephakathi kweseli nganye.)
Iqhekeza iqala ngokuqhelekileyo xa uluhlu lwesiguquko soguquko kunye neminye imonakalo yemfuzo yenza ukuba iseli ihlukane kwaye ikhule ngaphandle kokulawula. Ngamanye amazwi, yi-genotoxicity (ukukwazi ukulimaza izityalo) eziqhelekileyo zenza i-carcinogenic substance.
Impendulo eLawulayo malunga nokuba i-Splenda (Sucralose) ibangela umdlavuza
Kubalulekile, ukuqala ngesigqibo sekomiti yolawulo malunga nokuba i-Splenda ingabangela umdlavuza.
Ngokusekelwe kwizifundo ezingaphezu kwe-110 (i-physiochemical kunye ne-pharmacokinetic / i-toxicokinetic studies), kwibhabhi, kwizilwanyana nakubantu, iSplenda kucingelwa ukuba ikhuselekile. I-FDA ivume ukusetyenziswa kwe-sucralose ukuba isetyenziswe kwimakethi yabathengi ngaphandle kwemimiselo.
Ukongezelela, ukuphonononga i-metabolites (iimveliso eziphazamisayo ze-sucralose njengoko zixhaswa ngumzimba) zifunyanwe zingenayo i-carcinogenic potential. Ngokubanzi, i-sucralose ifumaneka ukuba ayinakho i-carcinogenicity okanye i-genotoxicity, kwimiqathango ephezulu kwii -vitro kunye nezifundo ze-vivo . Ucwaningo lwe-in vitro lubhekisela kulawo aqhutyelwa kwilebhu ngokuqhelekileyo kwisitya, ngoxa iinjongo ze-in vitro zivavanya indlela i-substance inxulumene ngayo emzimbeni wezilwanyana zasebhoratri okanye abantu.
Ngaba i-Splenda (Sucralose Caus Cancer? - The Studies
Sivile oko kuthethwa yi-FDA, kodwa makhe sithethe malunga nokuba zeziphi izifundo, oko bangathethiyo, nento engayifundwa ukuze wenze isisombululo sakho esifundekileyo malunga nokuba ngaba unqwenela ukuba kuquka iSplenda ekudleni kwakho.
Uninzi lwezifundo aluboniswanga naluphi na ukwanda komngcipheko womhlaza kunye neSpenda ngaphandle kwe-2016 isifundo saseNtaliyane. Kule sifundo ekhangele umphumo wokutshatyalaliswa kwamagundane e-swiss, kwafunyaniswa ukuba amagundane endoda aboniswe kwii-high dose ze sucralose zineengozi yokwanda kwe-leukemia. Uphononongo olulandelayo olwenziwa ngumenzi aluphumelelanga ukubonisa lo mbutho, kodwa yintoni okwenziweyo uvavanyo?
I- Splenda (i-sucralose) kunye nokuhlolwa kwe-leukemia kubhekise kwiigundane ezazinikwa ngokulandelelanisa kwizidalwa ezintathu ezahlukileyo eziqala kwi-utero (ngokukhawuleza) kwaye zaqhubeka kuyo yonke imihla yazo. Kwizilingo ezilingana nezilingo zomntu eziqhelekileyo kwakungekho mngcipheko we-leukemia. Kwakukho, kodwa, umbutho kwii-doses ezilingana nezihlandlo ezine ezicetyiswayo ukuba zithathwe ngabantu xa zisetyenziselwa ubomi babo.
Ukufunda okunje kunzima ukutolika. Ngokuqinisekileyo, abaninzi abantu abanakusebenzisa izihlandlo ezine eziphakanyisiweyo zokunyusa iintsuku zonke zobomi babo. Kodwa yeyiphi imali ekhuselekile? Ngokubanzi, kucingelwa ukuba akukho mkhawulo okhuselekileyo kwi-carcinogen. Oku kunjalo kuphela isifundo-nangona sikhulu ngokuthelekiswa nezinye izifundo.
Xa kuthelekiswa nemingcipheko emininzi ebomini bethu, ukuba oko kuthetha ukuthintela ingozi yomhlaza, mhlawumbi incinci nezinye izinto ezinobungozi esicacisa kuyo yonke imihla. Ngokomzekelo, kucingelwa ukuba i-home exposure ku- radon ibangela ukufa kwabantu abangama-27,000 emiphunga yemiphunga yamagciwane rhoqo ngonyaka (kubakho abantu abangaba ngu-40 000 abafikelelwa ngumhlaza wesibeleko) kodwa abaninzi abantu abazange bathathe ixesha lokuthenga itekiti yokuhlola i- dollar eyishumi ukuze bafumane ukuba ikhaya labo ingxaki.
I-Sucrose (i-Sucralose) neZifo eziBulisa umzimba
Ngaphandle komngcipheko womhlaza, i-sucralose ifumaneke ukuba neendlela ezimbalwa zokuxhalabisa kwindlela yokugaya. Ngamanye amazwi, "ayifuni" okanye ayisebenzi. Ekubeni eli nqaku lijongene nomngcipheko wesifo somhlaza, siya kubambelela kwiziphumo ezinokuthi zibe nefuthe ekwakheni umdlavuza-nokuba zikude.
I-Splenda (i-sucralose) ibonakala iyancipha inani leebhaktheriya "ezintle" emanzini. Sifunda ukuba ukufumana ibhaktheriya elaneleyo kumathambo kubaluleke kakhulu okanye kubaluleke ngaphezu kokuba ne-bacteria "embi" emanzini. Akuqinisekanga ukuba le nto ibalulekile okanye ukuba oku kuhambelana nokufumana enye-ukuba isiphumo se-risk factor for inflammatory disease. Sidinga ukucaca phambili ukuba into ethile into engengozini ayithethi ukuba yinto ebangela. Umzekelo, ubudala buyingxaki yeengcambu ezininzi kodwa asikho imbangela yomhlaza. Isifo sesibindi esisifo (IBD) siquka izimo ezifana nesifo sikaCrohn kunye nesifo sezilonda zesilonda.
Siyazi ukuba izifo zesibilini ezivuthayo ziphakamisa umngcipheko womhlaza wekoloni . Ukongeza, ezinye zonyango ze-IBD ziphakamisa umngcipheko womhlaza . Ukukwazi oku asikwazi ukuba sisigxina kwisigqibo sokuthi isisu singenza umhlaza (ngokugqithisa kwi-IBD ebeka phambili umntu kumdlavuza) kodwa kubalulekile ukubuza lo mbuzo.
I-Splenda Ingaba Yandisa Ukondla kunye nokuchaphazela ukunyanya
Mhlawumbi uqhelana nesifundo esasigxotha i-airwaves: i-soda equkethe i-sweeteners engenziwayo ingenokwandisa umngcipheko wokukhuluphala. Izifundo ezininzi ziye zakhangela izibilini zokubethisa ubunzima kwaye nangona kungekho xesha lokujongana nalo apha, uSplenda (sucralose) ufunyenwe ukwandisa ukondla ubuncinane kwisifundo esinye. Ekubeni ukunyamezela kuyinkalo enamandla yomdlavuza (phantse intloko ngoku ngokutshaya) kunye nesifo sikashukela (esoloko sihlobene nokukhuluphala) sisichengeni esizimeleyo somhlaza, esi sihloko esibalulekileyo kufuneka sijonge ngakumbi.
Ukufumana ukuba i-sucralose inokunyusa ukondla kunyanzeliswa ukuba i-compound isetyenziselwa ukuphepha iikhalori ezinxulumene noshukela. Ukukhathazeka okwenene, nangona kunjalo, ukuba umMerika oqhelekileyo udla ushukela ode kakhulu, kwaye ukukhuluphala sele kuye kwaba yintlupheko.
Splenda (Sucralose) kunye neHuat
Izifundo zokhuseleko zenzelwe ukujonga imiphumo nokuzinza kokutshatyalaliswa phantsi kweemeko eziqhelekileyo zokusetyenziswa. Abanye abaphengululi babuza umbuzo othi, "Kwenzeka ntoni ke, ukuba i-sucralose iyabonakala ekutshiseni, njengokupheka?" Kulo mqathango (kunye nokufudumala okulula) kukho inkxalabo eninzi. Ukupheka sucralose kumaqondo aphezulu avelisa izixhobo ezibizwa ngokuba yi-choropropanols ezinokuthi ziyingozi.
Impembelelo yezoLimo zeSplenda
Ekubeni i-sucralose ingena emanzini kwaye ikhona emanzini angaphantsi komhlaba, izazinzulu ziye zazama ukutadisha ntoni-ukuba nayiphi na umphumo-ezinokuthi zenzeke ngokwemvelo. Ngeli xesha asiqinisekanga.
Ngaphantsi kweSplenda (Sucralose) iMpilo kunye neCarcer
Ngexesha langoku, akukho ubungqina obuncinane bokuthi i-sucralose-esetyenzisiweyo kwiimali eziqhelekileyo kwaye ingashushutyi-inomdla wengozi yomhlaza. Ukulandela "yonke into ekumodareyithweni", umthetho ongekho u-Splenda omncinci mhlawumbi awufanelekile ukukhathazeka kwabo banqwenela ukudibanisa.
Kubalulekile ukuba uqaphele ukuba ngelixa abantu abaninzi bekhathazekile malunga nento esingaziyo ngamakha amnandi, mhlawumbi ezinye izingozi ezinobomi bethu ezinokuba zifaneleke ngakumbi ekugxilweni kwethu.
Imithombo:
Berry, C., Brusick,., Cohen, S., Hardisty, J., Grotz, V., noG. Williams. I-Sucralose engekho I-Carcinogenicity: Ukuphononongwa kweScientific and Regulatory Rationale. Isondlo kunye neK cancer . 2016. 68 (8): 1247-1261.
I-Cesare Maltoni Research Centre. I-Sucralose ilawulwa kwi-Feed, iqalisa ngokuPhila ngokuPhila, ikhupha i-Hematopoietic i-Neoplasias kwiMicekazi yaseSwitzerland. I-International Journal ye-Occupational Health and Environmental Health . 2016. 22 (1): 7-17.
Grotz, V., kunye nami Munro. Ingqwalaselo yoKhuseleko lwe-Sucralose. I-Toxicology yoLawulo kunye ne-Pharmacology . 2009. 55 (1): 1-5.
Li, R., Zheng, J., Jiang, M., Liu, Y., Qin, X., kunye no-X. Wang. Ukunyuka kwama-Digestive Proteases kunye nokunciphisa i-β-Glucuronidase kwiiNtshontsho zeeRats eziphathwe nge-Sucralose ne-Saccharin-Olunye ubungqina obunzima bokuthi ezi ziKhemikhali zeDeetary ziba zizinto ezibalulekileyo ezibangelwa zizifo ezithintekayo. Izifo ezithintekayo . 2016. 22 (8): E29-30.
Schiffman, S., noK. Rother. I-Sucralose, i-Organochlorine Sweetener ye-Synthetic: Ubume be-Biological Issues. Umbhalo weTyxicology kunye neMpilo yendalo. Icandelo B, IziPhononongo eziPhambili . 2013. 16 (7): 399-451.
Soffritti, M., Padovani, M., Tibaldi, E., Falcioni, L., uManservisi, F., noFelpoggi. Iimpembelelo zeCarcinogenic Aspartame: Isidingo Esiphuthumayo sokuVavanywa kwakhona koLawulo. Umbhalo waseMelika weMveliso yamayeza . 2014. 57 (4): 383-97.
Wang, Q., Lin, Y., Zhang, L. et al. I-Sucralose ikhuthaza ukuThengiswa kokutya nge-NPY kunye ne-Neuronal Fasting Response. Cell Metabolism . 2016. 24 (1): 75-90.