Umdlavuza wesifuba unxulumene ngokuqinileyo nokutya kunye nendlela yokuziphatha. Bobabini ukukhuluphala kunye nesifo sikashukela nabo banxulumene nomhlaza ngenxa yemiphumo yokukhuthaza ukukhuphula i-insulin. Ngoko ukungenelela okuya kunceda ukugcina i-glucose yegazi kwindawo ephilileyo kunokunceda ukuba ungathinteli kuphela isifo sikashukela sohlobo lwesibini, kodwa nesifo somhlaza wesifuba.
Ukuphazamiseka kweziqhelo eziqhelekileyo ze- circadian kuye kwadibaniswa nomhlaza wesisu.
Abasebenzi bokuhamba ebusuku baye bafunyanwa kwizifundo ezininzi ukuba babe nomngcipheko omkhulu kunabo abaneshedyuli eqhelekileyo, ezihambelana nomjikelezo okhanyayo / omnyama.
Ngoko ke, ngaphezu kokutya okunempilo, utshintsho olulula-oluphela ekudleni ekuqaleni kwantambama-lunokuphucula kokubili i-glucose metabolism kunye nokulungelelaniswa kwewashi, okukhokelela ekunciphiseni ingozi yomhlaza wesifuba.
Sisoloko sincoma ixesha lokuzila lokulala-ixesha eliphakathi kokuhlwada ngokuhlwa kunye nesidlo sasekuseni ekuseni-ukunyusa ukuphulukisa nokulungisa. Isigaba sezintlu siqala xa kugcinwa ukugaya, kunye nokukhutshwa kwe-detoxification kunye nokulungiswa kwenzeka. Uphando luye lwaqokelela ukuba iikholori ezidlulileyo ngokuhlwa kwaye ubude bexesha lokuzila ebusuku (i-catabolic phase) lichaphazela ama-biomarker anxulumene nomhlaza webele.
Ixesha lokuzila ukutya ebusuku, ukuvutha, kunye nokuLawula i-Glycemic
Idatha kwi-NHANES (i-National Health and Nutrition Examination Survey) idatha yabasetyhini aba-2,650 bafumene ukuba abo badla inxalenye enkulu yeekhalori zabo zemihla ngemihla (ngo-5: 00 ntambama - 12: 00 ekuseni) banamazinga aphezulu ase C- protein (CRP) , uphawu lokuvuvukala.
Ukunyuka kwama-10 ekhulwini kwinqanaba leekhalori ezidliwayo kusihlwa, kwakukho ukwanda kweepesenti ezi-3 kwi-CRP. Abasetyhini ababenexesha elide lokuzila ukutya babenamazinga angaphantsi kwe-CRP (i-8% yehla yeyure nganye eyongezelelweyo), kodwa oku kwakuyinyaniso kubafazi ababesela ngaphantsi kwama-30 ekhulwini lamathole abo ngokuhlwa.
Isithuba esipheleleyo kwisigaba se-catabolic kunye nokutshintshwa kokutya kokudlulileyo kwimihla kunokunceda ukugcina ukuvuvukala.
Olunye uphando lusetshenziswe kwi-NHANES idatha ukuxela ixesha lokuzila ngokukhawuleza kubaphathi be-glycemic control. Abasetyhini abavakalisa ukutya ngokukhawuleza ubusuku bonke basebenzisa iikhalori ezimbalwa, iikhalori ezidliwa emva kwe-10: 00 ntambama, kunye nenani elincinci lokutya ngokutya kunye nokutya okutyhutyha nsuku zonke. Ieyure ezongezelelweyo ezintathu zexesha lokuzila ebusuku zidibene ne-4% yeepesenti (emva kokutya) i-blood glucose, kunye neepesenti ezingama-19 zingaphantsi kweHbA1c .
Ezi zifundo azizange zijongane nomhlaza webele. Kunoko, babheka ama-biomarkers anxulumene nobungozi. Olunye uphando olubalulekileyo luqokelelwa kwedatha yokutya kubasetyhini kunye nomhlaza wesifuba ukuze kuqinisekiswe ukuba kukho ukudibanisa phakathi kwexesha lokuzila ebusuku kunye nokuphindaphinda kwesi sifo.
Ixesha lokuzila ukutya ngabasetyhini abane-Cancer Breast
Kule sifundo, idatha yokutya iqokelelwe kubafazi abangama-2413 benomdlavuza wesibeleko, umnyaka omnye kunye neminyaka emine. Kuthetha ukuba ixesha lokuzila lalingama-12.5 iiyure ngobusuku, kwaye abathathi-nxaxheba bahlukana phakathi kwabo bazila ukudla ngaphaya kweeyure ezingama-13 okanye abo bazila iiyure ezili-13 okanye ngaphezulu. Ukuzila ukutya ngaphantsi kwama-13 iiyure kwakudibene nokunyuka kweepesenti ezingama-36 kwi-breast cancer emva kokulandelwa kweminyaka engama-7.
Kwakukho nokunciphisa kwi-HbA1c ngokukhawuleza ngokuzila ukudla ebusuku; Ukwanda kweeyure ezingama-2 kwixesha lokuzila lidibene ne-0.37 yezantsi HbA1c. Olunye uthabatha olufunyanisayo kulolu cwaningo kukuba abafazi ababenokuzila ukutya ngobusuku obude babela inani elikhulu leeyure. Ukwandisa ixesha lokuzila ngokuhlwa kubonakala kukuguquka kwendlela yokuphila kunye nemiphumo ebalulekileyo yokukhusela umdlavuza webele.
Ixesha elingakumbi kwiSigaba seCatabolic: Imoya yokuPhilisa kunye nokuPhepha
Emva kokutya, kukho izigaba ezibini ze-metabolism: ngexesha lesigaba se-anabolic, i-blood glucose isuka, kwaye enye isetyenziselwa amandla kwaye enye yayo igcinwa njenge-glycogen.
Emva kwexesha, i-glucose yegazi ibuyele kwisiseko; ngoko, ngexesha lesigaba, umzimba uphula i-glycogen yokugcina amandla. Xa i-glycogen igcina iphantsi, umzimba uqala ukusebenzisa amaninzi e-fatty acids. Ngethuba lesigaba esandisiweyo (ixesha lokuzila ukudla), umzimba uthatha ukulungiswa nokususwa kwamacandelo andala kunye nabonakalisiweyo, kunye nomzimba ukwakha ukunyanzeliswa kwengcinezelo.
Ukuzila ixesha elide (iintsuku eziliqela) kuye kwafunyanwa ukunceda ukunciphisa umsebenzi we-insulin kunye ne-IGF-1 yokuguqula indlela, ukunciphisa ukuvuvukala, ukunciphisa uxinzelelo lwegazi, nokuphucula ukuveliseka kwe-insulin. Kubonakala sengathi ukutya okuqhelekileyo, okude kwimizuzu yokulala kunokuvelisa ezinye zezibonelelo ezifanayo.
Ukutya ixesha kunye neRhythm Circadian
Iwashi lenkosi kwi- hypothalamus ibonisa isigqi esekelwe kumbane okhanyayo / omnyama, kwaye kukho iiwashi zepheripher in a malungu amaninzi. I-clock ye-peripheral kwisibindi, umzekelo, ivuselelwe xa sidla. Ingcamango kukuba xa sidla ngokuhlwa ebusuku, ezinye iwashi zepheripha ziphuma ngaphandle kokulungelelanisa newashi le-master. Ukugqiba ukutya kwethu kwangoko kusasa kukutya okunye ukuvumelanisa neziqulatho zethu ze-circadian, ezikhokelela ekulungelelaneni kweeyure zethu ze-circadian kunye nokulala okungcono.
Ubuninzi be-Insulin bunesigqi salo; liphezulu ekuseni kwaye liphantsi ngokuhlwa, ngoko kuqikelele ukuphela kokutya kwindi window ngaphambili kunokuba kuya kuba luncedo kwimpilo yethu. Le ngcamango yokuqala ngophando ixhasa le nto, njengoko i-CRP yayiphezulu kwabasetyhini abadla iikhalori ezininzi ngokuhlwa. Kufuneka kube nini ixesha lakho lokulala ngokukhawuleza? Ngokusekelwe kuphando, iiyure ezingama-13 ziqala ukuqala, kwaye ixesha elide linokuthi libe ngcono.
> Imithombo:
> Kamdar BB, Tergas AI, Mateen FJ, et al. Umsebenzi wokuguquka ebusuku kunye nomngcipheko wesifo somhlaza wesifuba: ukuphononongwa ngokuchanekileyo kunye nokuhlaziywa kwemeta. I-Cancer Res Treat Treat 2013, 138: 291-301.
> Wang F, Yeung KL, Chan WC, et al. Uhlalutyo lwe-meta kwi-response-response response phakathi kobusuku bokusebenza kunye nomngcipheko wesifo somhlaza. Ann Oncol 2013, 24: 2724-2732.
> Marinac CR, Sears DD, Natarajan L, et al. Ukuphindaphinda kunye nexesha le-Circadian Ukutya okuMeyi kungenza i-Biomarkers of Inflammation kunye neNtshutshiso ye-Insulin ejongene neengozi zeCatter Cancer. PLoS One 2015, 10: e0136240.
> Marinac CR, Natarajan L, Sears DD, et al. Ukuzila ukudla ngokukhawuleza ebusuku kunye neengozi zesifo somhlaza webele: iziphumo ezivela kwi-NHANES (2009-2010). I-Cancer Epidemiol Biomarkers Ngo-2015, 24: 783-789.
> Marinac CR, uNelson SH, uBreen CI, et al. Ukuzila ukutya ngokukhawuleza ebusuku kunye neNtsholongwane yeCarcer Bregnosis. JAMA Oncol 2016.