Nangona i-melatonin i-hormone eyenza ingqondo ivelise ngokwemvelo, unokukwazi ukuba bhetele njenge-rem-counter-counter counter for the jet lag and sleep disturbances. Ingqungquthela yengqondo yepineal igcina i-melatonin kwimizuzu engama-24. Kwakhona kuveliswa kwesikhumba, i-retina yeso kunye nomnatha wethambo.
Kwimvelo, ukuveliswa kwe-melatonin kwiindawo zokulala ebusuku, kwaye kuvinjelwe ukukhanya kwemini.
Xa ubumnyama buya kwanda amanqanaba e-melatonin, ukuzisa ukunyaniseka nokuzola-kwaye sinethemba lokuba, ulala. Ezinye izinto kunye nama-hormone afana ne-serotonin nazo zibalulekile, nangona kunjalo, ekulawuleni umjikelezo womzimba wokulala .
Ukulala, iMelatonin kunye neCarcer
Izifundo ezibonisa ukudibanisa phakathi kokulala kakubi, amanqanaba aphantsi e-melatonin kunye nomhlaza uye wakhupha umdla omkhulu. Umsebenzi wokutshintshwa ebusuku udibene nokukhathala nokungazinzi, amanqanaba aphantsi e-melatonin egazini, kunye nezifo ezininzi ezahlukahlukeneyo kuquka nesifo senhliziyo, isifo se-metabolic syndrome-kunye neentsholongwane zeentlobo ezahlukeneyo.
Umsebenzi weShift kunye neKarcer Risk
Zonke ezi ziphumo kubasebenzi be-shift ziye zabangela ezinye izazinzulu ukuba zibuze ukuba i-melatonin inokunceda njani ukukhusela abantu ezi zifo. Uphononongo olulodwa lwaseCanada kumsebenzi wesigxina wesilisa lufumene ukuba umsebenzi webusuku unxulumene neentlobo ezininzi zeentlobo ezahlukeneyo zomdlavuza, kuquka ne-Hodgkin lymphoma .
Ezi ntlobo zophando zikhangele ukubona ukuba into eqhelekileyo ihambelana nantoni na into-"inqamlezo," okanye kuthiwa yi-epidemiological in nature.
Iingxelo ezivela kwizifundo ezifanayo zibonakala zibonisa inxaxheba ekwenzeni i-melatonin kunye nokuphazamiseka kokulala kwisifo somhlaza wesifuba kwakhona: abafazi abasebenza ubusuku bo-19 ukuya kuma-51 ekhulwini banomngcipheko wesifo somhlaza webele. Ngokuphathelele umdlavuza we-prostate , uphando oluthile lufumene ukuba amadoda anomdlavuza weprotate anezinga elincinci le-melatonin xa kuthelekiswa namadoda anesifo somhlaza kodwa esingabaphazamisa ukulala, i-benign prostatic hyperplasia.
Akukho nanye kwezi zifundo zihlobo olungabonisa imbangela nefuthe, nangona kunjalo. Iziphumo zikunceda ukufumana izifundo ezongezelelweyo, kodwa abaxhasi ukusetyenziswa kwe-melatonin ukukhusela umhlaza.
Iinkcukacha zezilwanyana kunye neLebhu
Izifundo zeLebhu yezilwanyana zibonisa ukuba i-melatonin yintsholongwane ene-antioxidant evuselela ezinye iinjongo ze-immune system, kodwa ayaziwa ukuba le mpembelelo ivela kubantu. I-Melatonin ibonakala ithintela ezinye iiseli zomhlaza ukuba zikhule xa zisetyenziswe ngokuthe ngqo kwiiseli kwiibhodi zelabhoratri kunye nezifundo zezilwanyana-esi sibonelo sibonwe ngumhlaza wesibeleko kunye ne-melanoma.
Uphando lwabantu, nangona kunjalo, alucebiseli nayiphi na impembelelo.
Ngokusekelwe kwiinkcukacha ze-in vitro, ezinye izazinzulu ziye zaqikelela ukuba ukuvuselelwa kwe-immune, ukuba ikhona kwi-vivo, ingabi yinto entle kuzo zonke iimeko. Ngokomzekelo, uhlobo olungalunganga lokuvuselela umzimba kwizigulane ezine-leukemia okanye i-lymphoma kunokuthi lube yimpembelelo, kuba la mayeza aquka ukungcola kwamaseli omzimba kwi-lymph system, umongo wegazi kunye negazi.
I-Melatonin kwimimodeli yokuhlola ibonise iimpawu ezithile zokulwa nomhlaza, kwaye ukukhuthazwa kwenkqubo yokuzivikela komzimba kuthathwa ukuba kubandakanyeke. Ucwaningo olwenziwa nguMiller lucebise ukuba i-melatonin ithatha inxaxheba ekusebenziseni i-lymphocytes kunye ne-monocytes / macrophages-iintlobo ezahlukeneyo zeeseli zegazi ezimhlophe.
I-lymphomas yile khansela ephuma kwi-lymphocytes.
Kwi-vitro, i-melatonin ibonakala ithatha isenzo sokwandisa umenzi wendalo we-T-cell , ivuselela izibonakaliso ezithile zeeselithi ezibizwa ngokuba yi-cytokines; inokukhusela ezinye iisanduli zeseli zegazi ezisuka kwisiphumo setyhefu ye-chemotherapy kunye ne-radiotherapy , ngokutsho kovavanyo luka-2001 lwamaMaestroni.
Kwakhona, awaziwa ukuba i-melatonin ingaba nefuthe kule vivo, kwizigulane zangempela.
IMelatonin kwiCreatcer Treatment
Kuncinci kakhulu owaziwa nge melatonin xa isetyenziswe kubantu abanomdlavuza. Elinye iqela lezenzululwazi lihlaziye ngokucwangcisekileyo imiphumo ye-melatonin xa inikezwe kunye ne-chemotherapy, i-radiotherapy, ukunakekelwa kokunyamekela kunye nokunyamekela ngokunyamezela kwizigulane ezinesifo se-metastatic esisisigxina - kungekhona i-leukemia okanye i-lymphoma.
Kule sifundo, i-melatonin yayingenakunxulumaniswa nokutywala okanye ukunciphisa unyango olululo, kwaye kwakubonakala kunceda ezinye iziphumo zecandelo le-chemotherapy.
I-Melatonin kwiGulana yeCarcer Cancer
Ngaphantsi kwaziwa xa ifika kwi-melatonin kubantu abaneengcingo zegazi ezifana ne-leukemia kunye ne-lymphoma . Isikhokelo seNational Cancer Network (NCCN) sangoku kwi-non-Hodgkin lymphomas, uhlobo oluqhelekileyo lwe-lymphoma, alubandakanyi iziphakamiso kwi-melatonin.
Ubuninzi bophando olushicilelwe njengamanje kwi-melatonin ekho naluphi na oluhlobene ne-lymphoma lubonakala luvela kwi-in vitro nedatha yezilwanyana, kungekhona iilingo zeclini.
Soloko uthetha nodokotela wakho malunga nokuthatha nayiphi na isongezelelo, njengoko izongezo zingaba nemiphumo emibi kunye nokusebenzisana kwezidakamizwa.
ILizwi elivela:
I-Melatonin isetyenziswe ngokukhuselekileyo njengokuba uncedo lwabuthongo lwabaninzi, kwaye inendima ebalulekileyo ekwenzeni unyango lweentlobo zokulala.
I-Melatonin ngumkhiqizo wemvelo, kodwa iimveliso zendalo zingasenayo imiphumo emibi kunye nokusebenzisana okungalindelekanga. I-Melatonin inokusebenzisana kunye neendidi ezahlukeneyo zamachiza, kuquka i-sedatives, i-anti-depressants, imithi ye-hormonal kunye nabanye.
Thetha ugqirha wakho malunga nokusetyenziswa kwe-melatonin okanye nayiphi na enye inkxaso-ngakumbi xa uphathwe ngumhlaza okanye nasiphi na isifo esingapheliyo.
Imithombo
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I-SD ye-Paredes, uRancan L, uKireev R, et al. I-Melatonin Ukuchasene kwiNqanaba lokuTyhulwa kweNgcaciso kunye neApoptotic Response Secondary kuya kwi-Ischemic Brain Injury Ekhutshwe yi-Artery Cerebral Artery Blockade kwiRats Aging. BioResearch Ufikelelo oluvulelekileyo . 2015; 4 (1): 407-416.
Izikhokelo ze-NCCN kwi-Non-Hodgkin Lymphoma. Version 1.2016. Finyelela ngoFebruwari 2016.