I-Huma isetyenziselwa ukuphatha izifo zika-Crohn kunye ne-Rheumatoid Arthritis.
U-Humira (adalimumab) ngumntu onomntu ongu-monoclonal antibody. Isebenza ngokuthintela i- tumor necrosis i-alpha (TNF-alpha) , i- cytokine edlala indima kwinkqubo yokuvuvukala.
Abantu abanezifo zesibindi sokuvuvukala (IBD) banexabiso elingaqhelekanga lika-TNF-alpha, kwaye kucingelwa ukuba oku kudlala indima kwinkqubo yesifo. U-Humira uyeka i-TNF-alpha ekubeni isetyenziswe ngumzimba.
Humira uthathwa njani?
U-Humira ufika ngendlela yejojo kwaye kufuneka agcinwe efrijini. Injola inikezelwa phantsi kwesikhumba (ngaphantsi) mhlawumbi ekhaya okanye kwiofisi yegqirha. U-Humira unikezelwa kanye emva kweveki okanye ngezinye ngeveki. Umyinge uvame ukuba ngama-40 milligrams. I-Humira akufanele ijojowe kwindawo enye kwindawo emzimbeni amaxesha amabini ngokulandelana. Izigulane zifanele zijikeleze apho zinika ijojo - ngokuqhelekileyo isisu okanye phambi kwentsanga. Ugqirha uyalela uya kunika nayiphi na imiyalelo ekhethekileyo kwaye uchaze indlela yokulawula umjovo ekhaya, ukuba kuyimfuneko. Ukuba unemibuzo malunga nendlela yokunika injini, ungabiza (800) 4HUMIRA (448-6472).
Kutheni Kuthiwa?
I-Humira inokumiselwa kwisifo se-Crohn okanye i-ulcerative colitis, iifom ezimbini ezibalulekileyo ze-IBD. Inikwe ngokubanzi emva kokuba ezinye iziyobisi ziye zazama kwaye azisebenzi okanye ukuba iimpawu ze-IBD zinzima gqitha.
I-Humira ivunyiwe ukuba isebenzise abadala kunye nabantwana abangaphezu kweminyaka engama-6.
I-Humira inganciphisa impawu eziqhelekileyo ze-IBD (intlungu, ukukhathala kunye nesifo sohudo) okanye kunokususa ukuxolelwa. Kwilingo elilodwa lwezonyango ezinezigulane ezineesifo sikaCrohn, iipesenti ezingama-40 ukuya kuma-47 ezigulane ezaphathwa ngo-Humira ziye zalahlwa emva kweeyure ezingama-26 zonyango.
Emva kweeveki ezingama-56, malunga ne-40% yezigulane zisenokuxolelwa.
Ngubani Akufanele Awuthathe?
Tshela ugqirha wakho ukuba ulungiselelwe nawuphi na uhlobo lotyando okanye ufumane ukugonywa kutshanje. Kananjalo ugqirha ugqirha wakho ukuba uyazi okanye unayo nayiphi na le miqathango ilandelayo:
- Ukuphendulwa kwamanzi kwiyiphi na imithi
- I-Cancer (i-lymphoma)
- Njengamanje ukhulelwe
- Usulelo lwefungal
- Ukumelwa yintliziyo
- I-hepatitis B
- Lupus
- Isifo sokugubhuka
- Izifo ezifayo
- Ukuxhamla
- Isifo sofuba
Ziziphi iimpembelelo ezingekho kwiHumira?
Umphumo oqhelekileyo wesigxina se-Humira intlungu, ukucaphukisa, ukuvuvukala okanye ukubetha kwisayithi yejojo. Ezinye iziphumo eziqhelekileyo ziquka intloko yesifo, ukukhawuleza kunye nesiphithiphithi. Kukho umngcipheko wokuhlawula usulelo olunzulu xa uthatha uHuma, nangona kungenakwenzeka. Tshela ugqirha wakho ukuba uhlakulele nayiphi na impawu okanye iimpawu zentsholongwane okanye ukuba nayiphina imiphumo emibi ingxaki okanye ungahambi.
Ziziphi Iimpawu Zokuba Unokusebenzisana?
Akukhuthazwa ukuba iHuma ithathwe ngamanye ama-agent ekhusela i-TNF, njengeKineret (anakinra), iigciwane eziphilayo okanye i-methotrexate. Tshela ugqirha wakho ukuba uthatha naziphi na iziyobisi ezithintela umzimba wokuzivikela, njenge-cyclosporine.
Ngaba kukho ukubandakanyeka kokutya?
Akukho ukusebenzisana kokutya okuyaziwayo.
Ngaba I-Huma Safe ngexesha Lokhulelwa?
I-FDA ifake uHuma njengesiqhamo seB B. Izifundo kwizilwanyana azibonisi ubungqina bengozi kumntwana; Nangona kunjalo, akukho zifundo ezifanelekileyo, ezilawulwa kakuhle kwabasetyhini abakhulelweyo. I-Huma kufuneka isetyenziswe kuphela kwabasetyhini abakhulelweyo xa befuna ngokucacileyo. Yazisa ukuba ugqirha ukuba uyakhulelwa ngelixa uthabatha u-Humira.
Olunye uphando oluncinane lubonisa ukuba uHumira uwela i-placenta kwaye angene egazini le-fetus ngethuba lokugqibela lokukhulelwa. I-Humira ingafunyanwa kwigazi legazi elifikelela kwiinyanga ezi-3 emva kokuzalwa. Kunconywa ukuba iintsana ezizalwe koomama ezithatha u-Humira zihlolwe ngokusondeleyo ukusuleleka kwiinyanga ezi-6 zokuqala, kwaye azifumani naluphi na ugonyamelo lwegciwane oluphilayo.
Ayaziwa ukuba iHuma iya kudlula ubisi lwebele; Nangona kunjalo, ezinye izinto ezifanayo ziboniswe ukuba zidlule ubisi lwebele. Ukunceliswa kwesisu ngexesha lokuthatha iHuma akucebisi.
Yintoni endiyenzayo xa ndilahleka iDose?
Ukuba ulahlekelwa umthamo, thatha ngokukhawuleza ukuba ukhumbule. Emva koko thabatha umthamo wakho olandelayo ngexesha elihleliweyo. Musa ukuphindaphinda kabini okanye uthathe idosi enye ngexesha.
Imithombo:
Abbott Laboratories. "Huma Guide Guide." Humira.com NgoMatshi 2011. 17 Matshi 2011.
Colombel JF, uSandborn WJ, Rutgeerts P, Enns R, Hanauer SB, Panaccione R, Schreiber S, Byczkowski D, Li J, Kent JD, Pollack PF. "I-Adalimumab yokugcinwa kwempendulo yekliniki kunye nokuxolelwa kwizigulane ezineesifo sikaCrohn: ityala le-CHARM." Gastroenterology 2007 Jan; 132: 52-65. 17 Apreli 2011.
I-Mahadevan U. "Amanqanaba eAdalimumab afunyenwe kwiCord Igazi kunye neentsana eziboniswe eUtero (Abstract # 277)" Iveki yeSifo seNtsholongwane ka-2011. 26 Feb 2012.
PDR yezeMpilo. "Humira." Thomson Healthcare 2008. 17 Apreli 2011.