Iinjongo ezininzi ze-IBD Iithagethi ze-TNF zokuphatha ukuvutha
I-tumor necrosis factor (TNF) ngumhlobo weprotheni yomthunywa obizwa ngokuba yi-cytokine eveliswa ngamaseli egazi ezimhlophe . I-TNF ibalulekile emzimbeni kuba inceda ekulawuleni indlela yokuphendula umzimba wokuzikhusela kumntu wasemzini, ngokukodwa kwisisu esinomhlaza. Ikhuthaza ukuvuvukala, ivelisa ezinye iiseli ezisetyenziselwa impendulo yokuvuvukala, kwaye zinokunceda iiseli ziphilise.
I-TNF ngamanye amaxesha ibizwa ngokuba yi-tumor necrosis-alpha-alpha.
Kutheni i-TNF-alpha ibalulekile kwi-IBD
I-TNF yimixholo ebalulekileyo ekuphatheni izifo zesibindi sokuvuvukala (IBD). I-TNF ifumaneka kwixabiso eliphezulu kubantu abanesifo sikaCrohn kunabantu abangenayo isifo sikaCrohn. I-TNF ifunyenwe kwakhona, kwizinga elincinci, kwisihlalo sabantu abanesifo sokulonda kwesilonda. Ngenxa yalo mbutho, kucingelwa ukuba i-TNF idlala indima ekuphuhliseni kunye / okanye ngokuqhubeka nesifo sika-Crohn kunye nesifo se-ulcerative colitis. Yingakho iziyobisi ezibizwa ngokuba yi-biologics ziye zaphuhliswa ukuphatha i-IBD kunye nezinye izinto ezivuthayo. Ukujoliswa kwe-TNF kubonisa inzuzo kwezinye izigulane ekunciphiseni iimpawu ze-IBD kunye nokuphilisa ukuvuvukala kwindlela yamathumbu.
I-calectectin yeFecal kunye ne-lactoferrin ziimakishi ezimbini ezisetyenziselwa ukuvavanya ukuvutha kwamanje kubantu abane-IBD. Ezi proteins ezimbini zingalinganiswa ngokuvavanya isitulo.
Kuye kwafumanisa ukuba xa kukho ezininzi zezi proteins kwisitulo, kukho ukugqabhuka okukhulu emathunjini abantu abane-IBD. Xa ixabiso lala ma-protein liphantsi kwi-stool, kukho ukuphulukiswa okwenzekayo emathunjini. I-calprotectin ephantsi ye-fecal kunye ne-lactoferrin ingathetha ukuba unyango lusebenza kwaye isigulane sisondela, okanye siyaxolelwa.
Izifundo ziye zabonisa ukuba ama-fecal calprotectin kunye namazinga e-lactoferrin aphantsi kwizigulane ezithathe izidakamizwa ezichasene ne-TNF.
Iintlobo ezahlukeneyo ze-TNF
Izifundo ze-Genetic zibonise ukuba kukho iintlobo ezahlukeneyo ze-TNF, kwaye i-TNF imele ithathwa ngokuba yi "superfamily". Iindidi ezahlukahlukeneyo ze-TNF ziye zadibana nezifo ezizimeleyo, i-cancer, nesifo sikashukela. Ukufumana iintlobo ze-TNF-ezinxulumene neemeko ezithile kunokunceda ekuphuhliseni iziyobisi ukuphatha ezo zifo.
Bonke abantu abane-IBD abaphenduli kwiziyobisi ezifanayo ngendlela efanayo. Oku kunokwenzeka, kwaye ngoku kucatshangwa ukuba yimeko yinkwenkwezi, ukuba kukho ezininzi ze-IBD. I-TNF inokudlala indima kule nanjalo, kuba abanye abantu abane-IBD baphendule kakuhle kwiiyobisi ze-blocker ze-TNF, ngelixa abanye abantu bengenzi. I-genotype yesigulane se-TNF yesigulane inokuthi idibaniswe nempendulo enkulu okanye encinci kwisicatshulwa esithile se-TNF. Le yindawo ephuhlisayo yophando, kwaye kusekho okunye okumele kuqondwe malunga ne-TNF ngaphambi kokuba isetyenziswe ekunyamekelweni kwezigulane.
I-TNF-alpha KwiCaron Cancer
I-TNF inokuba nenendima ebalulekileyo yokuvelisa umdlavuza wekolon kunye nezinye i-cancer zesisu. Uphando malunga nale mphumela ye-TNF ayingenakulinganiswa, kodwa inokubonelela ngeenkcukacha ezithile phakathi kokuqhathaniswa kwezilonda zesilonda kunye nomhlaza wekoloni.
I-anti-TNF-alpha Medication
Olunye unyango lwezonyango kwi-Crohn's disease lubandakanya ukujoliswa kwiprotheni ye-TNF kwaye iyayibopha. Xa iprotheni iboshwe, ayikwazi ukuvelisa ukuvuvukala. Ezinye izidakamizwa ze-TNF zi- Remicade (infliximab), i- Humira (adalimumab), i- Cimzia (certolizumab pegol), i- Enbrel (etanercept) kunye ne-Simponi (golimumab).
Inqaku esuka
Kukho okungaqondakaliyo malunga ne-TNF kunye nolwalamano lwalo kunye nezimo ezivuthayo ezifana ne-IBD. Nangona kunjalo, izidakamizwa ezininzi ze-TNF zenzelwe ukusetyenziswa kubantu abane-IBD, kwaye zinokuphucula iziphumo zezifundo zezi zifo.
> Imithombo:
> Sipponen T, Savilahti E, Kärkkäinen P, et al. "I-Fecal calprotectin, i-lactoferrin, kunye nesifo se-endoscopic ekujongeni unyango lwe-TNF-alpha kwisifo sikaCrohn." I-Inflamm Bowel Dis. 14: 1392-1398.
> Subramaniam K, uRichardson A, uDodd J, et al. "Ukucwangciswa kwangaphambili kwe-colectomy kunye nokugcinwa kwexesha elide lokuxoshwa kwizilonda zezilonda zesifo sezilonda ziphathwa ngokusebenzisa i-anti-tumor necrosis yonyango." I-Intern Med J. ngoMeyi ngoMeyi; 44: 464-470. i-doi: 10.1111 / imj.12397.
> Taylor KD, Plevy SE, Yang H, et al. "Iprogram ye-ANCA kunye noLTA ubudlelwane be haplotype kwizimpendulo zonyango kwi-anti-TNF yonyango lwonyango kwi-Crohn's disease." Gastroenterology . 2001 ngoMeyi; 120: 1347-1355.
> Yang JP, Hyun MH, Yoon JM, et al. "Umbutho phakathi kwe-TNF-α-308 G / A i-polymorphism ye-gene kunye nomngcipheko wesifo somhlaza: ukuhlaziywa okucwangcisiweyo kunye nokuhlaziywa kwemeta." ICytokine . 2014 Dec; 70: 104-114. i-doi: 10.1016 / j.cyto.2014.07.005.