Ngaba ukutshintshwa kwamaFecal kube yonyango lwexesha elizayo kwi-IBD?
I-Fecal bacteriotherapy (FB) okanye i-fecal microbiota transplantation (FMT) luhlobo lonyango oluye lwasetyenziselwa iminyaka emininzi, kodwa ngoku luqala ukujongwa kwisicelo sayo kwisifo soxhamlo (IBD) . I-FB ngamanye amaxesha isetyenziselwa ukuphatha iintsholongwane eziqhelekileyo ngeClostridium difficile (okanye iC difficile ), nangona oku akuqhelekanga.
ILizwi Eliqilileyo Lokulumkisa
Ukufakelwa kweefecal akufanele kwenziwe kwindlu , nangemva kokufunda imiyalelo okanye incwadi okanye ukubukela ividiyo yendlela yokwenza ngayo.
Akusiyo "indlela" yokwenza oko okuyinxalenye nzima. Inxalenye esacatshangelwayo yintoni eyenza umniki-mhle kunye nendlela abaxhasi abahlala ngayo ama-bacterium aya kusebenzisana kwaye atshintshe ibhakteria yomgudu wommkeli. Izigulane ziye zafa emva kokusebenzisa "ukuzenzela" ukuguquka kwamafecal. Abanye baye bafumana iziphumo ezingalindelekanga ezifana nezifo ezitsha zesilonda okanye ukufumana ubunzima. Olu unyango lusacatshulwa kubantu abane-IBD kwaye akuzange kubekho into ekufuneka yenziwe ekhaya.
I-Fecal Bacteriotherapy I- C Inzima
Amathumbu amakhulu ahlawulela iintlobo ezahlukeneyo zeebhaktheriya. Ukubunjwa okanye inani leentlobo ezahlukeneyo zeebhaktheriya zinokutshintshwa zizifo okanye ngamachiza. Usulelo lwe- C oluyingozi luya kwenzeka xa isityalo se-bacterial kwisitembu esikhulu sitshintshile (ngokuqhelekileyo ngama-antibiotics), okuvumela i- C difficile ukuba yanda kwaye ivelise i-toxins, engabangela ukonakalisa ukonakala komzimba kunye nohudo.
Unyango oluqhelekileyo lokusuleleka ngo- C oluyingozi luyikhosi ye-10 ukuya kwe-14 yee-antibiotics ezichasene no-C . Ngamanye amaxesha, i- C enzima ye- colitis ingakwazi ukubuyela emva kokuba unyango luphelile. Kungenxa yale meko yokukhankanya ukuba i-FB iye yakhanga umdla.
I-FB yonyango olusakhulayo olungasetyenziswanga okanye luqhutywe ngokubanzi, kodwa luye lwazama kwabanye abantu abanokusuleleka kwizifo eziphefumulayo zeC .
Inkqubo iqala ngesihlobo esiseduze nesigulane esilungele ukuqokelela i-stool kwiintsuku ezimbalwa kwaye sizinikele. I-fecal umbuzo ivavanyelwe nantoni na engayibonakalisa ingozi-njengesifo, ibhaktheriya yangaphandle okanye iipasasites . Emva kokuba isitulo sinqunywe ukuba sikhusele ukufakelwa, singasetyenziselwa iFB.
Indlela iFecal Bacteriotherapy eyenziwa ngayo
Izinto eziphathekayo zingaphinde zitshintshelwe kwisigulane nge- enema , i- colonoscopy okanye i- nasogastric (NG) tube . Ukuba kunikwe i-enema, umba wefecal uza kuxutywa kunye ne-liquid, efana ne-saline, kwaye inikezwe ngugqirha, okanye ekhaya ngelungu lentsapho okanye isigulane ngokwakhe. I-enema kuphela ifaka phezulu kude kwikholoni, ngoko ukulawula ukutshintshwa kwe-colonoscopy enye indlela esetyenziswa ngayo. Xa inkqubo yenziwa nge-colonoscope, into engama-fecal isasazeka kuyo yonke ikolon, ekucingelwa ukuba iyasebenza ngakumbi. Xa i-tube ye-NG (indlela eqhelekileyo) isetyenziswe, izinto eziphathekayo zingasasazwa kuwo onke amathumbu amancinci kunye nawo onke amathumbu amakhulu. I- proton-pump inhibitor idlalwa ngexesha elifanayo ukwenzela ukukhusela ibhaktheriya encedo ekubulaweni ngamathambo esisu.
I-Fecal Bacteriotherapy Kwi-IBD
Enye yeengcamango malunga nezizathu ezinokubangela ze-IBD ziquka ukutshintsha kwebhaktheriya kwiimathumbu ezinkulu. Kucatshangelwa ukuba ukuba abantu abane-IBD banakho ukungabikho kweebhaktheriya kwikholoni, okanye kuninzi kwesinye, i-FB ingaba yonyango. I-FB iye yaphandwa kuphela ekusebenziseni kwi-IBD kwezinye iincinci, izifundo zokuqala, ngoko ukusebenza kungabonakali. Enye inkxalabo malunga nokusetyenziswa kwe-FB kukuvuma kwabantu abane-IBD ukuba bangene kwinkqubo. Abanye abaphandi benza uphando oluthile ukuze bafumane ukuba abantu abane-ulcerative colitis bayakuqwalasela i-FB, kwaye le ngcamango yavela ukuba yamukelwa kakuhle.
Kwaziwa kwakhona njenge: fecal microbiota transplantation (FMT)
Imithombo:
Kahn SA, Gorawara-Bhat R, uRubin DT. "I-bacteriotherapy ye-Fecal ye-ulcerative colitis: Izigulane zikulungele, ngaba thina?" I- Inflamm Bowel Dis 25 Meyi 2011 INGXELO: 10.1002 / ibd.21775. 31 Julayi 2013.
I-Tody ene-Borody, i-Warren EF, i-Leis S, i-Surace R, i-Ashman O. "unyango lwe-ulcerative colitis usebenzisa i-bacteriotherapy ye-fecal". J Clinic Gastroenterol 2003 Jul; 37: 42-47. 31 Julayi 2013.