Ingqwalaselo Yonke into esuka kwi-Acetaminophen ukuya eNorco
I-rheumatoid arthritis (RA) yisifo esisigxina kwisifo somzimba sokuzikhusela komzimba, ngokubangela ukuvuvukala kwe-synovium-izicubu ezihamba ngaphakathi kwamalungu. Intlungu kunye nokuvuvukala okubangelwayo kunokuba nzima kwaye kunzima. Ngethamsanqa, kukho iindidi ezahlukahlukeneyo zokunyanga ukuvutha okubangelwa yi-RA kunye nokunciphisa ukuphazamiseka kubangelwa. Nantsi ingqikquthela yeeklasi ezintlanu zezilwanyana ezisetyenziselwa i-RA kunye nendima nganye edlalayo ekuphatheni esi sifo esibuhlungu.
Izidakamizwa ezingezange-Steroidal Anti-Inflammatory
Izidakamizwa ezichasayo ezingekho komzimba , ezibizwa ngokuba yi-NSAID, ziyiqela elikhulu lamachiza elisezantsi elimiselwe ukunciphisa ukuvuvukala , intlungu, kunye nomkhuhlane.
Basebenza ngokuthintela i-enzyme ebizwa ngokuthi i-cyclooxygenase (COX) ekwenzeni i-prostaglandin-i-hormone-like-chemicals echaphazelekayo ekuvukeleni. I-COX-1 kunye ne-COX-2 ziintlobo ezimbini zeezymes. I-NSAID zendabuko, njenge- aspirin , i- naproxen , kunye ne- ibuprofen ibhloko zombini i-COX-1 kunye ne-COX-2. I-NSAID ezitsha, ezifana neCelebrex (celecoxib), zivimba kuphela i-COX-2 kwaye zaphuhliswa kuba i-COX-1 yaziwa ngokuba negalelo elifanelekileyo lokukhusela isisu esiswini.
Nangona ininzi ye-NSAIDS idinga imithi, ezinye zifumaneka kwi-counter ngaphakathi kwamandla amancinci, njenge- Advil (ibuprofen) kunye ne- Aleve (naproxen).
Uhlalutyo
Ama-analgesics yimishanguzo eyanciphisa intlungu. Zivame ukubizwa ngokuba yimichiza yintlungu okanye i-painkillers. Eli klasi lamachiza libandakanya i-analgesics engezange-narcotic njengeTylenol ( acetaminophen ) kunye ne-opioid narcotics ezifana ne- hydrocodone . I-narcotic ye-opioid ebizwa ngokuthi i-Ultram ( tramadol ) icingelwa ukuba inomngcipheko omncinci wokuba umlutha kunamanye ama-narcotic opioid.
I-Acetaminophen ifumaneka kwi-counter, kunye ne-odokotela kunye ne-opioid narcotics. U-Vicodin, uLortab, kunye noNorco ngamagama e-brand name medication aqukethe i-hydrocodone kunye ne-acetaminophen.
Corticosteroids
I-Corticosteroids , ebizwa nangokuthi i-glucocorticoids, yilezi ziyobisi ezilinganisa i-cortisol, i-hormone ngokwemvelo eyenziwa yi-adrenal gland echaphazela imisebenzi emininzi emzimbeni, kubandakanywa nesistim somzimba . I-Cortisol inako ukulawula ngokukhawuleza ukuvuvukala ngamanqanaba okuhla kweprotaglandines kunye nama- cytokines avuzayo .
I-Corticosteroids ezifana ne- prednisone inefuthe elifanayo ekuvukeleni. Kubalulekile ukuba uqaphele ukuba nangona kunjalo, i-corticosteroids inokubangela iziphumo ezingathandekiyo ezinjengezondlo ezininzi, ukufumana ubunzima, ukugcinwa kwamanzi kunye nokunyuswa kwengcinezelo yegazi-ingakumbi ukuba kuthathwa ixesha elide okanye kwiqondo eliphezulu . Ukuba ugqirha wakho ukubeka kwi-corticosteroid, kubalulekile ukuyithatha njengoko imiselweyo.
Izidakamizwa zokuguqula izifo ezichasayo
Izidakamizwa zokuguqula izidakamizwa (i-DMARD) izifo eziza kuhamba ngokukhawuleza ezisebenza emva kweempawu ekuqhubekeni kancinci kwesifo se- rheumatoid kunye nokunciphisa ingozi yomonakalo ohlanganyelweyo .
I-DMARD echazwe ngokuqhelekileyo i- methotrexate (ithengiswa phantsi kwegama legama elithi Rheumatrex neTrexall). Ezinye i-DMARD ziquka i- Plaquenil (i-hydroxychloroquine), i-Arava (i-leflunomide), i- Azulfidine (i-sulfasalazine) kunye ne-Otrexup, ifom e-single-injection of methotrexate.
Njengazo zonke iziyobisi, kubalulekile ukuqaphela imiphumo emihle. Ukuba ubona into echaphazelekayo, qhagamshelana nogqirha wakho. Uya kuba neenvavanyo zegazi ngexesha elizeleyo ukujonga i-enzyme yakho yesibindi ngelixa uphathwa nge-DMARD.
I-molecule encinane i-DMARD kuquka ne- JAK inhibitors ziphakathi kweendlela ezintsha. I-Xeljanz (tofacitinib) yenye yezo zinto. Isebenza ngokuvimbela indlela yeJAK ngaphakathi kweeseli ezenza indima ebalulekileyo ekuvukeleni ehambelana ne-rheumatoid arthritis.
Biologics
I-Biologics , ifutshane malunga ne-biologic response guides, iyona ndlela entsha yeDMARD. Benza i-genetically engineered from organic organism ukukhupha impendulo ethile. Ngamanye amazwi, i-biologics ijolise iprotheni ethile okanye iseli ehambelana neempawu kunye nomonakalo odibeneyo obangelwa ziintlobo ezivuthayo ze-arthritis. Ininzi yezinto eziphilayo ziyi-self-injection, kodwa ezinye zinikezwa nge-intravenously (ngokusebenzisa inaliti ibe yintlambo).
Imithombo:
> I-Arthritis Namhlanje Isikhokelo Sezidakamizwa. Arthritis Foundation. http://www.arthritis.org/living-with-arthritis/treatments/medication/drug-guide/.
> Firestein, et al. I-Kelley's Bookbook yeRheumatology . Lwe-9. Elsevier Inc. 2012.