I-Xolair (i-omalizumab) iboniswe ukunciphisa ukuhlaselwa kwesifo se- asthma ku-moderation ukuya kwi-asthmatics enzima, kwaye ukunciphisa okanye ukuphelisa imfuno yenye imithi ye-asthma .
Ngaba Ndiza kuzuza kwiXolair?
Ezinye izigulane ezine -asthma ezikhuselayo zenza i- IgE eninzi enokubangela ukunyuka kweempawu ze-asthma ezifana:
Ngokubanzi, unokufumana inzuzo kwiXolair ukuba unayo:
- I-asthma eqhubekayo engapheliyo okanye eqhubekayo
- Uvelwano kwi-allergen kunye novavanyo olungaqhelekanga lwe-allergies njengoRAST
- Ayifumananga impendulo enhle kwi-steroid enganyangekiyo njenge- Flovent okanye i-steroid engabonakaliyo kunye ne-agonist esebenzayo ende ende njenge- Advair .
Ukongezelela, ezinye izigulane ezine-asthma ezisebenzayo ezingakwazi ukuguqula indawo yazo yomsebenzi zingenelwa unyango kunye ne-Xolair. Abanye abatshutshisi abafana ne-Aetna kufuna iimfuno ezithile eziza kudibana phambi kokuvuma ukuhlawulwa kwe-Xolair ekuqaleni kunye nokusetyenziswa kwayo okuqhubekayo.
Ingaba isebenza kanjani?
I-Xolair yenza amanani amanqanaba ahlukeneyo anxulumene ne- asthma pathophysiology equka:
- IgE
- Iiseli ezincinci
- Basophil
Ngokusebenzisa amanyathelo ayo, amanqanaba e-IgE anciphisa kunye nomsebenzi we-basophil kunye neeseli zamathambo. Isiphumo siyancipha ukuvuvukala kunye nokungahambisani nokuhamba komoya okubangelwa ukuphuculwa kweeklinikhi ezikhankanywe ngaphambili.
Ngubani Ongathabatha I-Xolair?
Ungasebenzisa i-Xolair ukuba uneminyaka eyi-12 ubudala nangaphezulu.
IXolair ilawulwa njani?
I-Xolair yakho (omalizumab) isosi isekelwe kuwe:
- U bunzima
- Nqanaba le-IgE
Ngokuxhomekeka kwinqanaba lakho kunye ne-IgE level, uza kufumana i-injection engaphantsi (phantsi kwesikhumba) rhoqo kwiiveki ezi-2-4. Udinga ukufumana ii-injections ubuncinane kwiiveki ezili-12 ukuze ubone ukuba i-Xolair isebenza ngempumelelo kuwe.
Ukuba ufuna ukuyeka i-Xolair ngenxa yemiphumo emibi okanye esinye isizathu, iziphumo zonyango ziya kuqala ukugqithisa kwaye ziya kuhamba ngeenyanga ezi-6. Akukho zibonelelo ezihlala ngonaphakade zokufumana ii-injections.
Ngenxa yomngcipheko we-anaphylaxis, uya kufumana i-Xolair injections kwiofisi yakho yonyango kwaye kufuneka uhlale ixesha elide ukuya kwiiyure ezingama-2 ukuqinisekisa ukuba awukwazi ukuphendula. Ugqirha wakho unokukunika kwaye akufundise malunga ne- EpiPen okanye i-epinephrine injector ukuba uyisebenzise xa uhlakulela iimpawu ze-anaphylaxis ngaphandle kweofisi.
Iziphumo ezimbi
Kwizifundo zeklinikhi ukufumana i-Xolair evunywe yi-FDA, ibonakala ikhuselekile kakhulu. I-Xolair inikwe abantu abangaphezu kwe-2000 kunye nabaselula kwiminyaka engama-12. Ngomhla kaJanuwari 2010, oku kuquka izigulane ezingaphezu kwama-1600 ezisebenzisa i-Xolair ngaphezu kweenyanga ezili-6 kunye nezigulane ezingaphezulu kwama-550 zisebenzisa i-Xolair ngonyaka okanye ngaphezulu.
Iziphumo eziqhelekileyo ezibi zenzeke ngokumalunga kwizigulane zombini ezithatha i-Xolair kunye nabathatha indawo ye-placebo. Kukho nenani leempembelelo ezingathintekiyo ezinokuthi umntu uyazi ukuba zombini ngaphambi kokuqala unyango kunye ne-Xolair kwaye uzihlolisise ngokukhawuleza nomboneleli wakho wokunakekelwa nge-asthma.
Ngethamsanqa, iziphumo ezibi kakhulu zibonakala zenzeke ngaphantsi kwe-1% yezigulane eziphathwe nge-Xolair.
Ulwazi lwezokhuseleko lwe-Xolair lubandakanya isilumkiso esibalulekileyo seNobhokisi yeBhokisi enxulumene ne-anaphylaxis kunye nesinye isilumkiso esinxulumene nomhlaza .
Xolair Safe?
Izigulane ezininzi zihlala zibuza imibuzo malunga nokuba unyango oluthile lukhuselekile okanye cha. Ekubeni zonke iziyobisi zinemiphumo emibi, lo mbuzo uphuzisa ngokugqithiseleyo ukuba wena kunye nogqirha wakho bacinga ukuba iziphumo ezinobungozi ze-Xolair zikhulu okanye zingaphantsi kuneenzuzo zakho. Wena kunye nogqirha wakho kufuneka ube nencoko ethetha ngengozi kunye neenzuzo ngaphambi kokuba wenze isigqibo.
Ingaba ibiza malini?
I-Xolair iyabiza kakhulu, ukusuka kwi-$ 500 ukuya kwi-$ 2000 ngenyanga. Thetha nogqirha wakho malunga nokufumana inkxaso yomshuwalense kule nyango.
Imithombo:
I-Xolair Web Site. Xolair Ukuchazela Ulwazi
Barnes PJ. Anti IgE unyango. www.UpToDate.com