Abafazi nabasetyhini abakhulelweyo abazama ukukhulelwa beva lonke ixesha: Qiniseka ukuba uthatha i-folic acid. Ewe, i-folic acid ibalulekile kuba inokunciphisa iziganeko zokukhubazeka okuzalwa njenge-spina bifida kunye ne-palate palate. Kodwa ngenxa yezigidi zabasetyhini (kunye namadoda) anesimo somzimba esivimbela ukuba bakwazi ukusebenzisa i-folic acid ngokufanelekileyo, le ngcebiso inobungozi kwaye inokubangela ukuba i-miscarriages neempembelelo zempilo ebalulekileyo kumama nomntwana.
Nakhu okufuneka abafazi abane-PCOS bazi malunga ne-folic acid.
Yiyiphi iFillic Acid?
I-acid ye-folic iyinqobo yokwenziwa komgangatho wesondlo esenziwe kwiibhubhoratri. Isetyenziswe kuma-multivitamines, iivithamini zokubeletha kunye nezinye izongezo, kwaye isetyenziselwa ukuqinisa ukutya. Ngomnyaka ka-1998, kwakusungulwe isigunyaziso sikaRhulumente esenza abavelisi bemveliso yengqolowa ukuba baqinise umgubo wabo kunye ne-asidi folic ukwenzela ukunciphisa amazinga okukhubazeka kokuzalwa. Iindidi eziqhelekileyo zokutya ezinama-folic acid ziquka kuwo ukutya, i-pastas, isonka, abaqhiqizi kunye nezinye ukutya okuziinkozo ezipakishwe. Uyabona ipesenti ye-folic acid efakwe kwileyile yokutya. Ngaphandle kwalo mgaqo usebenza kubakhiqizi bezinto eziphilayo okanye abangenabo i-GMO abangenayo imfuneko yokuqinisa ukutya nge-folic acid. Ngaloo ndlela, uya kubona ngokuphantsi okanye akukho nxalenye ye-folic acid ekudleni kokutya.
Yiyiphi Inkoliso?
I-folate, ngamanye amaxesha ekuthiwa yi-vitamin B9, isondlo esifumaneka ngokwemvelo ekudleni konke, njengeziqhamo, imifuno (ingakumbi imifino emnyama), iimbotyi kunye neententili.
I-folate yinxalenye yeeseli ezibomvu zegazi kunye neendima ezibalulekileyo emzimbeni. Ezi zibandakanya ukuba yinxalenye ye-DNA kunye ne-RNA synthesis, ukuxosha umzimba weexinxu kunye nokuxhaswa kwe-immune system, ukuguqula i-amino acid, kunye nokukhula kweseli. I-folate ibalulekile ekuphuhlisweni kwenkqubo ye-nervous central embryos, oko kutheni iimfuno zentando ziphezulu xa zikhulelwe.
Ndiyaphi Inkoliso Ndiyayifuna?
Abafazi abadala bafuna ii-microgram ze-400 ze-folate nsuku zonke. Abo ba khulelwe okanye bazama ukukhulelwa badinga i-600 microgram nsuku zonke. Ezi zixa zinokuba nzima ukufumana ukutya kuphela. Ukuba awukwazi ukucwangcisa i-acid ye-folic, unokukwazi ukufaka indawo ye-multivitamin okanye isongezelelo sokubeletha esine-5-methyltetrahydrofolate (5-MTHF) okanye i-acid folinic, apho umzimba uya kukwazi ukuyisebenzisa ngokufanelekileyo.
Yintoni eyenzekayo xa ungeke ukwazi ukuhlaziya iifayile?
Ngenxa yokuba inxaxheba kubandakanyekayo kwiinkqubo ezinkulu emzimbeni, ukungabi nako ukuwusebenzisa kungabungozi kwaye kunokubangela ukuba kubekho ingxaki emininzi yexesha elide (jonga ngezantsi). Abanye abantu (abaninzi abangakwaziyo) banesiphako semfuza ekusebenzeni kwabo ukusebenzisa i-folic acid. I-Methylenetetrahydrofolate iyanciphisa, okanye i-MTHFR, imeko yezofuzo ezichaphazela malunga nama-10 ukuya kwe-15 kweepesenti zaseCaucasus kunye nama-25 engama-25 ekhulwini labantu baseSpanike. I-MTHF ibini i-gene kunye ne-enzyme eyanceda ukuguqula i-folic acid ibe yindlela efanelekileyo yokusebenzisa. Omnye onokuhlukana kwe-MTHFR akanako ukusebenzisa i-folate ngokufanelekileyo.
Izimo zeMpilo ezihambelana neMTHFR
Nangona ukuguquguquka kwezakhi zofuzo kweMTHFR kunokuchaphazela ukuzala, kungabangela ukuba nempilo yexesha elide.
Nazi ezinye zeemeko zempilo ezinxulumene nokungakwazi ukusebenzisa i-folic acid ngokufanelekileyo:
- Ukudandatheka okanye ukuxinezeleka kwe-postum partum
- Ukuxhalabisa
- Ukungenzi lutho
- Migraines
- I-irritable bowel syndrome
- Ukuvutha
- Amacwecwe egazi
- Cancers
- Isifo sokunyamezela esingapheliyo
- Ukungakwazi ukucoca ngokufanelekileyo
- Ukungasebenzi kumzimba
- IAnemia
- Isifo sentliziyo
- Stroke
I-MTHFR kunye neNgenalo
Njenge-enzyme, i-MTHFR inceda ukuguqula i-amino acid homocysteine kwi-methionine. Le nkqubo ibalulekile kwimpilo yeentliziyo, ukuxutywa kwe-detoxification, kunye nokuzala.
Ukuba i-homocysteine ayiyi kuguqulwa ibe yi-methionine, amanqanaba amazinga e-homocysteine aya kwakha kule nkqubo.
Amanqanaba e-homocysteine aphezulu adibaniswa nokulahleka kwamathambo ngokuphindaphindiweyo njengoko kukwandisa umngcipheko weengcambu zegazi kwi-placenta okanye kumntwana.
Ukungakwazi ukusebenzisa i-folate ngokufanelekileyo kunokuchaphazela nokusetyenziswa kwezinye izondlo ezibalulekileyo ezifana ne-vitamin B12, i-coenzyme Q10 kunye nezinye ii-vitamini ze-B ezibalulekileyo kwimpumelelo yeqanda. Abafazi abaninzi abane-PCOS bazama ukuvelisa umgangatho ofanelekileyo wamaqanda esele ngenxa yokungalingani kwama-hormone wesini esithintela i-oocytes ekukhuliseni kakuhle.
Ngokufanelekileyo, bonke abafazi abaceba ukukhulelwa kufuneka bahlolwe ukuguqulwa kweMTHFR ngaphambi kokukhulelwa.
Ndingazi njani ukuba ndibe neMTHFR Mutation?
I-gene ye-MTHFR ikwazi ukuvavanywa kalula. Thetha nogqirha wakho ukufumana uvavanyo lwegazi kwi-MTHFR. Ekubeni kuninzi ezahlukeneyo zohlobo lwe-MTHFR, ukungazi ukuba yeyiphi ifomu onayo iya kubeka inkcazo yakho yonyango.
Iingcebiso zokuPhucula ubuNtu bakho
Ukuba unesimo sokutshintshwa kweMTHFR, kukho utshintsho oluninzi ongakwenza kwisondlo sakho ukuphucula ukuzala kwakho.
Gwema i-Endocrine Amachiza aphazamisayo
Ngokuqhelekileyo kufumaneka kwiibhotile zeplastiki, iibhotile zamanzi kunye neepisiti zamaphepha, iikhemikhali eziphazamisa i-endocrine (EDCs) zingakhokelela ekwakheni i-toxin ephezulu kwinkqubo yakho enokuba nzima ukuba umzimba wakho ususe. Ukutya ukutya okuninzi kunye nokusela okucoca amanzi kunokuncedisa ukunciphisa ukutshiswa kwe-toxin.
Yidla izityalo ezininzi kunye nemifuno
Iintyatyambo kunye nemifuno ziyimithombo emihle yezinto ezinjengobuncwane. Eminye imithombo ephezulu ye-folate ifumaneka kwiimbotyi, i-lentils, imifino, i-avocados, i-asparagus kunye ne-broccoli.
Gwema ukutya okuPhezulu
Ukutya okucwangcisiweyo kuqiniswe i-folic acid. Ukuphepha ezi ntlobo zokutya kuya kunceda ukunciphisa ukukhanya kwakho kwe-folic acid.
Cinga ngezinye iziNcediso
Thetha ugqirha okanye umboneleli wezempilo malunga neyiphi eyongezelelweyo enezondlo onokuyifumana. Iziqhamo eziqhelekileyo ezithatyathwe ngabantu abane-MTHFR mutation ziquka i- vitamin B12 , i-coenzyme Q10 kunye namanye amavithamini B.
Ukuba ne-genetic mutation MTHFR inokuchaphazela ukukwazi kwakho ukuba nomntwana. Ukwazi ukuba unayo i-varitic genetic and taking steps to manage it, kuya kukunceda ukuba ukhulelwe kakuhle kwaye uphucule impilo yakho.
> Imithombo
> I-Hickey S. ACMG Isikhokelo sokuSebenza: ukungabikho kobungqina bovavanyo lwe-MTHFR yokuhlola i-polymorphism. UGenet Med 2013: 15 (2): 153-156.
> Thaler CJ. I-Folate Metabolism kunye nokuzaliswa kwabantu. Geburtshilfe Frauenheilkd. 2014 Sep; 74 (9): 845-851.