I-MTHFR Gene ne-TRPV1 Gene egalela i-Migraines
Ukuba unesifo sokukhubazeka kwemigraines, kukho ithuba elihle lokuba udade wakho, umzala okanye umama wenza njalo. Oku kungenxa yokuba iizakhi zakho zegesi zikuncipha ngakumbi okanye zenzeke kakhulu ekuphuculeni imigraines.
Makhe sihlolisise i-genetics ye-migraines kwaye oko kuthetha ukuthini wena nentsapho yakho.
Ukusebenzisana phakathi kweGenesis ne-Environment kwi-Headaches
Ubuninzi beentloko bubangelwa yimimandla ehlukahlukeneyo yezofuzo kunye neendawo ezisingqongileyo ezibandakanya kwiwebhu.
Ngelixa uninzi lwenu nisebenzela ngokungapheliyo ekulawuleni imo engqongileyo ngokukhusela ukukhutshwa nokuguqulwa kokuziphatha, ngokucacileyo awukwazi ukutshintsha iizakhi ozalelwe ngazo. Nangona kunjalo, ngokufunda i-genetics echaphazelekayo kwimvelaphi ye-migraine, izazinzulu zingenza amayeza amtsha ajolise kwizityalo ezithile, ngeentembelo zokuphilisa, ukuba kungenzi ukunciphisa iintloko zethu ezinzima kunye nezilimazayo.
Ziziphi iintlobo zeGenesis ezibandakanyeka kwi-Migraines?
Kukho indima ebalulekileyo yelifa ekuphuhlisweni kwemigraines nezinye iintloko eziphambili . Oku kuye kwaboniswa ngeentsapho ezininzi kunye nezifundo ezimbini. Kodwa zithini iigesi ezidlulileyo? Ngezantsi umzekelo wezinto ezimbini zegesi ezicinga ukuba zidlala indima ekwakheni imigraines.
Umzimba omnye ubizwa ngokuba yi- MTHFR gene , emele ixesha elide, i-methylenetetrahydrofolate iyanciphisa. Lo mzimba ubandakanyeka kwindlela ye-homocysteine. I-Homocysteine i-amino acid egazini lethu elithe xa liphakanyisiwe, lingakhokelela ekuveliseni umlotha wegazi, kunye nokuqhuma kweeseli ezithile zeentsholongwane ezingabandakanyeka entloko.
Ukuguqulwa okunye kule mfuza kudibaniswe kunye kokubili imigraines kunye neentloko zeentloko .
Olunye uphando kwi- Pharmacogenetics kunye neGenomics lubone ukuba kwabasetyhini abane- migraine ne-aura , ukuxhaswa kwe-vitamin kunciphisa kakhulu amanqanaba abo ase-homocysteine, ukunyamezeka kwemigraine, kunye namanqanaba okukhubazeka, xa kuthelekiswa nabasetyhini abathatha indawo.
I-vitamin B6, B9 (folic acid), kunye ne-B12, efunyenwe kumanqanaba e-homocysteine aphantsi kwegazi.
Ukongezelela, xa iqela elinolawulo lwe-vitamin lihlolisiswa ngokukhawuleza, kwafunyaniswa ukuba izigulane ezinezityalo ezithile ze-MTHFR zinezinga lokunciphisa kakhulu kumazinga ase-homocysteine, kunye nokunyaniseka kwamagrafini kunye nokukhubazeka kwamanani, kunokuba abo bahluke . I-allele yindlela ehlukile ye-gene ephethe indawo ethile kwichromosome ethile. Oku kufunyanisiweyo kubonisa ukuba ukuhlukahluka kwezinto ezithile zentsholongwane kunokuchaphazela indlela abahamba ngayo ngokufanelekileyo baphendukela kwi-vitamin supplementation.
I-TRPV1 (Ixesha elifutshane elinxulumene noNcedo lwe-Vanilloid Uhlobo 1) luye lwacetyiswa ukuba ludlale indima ebalulekileyo ekukhuthazeni i-migraine -igama elibhekiselele kwinkqubo enomdla kakhulu okanye esebenzayo kwiigulane ezine-migraines.
Lo mzimba udlala indima kwimigraine hyperalgesia ne- allodynia , iimeko ezimbini ezinokuthi zenzeke ngexesha lokuhlaselwa kwe-migraine. I-Hyperalgesia ibhekisela kwimpendulo eyongeziweyo kwi-stimulus ebuhlungu. I-Allodynia ibhekisela kwimpendulo ebuhlungu kwisimo esingaqhelekanga esingenakulimala, njengokuba ungonwabi ngothinta olulula ngexesha lokuhlaselwa kwe-migraine.
Kule minyaka embalwa edluleyo, iziyobisi ezijolise kwiitrato ze-TRP ziye zafundwa njengendlela yokuthatha imithi yokuthatha imithi.
Omnye umzekelo weziyobisi ezijolise kwisiteshi se-TRPV1 ngu- sumatriptan , unyango oluqhelekileyo lwe-migraine.
Lithetha ntoni Oku?
Umfanekiso omkhulu apha apha kukuba i-migraines inesiseko esisigxina sezofuzo. Ngokufunda okungakumbi malunga namajethi athile axhomekeke kwelinye kwi-migraines, izazinzulu ziza kugxininisa iziyobisi kulezi zintlobo.
Kwakhona, ukuqonda i-genetic migraine kunokuthi kunciphise ezinye zeziganeko zomntu ngamnye, njengoko zizama ukulawula ukuhlaselwa kwabo kwe-migraine. Cinga ngokuxoxa ngembali yakho yentsapho kunye nomboneleli wakho wezempilo, njengoko oku kunokunika ingqiqo kwimigraines yakho kunye nokuchaphazela unyango oluzayo.
Imithombo:
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Imilinganiselo JE, Neeb L, Reuter U. TRPV1 kwi-migraine pathophysiology. Iintlobo zeMol Med. 2010; 14 (4): 153-159.
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