Nangona kungakhange kuboniswe ukuphatha i-polycystic syndrome syndrome (i-PCOS), i- metformin yimiyeza echazwe ngokuqhelekileyo ekuncedeni abasetyhini abanezimo. Uphando olutsha olonakalisayo lubonisa ubudlelwane phakathi kokusetyenziswa kwexesha elide kunye ne-vitamin B12, kodwa uninzi lwababoneleli bonyango abanqabile ukujonga isimo seB12 kubasebenzisi be-metformin. Ukungabikho kwe-vitamin B12 kunokubangela ukuba umonakalo omkhulu kwaye unaphakade unomonakalo.
Nantsi into oyaziyo malunga ne-vitamin B12 xa uthatha i-metformin.
Yintoni i-Metformin?
I-Metformin isebenza njenge- insulin-sensitizer ukunciphisa imveliso yakho ye-glucose kwaye iqheleke ngokuqhelekileyo kubantu abane-type 2 yeswekile ngenxa yesi sizathu. Amanye amagama e-metformin afaka i-glucophage, i-glucophage XR, i-glumetza, ne-fortamet.
I-Metformin iyanciphisa i-blood glucose kunye namazinga e-insulin ngeendlela ezininzi: Inqanda ukuveliswa kwesibindi se-glucose, ikhulisa ubukhulu besibindi sakho, i-muscle, i-fat, kunye neeseli kwi-insulin umzimba wakho wenza, kwaye unciphisa ukuxutywa kwe- carbohydrates oyidlayo.
I-Metformin iboniswe ukuphucula i-insulin kunye namanqanaba e-lipid (i-cholesterol) kubafazi abane-PCOS kwaye inokunceda ukuphucula i-ovulation.
Usetyenziso lweMetformin kunye ne-Vitamin B12
IsiPhumo soPhulo lweSifo seSetyhufu IsiPhuculo (iDDPOS) sithetha enye yezona zifundo ezinkulu kunye nezona zide kakhulu zonyango olukhoyo lwe-metformin. Uhlalutya olutsha lwe-DDPOS olupapashwe kwiNcwadi ye-Clinical Endocrinology kunye neMetabolism ibhekise kumanqanaba eB12 abantu abane-prediabetes abathabatha i-850 mg yeMetformin kabini imihla ngemihla bafanisa nabo bathatha indawo ye-placebo.
Amazinga e-Vitamin B12 ahlolwe kwi-5 ne-13 iminyaka.
Iziphumo ezivela kwi-DDPOS zibonise ukuba ukusetyenziswa kwexesha elide le-metformin kwandisa umngcipheko wezinga le-vitamin B12. Kwiminyaka emi-5, i-5.2 ekhulwini yabasebenzisi be-metformin babenamazinga aphantsi e-serum B12. Kwiminyaka engama-13, i-9.2 ekhulwini yabasebenzisi be-metformin babe namazinga aphantsi a-B12. Xa ukulawula iminyaka yobudala, isondo, kunye ne-BMI, bekukho iipesenti ezi-13 zandisa ubungozi bokunqongophala kwe-B12 kunyaka ngamnye wokusetyenziswa kwe-metformin.
Kukholelwa ukuba i-metformin inokuchaphazela ukuxutywa kwe-vitamin B12 kwi-ileum yesisu esincinci. Amazinga e-vitamin B12 awachaphazelekayo kuphela kwisifundo se-DDPOS, kodwa amanqanaba e-homocysteine, ummakishi weengozi zengqondo yomzimba, yanda ngaphezu kwexesha kubasebenzisi be-metformin.
Ezinye izifundo zibonise ukuba i-metformin inokuphazamisa amanqanaba e-vitamin B12 kwiinyanga ezimbalwa zokusetyenziswa. Ukuphononongwa ngokuchanekileyo kunye nokuhlaziywa kwemeta kubheka abantu abane-type 2 yeswekile kunye nabasetyhini abane-PCOS abathabatha i-metformin. Iziphumo zabo zifumene phezulu i-doformin dose, abantu abangenalo i-vitamin B12 kwaye i-metformin iyanciphisa amazinga e-vitamin B12 emibini (iminyaka emithathu) kunye nemfutshane (<3 iminyaka).
Umlinganiselo wesilinganiso se-metformin kubasetyhini abane-PCOS ngu-1,500 mg ukuya kwi-2,000 mg imihla ngemihla. Ininzi yabasetyhini abane-PCOS ithatha amanani aphezulu e-metformin ukusetyenziswa kwexesha elide, ukwandisa umngcipheko we-vitamin B12.
Ukubaluleka kweVithamini B12
Iivithamini zamanzi ezinqabileyo zamanzi, i-B12 ibalulekile ekuqhubeni iimbilini, ukusebenza kwengqondo, ukusetyenziswa kwe-DNA kunye nokubunjwa kweeseli zebomvu. I-Vitamin B12 ifunyanwe ikakhulu kwimveliso yezilwanyana. Abo ba landela ukutya kwe-vegan kufuneka bancedise ukutya kwabo kunye ne-vitamin B12. Inani eliphakanyisiweyo lemihla ngemihla le-vitamin B12 kubantu abaninzi abadala ngabantu abayi-2.4 mcg.
Iimpawu zokunqongophala kwe-B12 ziquka iintlobo ezithile ze-anemia, i-neuropathy (umonakalo weentlanzi), ukukhathala okungapheliyo, ukulahleka kwememori, ukudideka, ukuguquka kwemizwelo kunye nokudemeka kwengqondo.
Ukungabikho kwe-vitamin B12 kunzima kakhulu, kuthintela imizwelo kunye namandla kwaye kunokubangela ukuba neuropathy isigxina kwaye ingapheliyo. Ngamanye amaxesha ukuthatha i-multivitamin ene-vitamin B12 isenokubangela ukusilela kubasebenzisi be-metformin. Abantu abathi bathatha i-metformin kufuneka bahlaziywe ngamazinga abo e-vitamin B12 rhoqo ngonyaka kwaye bancedise ukutya kwabo ngokufanelekileyo. Uhlobo lwe-methylcobalamin lwe-vitamin B12 kwifom yobuncinane (ngaphantsi kolwimi) luhle kakhulu kumzimba.
Ukunqongophala kwe-Vitamin B12?
I-sampuli yegazi inokuhlola amazinga e-vitamin B12. Kuye kucetyiswa ukuba udidi lweembalo zobhaliso zamanqanaba eziqhelekileyo zeB12 zibekwe phantsi kwaye iimpawu zokuntuleka zingabonakalisa kumanqanaba angaphantsi kwe-400 pg / ml.
Ukuhlola i-methylmalonic acid (i-MMA) luvavanyo oluvakalayo olunokubonisa ngokuchanekileyo isimo se-vitamin B12.
Inqaku eliphantsi: Ukuba uthatha i-metformin, cela udokotela wakho ukuba ahlole amanqanaba akho e-vitamin B12 ngonyaka kwaye uncedise ukutya kwakho nge-vitamin B12 ukukhusela iingxaki zokungabikho.
Imithombo:
Aroda VR, et al. Ukusetyenziswa kwexesha elide leMetformin kunye ne-Vitamin B12 Ukusilela kwiSifundo soPhulo lweSiphumo soPhulo lweSifo seSetyhu. J Clin Endocrinol Metab. 2016; nceda: 10.1210
I-Greibe E, i-Trolle B, i-Bor MV, iLauszus FF, i-Nexo E. i-Metformin iyanciphisa i-serum cobalamin ngaphandle kokuguqula ezinye iimpawu ze-cobalamin isimo: isifundo kwabasetyhini abane-polycystic ovary syndrome. Amanzi. 2013 Julayi 5; 5 (7): 2475-82.
Ho M, Halim JH, Gow ML, El-Haddad N, Marzulli T, Baur LA, Cowell CT, Garnett SP. I-Vitamin B12 kwiintsholongwane ezithandanayo kunye nemisebenzi yeklinikhi yokuxhatshazwa kwe-insulin. Amanzi. Ngomhla wama-4 ku-4: 4 (12): 5611-8. i-doi: 10.3390 / nu6125611.
Ingole JR, Patel RD, Ingole SJ, iPandave HT. Ukunyuka kweeVitamin B12 Ukunqongophala kwi-IT Professionals Ukunikela kwi-Checkout ye-Health. J Clin Diagn Res. NgoDisemba ka-2015; 9 (12): OC01-OC02.
Ko SH1, Ko SH1, Ahn YB1, Ingoma KH1, Han KD2, iPark YM3, Ko SH1, Kim HS1. Umbutho we-vitamin B12 kunye nokusetyenziswa kwe-metformin kwizigulane ezine-type 2 zeswekile. J Korean Med Sci. 2014 Julayi; 29 (7): 965-72.
Liu Q1, Li S1, Quan H1, Li J1. Isimo seVitamin B12 kwizigulane eziphathwe nge-metformin: ukuhlaziywa okucwangcisiweyo. PLoS One. 2014 Juni 24; 9 (6): e100379.
Niafar M, Hai F, Porhomayon J, uNader ND. Indima ye-metformin kwi-vitamin B12 i-lack: ukuhlaziywa kwe-meta-analysis. Intern Emerg Med. 2015 Feb; 10 (1): 93-102.