Ngaba uye wakha wazibuza ukuba ngaba kukho nawuphi na umehluko phakathi komqondo weengxaki kunye nemizimba ye-Lewy kunye nesifo sengqondo sikaChinsinson? Ukuba uwake wayiva iimpawu zezi zimbini iziphazamiso, zivakala ngokumangalisa ngokufanayo. Kungenxa yokuba bobabini iintlobo ze-Lewy yokugula komzimba.
Lewy Body Dementia
Kukho iintlobo ezimbini ze-Lewy emzimbeni wengqondo: ukugula komzimba kunye nemizimba ye-Lewy (DLB) kunye nesifo sengqondo se-Parkinson (PDD).
Izimpawu ezabelwana ngazo ze-PDD kunye ne-DLB
Ukuqonda umahluko phakathi kwe-PDD ne-DLB, kubalulekile ukuqonda ukuba kukho iiseti ezimbini zeempawu ezenzeka kwi-PDD kunye ne-DLB.
- Ibhunga : Izimpawu ezichaphazela umzimba ziquka ubuthathaka obuthathaka, ubunzima (ukuqina) kunye nokunyameka ekuhambeni.
- Ubungqina : Izimpawu ezibonakalayo kwingqondo zibandakanya ukusebenza okusemthethweni, ukukhathazeka kunye nokulahlekelwa kwememori.
Zombini ezi ntlobo ze-dementia zinempawu ezichaphazela umzimba kunye nengqondo. I-hallucinations kunye nokudakumba kudla rhoqo kwiintlobo zombini zomqondo weengqondo, ngokunjalo. Ezi zombini iimeko zihlala ziphathwa ngamachiza asemiselweyo kwisifo se-Parkinson , njenge- carbidopa-levodopa (iSinemet) , esinokukunceda ngokuphucula ikhono lokuhamba kunye nokusebenza ngokomzimba, kunye nokunciphisa imithi ye-inhibitor , enokunciphisa ukuncipha kwengqiqo .
Ulwahluko phakathi kwePDD kunye neDLB
Ngoko, iPDD neDLB zihluke njani komnye?
Oko kuxhomekeke kubani oyicelayo. Ezinye iiklinikhi zivakalelwa kukuba ezi zimbini ziimeko zihlukileyo zenguqu efanayo. Enyanisweni, ndide ndive ochwepheshe abathile basebenzisa amagama ngokungafaniyo. Nangona kunjalo, ngokwemiqathango ekhoyo ngokuvumelana nokuxilongwa, kukho ukungafani.
Umehluko omkhulu phakathi kwesifo se-Parkinson nesifo sengqondo somzimba kunye nemizimba ye-Lewy ngumyalelo wokuqala kweempawu.
Oogqirha baqhele ukuhlukanisa phakathi kwezi zinto ngokubuza ukuba yeyiphi impawu (umzimba okanye ingqondo) yabonakala kuqala.
Ukuxilongwa kwesifo sengqondo sikaParkinson, iimpawu zeemoto kunye nokunyakaza, kuquka ukuqina, ubuthathaka kunye nokuthuthumela, kufuneka kube khona ubuncinane omnye unyaka ngaphambi kokuhlaselwa kwengqondo.
Izidumbu zemizimba ye-Lewy ifunyaniswa ukuba iimpawu zokuhamba kunye nobuthakathaka be-muscle zenzeka ngexesha elifanayo njengokuncipha kwengqondo, ukuba iimpawu zengqondo zivele phambi kweempawu zeemoto, okanye ukuba ukuhla kwezinto ezinokuqonda kunokukhula kungaphantsi konyaka emva kokuba iimpawu zemoto ziqala.
Ngaba kukho naziphi ezinye iintlukwano?
Utshintsho kwiCognition
Abantu abane-dementia kunye nemizimba ye-Lewy bavame ukubonisa ukuhluka okukhulu kunokwakheka kwengqondo kunabo abanesifo sengqondo se-Parkinson. Oku kubalulekile ukuqonda ukuba amalungu entsapho kunye nabanonophelo bangakhathazeka baze bakholelwe ukuba umntu ukhetha ixesha (okanye ukudibanisa) ukukhubazeka kwakhe kwengqondo.
Ukuqonda ukuguqulwa kwamandla kwengqondo kubalulekile nokuvavanya nokuhlola. Abantu abanesifo sengqondo sika-Parkinson bangenza okufanayo kwiimvavanyo zengqondo nangona uvavanya ngamaxesha ahlukeneyo emini okanye kwiintsuku ezahlukeneyo.
Nangona kunjalo, umntu onomdemokhrasi kunye nezidumbu ze-Lewy angabonisa imemori ephuculweyo okanye ngokugxininiswa ngamanye amaxesha kwaye ngokugqithiseleyo ukugqithisekisa ukuqonda kwamanye amaxesha. Ngaloo nto, kubalulekile ukuqhuba uvavanyo oluqikelelwayo ngaphezu kweyodwa ukuvavanya ngokuchanekileyo umntu onomdemokhrasi kunye nemizimba yaseLeyy.
Iindlela zokulala
I-DLB ihlala ichaphazela ukulala ngokubaluleke kakhulu ngenxa yokukhubazeka kokulala kwe-REM, imeko apho abantu baphatha khona amaphupha abo njengoko belele, kuqheleke kakhulu kwiinqanaba zokuqala ze-DLB xa kuthelekiswa ne-PDD. Oku kudla ngokuba ngumqondiso osasazekayo weLeby we-mental dementia.
Izizathu zePDD kunye neDLB
Zombini iintlobo zengqondo ye-dementia zibonakaliswa kubukho be-bodyy Lewy ebuchosheni, i- atrophy yeeseli zengqondo kunye neengxaki ze-acetylcholine.
Zomibini iintlobo zomdemokhrasi (nangona le nto ingaba yinto eqhelekileyo kwi-DLB) inokuthi ibe neprotheyini ye- betyloid ye-beta kwi-ingqondo, nokuba yiyiphi impawu zesifo se-Alzheimer .
Imithombo:
Deutsches Arzteblatt International. 2010 Oktobha; 107 (39): 684-691. I-Lewy Body kunye ne-Parkinsonian Dementia. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957617/
Umbutho we-Lewy Body Dementia. Iintlobo ze-Lewy Body Dementia. http://lbda.org/content/lbd-booklet/types-of-lbd
Neurology. Umqulu 68 (11), 13 Matshi 2007, iphepha 812-819. Imiba engumda we-DLB kunye ne-PDD: Ukuxilongwa, unyango, isifo se-molecular and biomarkers. http://www.neurology.org/content/68/11/812.abstract?sid=be7f0348-f70f-4b92-b56f-e09ba641b396
I-Parkinson's Disease Society yaseUnited Kingdom. I-Q & A: I-Dementia ne-Parkinson. http://www.parkinsons.org.uk/content/qa-dementia-and-parkinsons