I-Irritable Bowel Syndrome kunye neNystem System
Ukungasebenzi kumxholwana phakathi kwengqondo kunye nesisu kuya kuba yinto ebangela ukuba isifo sengqondo sesifo esilumkileyo (IBS).
Ezinye iingxaki zempilo zilula ukuqonda. Ukuba unesifo somqala , ugqirha wakho uya kuthatha isampuli yesisu emqaleni wakho kwaye uqhube uvavanyo ukuze ubone ukuba unesifo sosulelo lwe-strep. Umlenze oqhelekileyo ojongene nesikhumba sakho unokuvavanywa ukuze ubone ukuba unomdlavuza.
Ngelishwa, i-IBS ayikulula. Ngokungafani nezifo ezibonakalayo, ukuqonda okokungahambiyo kwi-IBS, abaphandi baye bafumanisa ukuba kufuneka bajonge ngaphaya kwamanzi kunye neendlela ezixakekayo zonxibelelwano ezidibanisa umthambo ebuchosheni.
Ukuxabisa ngokwenene umsebenzi owenziwa kule ndawo, kuya kufuneka ube neyure kwi-neuroscience. Ngaphandle kwanaloo nqanaba, kuyakunceda ukuba ube nolwazi olusisiseko lwentsebenziswano oluyinkimbinkimbi phakathi kwengqondo kunye nesisu kunye nendlela oku kuhambelana ngayo ne-IBS.
ZeBioology
Bona ukuba naziphi na iingxoxo ezilandelayo zenza intsimbi evela kwixesha lakho elichithwe kwiklasi ye-biology ephakamileyo. Ukunxibelelana phakathi kwazo zonke iinxalenye zomzimba wethu kwenzeka ngokudluliswa kolwazi kwi-nerv to nerve. Nantsi inkcazo elula yendlela eyahlukeneyo apho le nxibelelwano yenzeka khona:
- Inkqubo yesantya ephakathi (CNS): ingqondo kunye nomgca womgogodla
- Inkqubo yentsholongwane ye-Peripheral (PNS): iindlela zentliziyo ezidlulela ngaphaya kwengqondo kunye nomthambo womgudu.
Inkqubo ye-nervousal system iyabelana ngokwengeziwe kwiindawo ezimbini:
- Inkqubo yesantya yeSomatic: ixanduva lokulawula ngokuzithandela izihlunu kunye nokuphendulela kwiimvakalelo zangaphandle.
- Inkqubo yesantya ye-Autonomic : ijongene neempendulo zeemoto kunye nezivelelo zamalungu ethu angaphakathi ( viscera ).
Inkqubo yeNervous System
Inkqubo ye-nervous system (ENS) inxalenye yenkqubo ye-neon autonomic ejongene nokulawula inkqubo yokugaya. I-ENS ilawula i- motility (ukunyakaza kwezihlunu), ukufihla ukuhamba kwamanzi kunye nokuhamba kwegazi. I-ENS ilawula uxanduva oluninzi ngokwabo kangangokuba ngamanye amaxesha linikezwa igama elithi "ingqondo encinane." Ngenxa yale nkcazo, kulula ukubona ukuba ukuqonda indlela inkqubo ye-enteric esebenzayo kubalulekile ukuze kuqondwe oko kuhamba kakubi umzimba kunye ne-IBS.
I-Staitcase Down
Unxibelelwano lendlela yesibini xa ifika kwingqondo (inkqubo yesantya ephakathi) kunye nenkqubo yokutya (inkqubo ye-nervous system). Iindlela ezihambelanayo zidibanisa ingqondo kunye namathumbu ngolwazi olujikelezayo ngokuphindaphindiweyo. Olu xhumo olusondeleyo luyabonakala ngokucacileyo kwimpendulo yethu ekuxinekeni (esichengeni esichengeni), ebonisa ukuba olu nxu lumano olunxibelelwano lubaluleke kakhulu ekusindeni kwethu njengezilwanyana.
Abaphandi bafumana ubungqina bokuthi ukungasebenzi kakubi kule ndlela kunye neendlela eziphantsi kunokuba negalelo kwiintlungu zesisu , ukuzitywa kunye / okanye urhudo oluyimpawu ze-IBS. Amagulane emanzini abhekene nobutyebi obugqithiseleyo angabangela inguqu kwingqondo.
Iingcamango, iimvakalelo, kunye nokusebenza kweengxenye zengqondo ezijongene nokuxhalaba okanye ukuvuswa kungakhuthaza iimpendulo zesisu. Ukungasebenzi kakubi kufumaneka kwiindlela ezininzi ezahlukeneyo ezidibanisa ubuchopho kunye nesisu. Ngokomzekelo, kukho ubungqina bokusebenza ngokungavumelekanga kwimizila emibini eyahlukeneyo kwinkqubo ye-nervous autonomic ehambelana nesifo sohudo kunye nempawu yokuqhaqha. Ngokuqhelekileyo, kubonakala ukuba ukungasebenzi komzimba kwinkqubo yokunxibelelana kwamathambo kuphazamisa amandla omzimba wokugcina i-homeostasis, ilizwe apho zonke iinkqubo zisebenza kakuhle.
Indima yeSerotonin
I-biology eyongezelelweyo: Iindlela apho iselfowuni esisinye sisetyenziselwa ukulandelana kunye nangemichiza ebizwa ngokuthi i- neurotransmitters . I-neurotransmitter ebaluleke kakhulu ekusebenziseni ukugaya ukutya yi-serotonin (5-HT). Kulinganiselwa ukuba ukuya kuma-95 ekhulwini we-serotonin emzimbeni womntu kufumaneka kwindlela yokugaya. I-Serotonin ithathwa njengeyona nxalenye ebalulekileyo kwinkqubo yokunxibelelana phakathi kwengqondo kunye nesisu. I-Serotonin ibonakala idlala inxaxheba kwi- motility , uvakalelo , kunye nokukhutshwa kwamanzi. Ukuhamba, ubuhlungu bentlungu kunye nomlinganiselo wamanzi e-stool - uyabona ukuba kutheni i-serotonin ijolise kubaphandi be-IBS.
Ukungafani kuye kwafunyanwa kumanqanaba e-serotonin phakathi kwezigulane ezinobulwelwe nxamnye nalabo abanokuqhawulwa. Izigulane ezinehudo ziphezulu kunamazinga aqhelekileyo e-serotonin egazini lawo emva kokutya, ngelixa izigulane ezithinteka ekuzibambeni zinomgangatho ophantsi kunezinga eliqhelekileyo le-serotonin. Lo mahluko uchaza iinzame zokuphuhlisa amayeza anokunyusa okanye anciphisa amanqanaba e-serotonin ngokujolisa kwiindawo ezithile zokufumana i-receptor ( 5-HT3 kunye no-5-HT4) ukuphatha i-IBS. Kukho imithi emibili enjalo, kodwa zombini isithintelo esiqinileyo ekusebenziseni kwabo ukukhusela imiphumo emibi kakhulu:
- Lotronex : i-blocker ye-5-HT3 yokunyanga kwehudo
- I-Zelnorm: L i-5-HT4 evuselela unyango lokubanjwa
Ukhokelo olutsha olutsha lwe-IBS lujolise kwiklasi yeeprotheni ezibizwa ngokuba yi-serotonin reuptake transporters (SERTs). I-SERT ixanduva lokususa i-serotonin emva kokuba ikhishwe. Kukho isibonakaliso sokuba kukho ukungafani kumsebenzi we-SERT xa i-IBS okanye ukuvuvukala kubakho. Esinye isikolo sombono kukuba ukugqitha kwe-serotonin kukuphazamisa inkqubo ye-homeostasis, oko kukuthintela ukuba inkqubo yokugaya isebenze ngendlela eqhelekileyo.
Ulwazi nguMandla
Ungayiguqulela njani ulwazi olutsha ekuncedeni ukulawula kakuhle i-IBS yakho? Kucacile ukuba awunalo igunya lokuchaphazela ngqo amazinga akho ase-serotonin. Nangona kunjalo, kukho imimandla emibini apho izenzo zakho zineempembelelo ngqo kwiinkqubo zonxibelelwano phakathi kwengqondo kunye nesisu.
Ngokusebenzisa iindlela zokuphumula , unokusebenza ngokukhawuleza ukucima impendulo yokunyamezela, apho utshintsho olushushu luvela khona ekuphenduleni iingcamango neemvakalelo. Unokuqwalasela kwakhona i-reflex ye-gastrocolic apho iziphambano ze-colon zivuselelwa ngokutya ukutya okuninzi okanye ukutya okunamafutha xa ugqiba ukutya okutya. Ukuze uhudo, kungcono ukuba udle ukutya okuncinci, ngelixa ukutyunjwa, isidlo esikhulu siza kulungele ukunyakaza.
Ukuqonda ukuba iingxaki kwi-IBS zandiselela ngaphaya kokuba "nesisu esisisigxina" kunokukunceda ukuphuhlisa iindlela ezahlukeneyo zokujongana nalezi ngxaki.
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