Okukhethwa kwamachiza okugqitywa kwe-FDA olutsha olutsha olwenziwe ngokuthwala
I-neurology yintsimi eguqulayo ngokukhawuleza, kunye neentuthuko ezintsha ezenzeka ngexesha lonke. Kwintsimi yokuhluthwa, amayeza amancinci amancinci amancinci amahlanu avunywe yi-Food and Drug Administration (FDA) kwiminyaka emihlanu phakathi ko-2012 no-2017.
Ziyintoni na le Mithi
Uninzi lwala mayeza lugunyazisiwe ukuba luthathwe ngokukhawuleza, oko kukuthintela ukuqala kwindawo enye yengqondo kunokuba yonke into kanye.
Ukongezelela, ezinye zezilwanyana ezinokutsha zokuxhatshazwa zisetyenziselwa ukunyanga ukunyanga abantwana, njengeLennox-Gastaut syndrome.
Ezinye zala mayeza asetyenzisiwe ngaphandle kweleta, nto leyo ithetha ukuba oogqirha bawachazela izinto ngaphandle kokuba i-FDA ivumele ukuba inkampani ipapashe.
ITrokendi XR (Topiramate)
Nangona i-topamamate (Topamax) ivunyiwe yi-FDA ngo-1997 ukwenzela unyango lwangaphambili lokubanjelwa kwinqanaba, le nguqulo ekhutshwayo, eyayivunyiweyo yi-FDA ngo-2013. I-Trokendi XR ingasetyenziselwa yedwa kwizigulana ezi-10 okanye ngaphezulu ezithatha inxaxheba okanye i-tonic-clonic ekutshatyalaliswa kwaye njengonyango lwesibini kwizigulana ezineminyaka engama-6 okanye ngaphezulu ezithintelayo okanye i-tonic-clonic seizures okanye i-Lennox-Gastaut syndrome.
Imiphumo emibi ingabandakanya ukudideka, iingxaki zengqondo, ukungcola, ukukhathala, ukuguquka okanye ukuvutha kwintsholongwane, iingxaki zeememori, ubunzima bokugxilwa, ukukhulelwa, ukukhulelwa, ukunyuka kwegazi, ukulahlekelwa kwesisindo, ukulala, ukukhathazeka, iingxaki zokuqonda, kunye nokunciphisa iingcamango nokuhamba.
I-Trokendi XR i-capsule ithathwe kanye kanye ngosuku.
Umlambo (Brivaracetam)
Kuyavunyelwa ngo-2016, i-brivaracetam ijoliswe ngokukodwa njengonyango lwesibini ukunyanga ukuhlaselwa kweengxaki ezifumanekayo ekuthotheni kwizigulane ezingama-16 okanye ngaphezulu. Isebenza ngokuthinta iprotheyini ebizwa ngokuba yi-synaptic vesicle 2A, eyanceda ukuyeka ukuwa.
Imiphumo emibi ingabandakanywa isicupunu okanye ukuhlanza, ukukhathala, utywala kunye nokulala. Umlenze unokuphathwa njengepilisi, ijoyi, okanye isisombululo somlomo, zonke zifakwe kabini ngosuku.
I-Qudexy XR (i-Topiramate)
NjengoTrokendi XR, i-Qudexy XR yenye enye inguqu yokukhululwa kwe-topiramate eyavunywa ngo-2014. I-Qudexy XR ikwajoliswe ku-monotherapy kwizigulana ezi-10 okanye ngaphezulu ezithatha inxalenye okanye i-tonic-clonic. kwizigulana ezi-2 ubudala nangaphezulu ezithatha inxalenye okanye i-tonic-clonic seizures okanye i-Lennox-Gastaut syndrome. I-Trokendi XR igqithiselwe kwizigulana ezi-6 ubudala nangaphezulu.
Imiphumo emibi ye-Qudexy XR inokuquka ukudideka, umkhuhlane, utywala, ukulala, iingxaki zememori, ukukhathazeka kanzima, i-anorexia, ukusuleleka, iingxaki zemizwelo, ukukhathazeka, ukulahlekelwa kwesisindo, imiba engqondweni, ukutshisa okanye ukutshitshiswa kwesikhumba, kunye nokunciphisa iingcamango nokuhamba . Kuthathwa njenge-capsule kanye ngosuku.
I-Aptiom (i-Eslicarbazepine Acetate)
I-Aptiom, evunyiweyo ngo-2013, i-blocker-gated channel blocker esetyenzisiweyo njengonyango lwesibini kwizigulane ezinokuthi ziqalwe ngokukhawuleza. Indlela esebenza ngayo ayibonakali kwaye ayisaziwa ukuba ikhuselekile ukuyisebenzisa kubantwana abangaphantsi kweminyaka engama-4.
Imiphumo emibi ingabandakanya intloko, isicathulo, ubuthongo, ukukhathala, i-vertigo, ukuthuthumela, umbono ogqabileyo, isisulu, ukuhlanza, umbono ombini, ukuzondla, kunye nokuhamba okungahambelaniyo. I-Aptiom yi-tablet eyenziwa kanye ngosuku.
Fycompa (i-Perampanel)
Njengezinye ezichasene ne-epileptics phambi kwayo, i-perampanel inendlela entsha yokusebenza, ijolise kwi-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) ionotropic receptor i-receptor. I-Perampanel inokusebenzisana nezidakamizwa ezifana ne-carbamazepine, i-oxcarbazepine, okanye i-phenytoin kwaye isetyenziselwa ukuphatha abantu abadala kunye nabantwana abaneminyaka eli-12 ubudala okanye ngaphezulu kunomdla wokunciphisa, okwesibini ukuxhatshazwa, okanye ukuthatha i- tonic-clonic .
Imiphumo emibi ingabandakanya ukungcola, ukufumana ubunzima, ukukhathala, ukucaphuka, ukuwa, iingxaki zokulinganisela, ukulala, ukunyakaza okungabonakaliyo, kunye neentlanzi. I-Fycompa i-tablet eyenziwa kanye ngosuku.
Amachiza amatsha afana neNew Hope
Okwangoku, malunga nesithathu kwezigulane ezinokuhluthwa ziye zithintekayo ezingenakulawulwa kakuhle ngamachiza kuphela. Ngokuqulunqa amayeza amasha ngeendlela ezintsha, ithemba lethu ngelinye ilanga libe nehlabathi elithatha inkululeko.
> Imithombo:
> Franco V, i-French JA, i-Perucca E. Imingeni kwiCandelo loPhuhliso lweeNtsholongwane zeAn Antipilepile. Uphando lwezeMpilo . NgoJanuwari 2016; 103: 95-104.
> I-Watch Watch. I-FDA evunyelwe izidakamizwa ze-Neurology. 2017.