Ubudala bakho ngexesha lokukhulelwa kokuqala kunokunciphisa ingozi yomhlaza wesisu. Mhlawumbi uvile le statistical, kodwa yintoni esiyithetha ngayo iminyaka, kwaye kutheni le nto ingaba yinyaniso?
Ininzi yeenzuzo zokuba nomntwana angabonakaliyo, ingqondo, kunye nentlalo. Kodwa nangobu bunye ubungqina bokuthi ukukhulelwa kukunika isipho sempilo-umgca wokulwa nokuvelisa umdlavuza webele.
Ukukhulelwa kunye nokuxiliswa kwe-Breastfeeding Lower Estrogen Exposure
Ukukhulelwa ngaphambi kweminyaka engama-30 kunye nokuncelisa kuncitshisa inani elipheleleyo lexesha lokuphila kwimihla yokuphila, okucingelwa ukuba iyona sizathu sokuba bancede banciphise umngcipheko. Ihommone i-estrogen enefuthe i-80% yazo zonke iintsholongwane zomhlaza. Ekubeni ukukhulelwa kunye nokuhlambalaza kunciphisa amanqanaba akho e-estrogen, umngcipheko wakho uyancipha rhoqo xa ukhulelwe kwaye xa unonyamekela umntwana wakho, ubuncinane ukuya kwinqanaba.
Ngaba Ubudala Kwixesha Lokukhulelwa?
Ngokutsho kweNational Cancer Institute, ukukhulelwa kwexesha elipheleleyo okanye ngaphambi kokudala iminyaka engama-20 kunika ukhuselo oluphezulu ekukhuseleni umdlavuza webele. Oku kunokunciphisa ingozi yomhlaza wesifuba kwisiqingatha malunga nabasetyhini abanomntwana oneminyaka engama-35 okanye ngaphezulu okanye abanakho abantwana. Ukuncelisa isisu kugcina amanqanaba akho e-estrogen aphantsi, ngoko unganayo imithwalo yokukhulelwa ngaphambi kokukhulelwa kwe-estrogen de lwakho usana lukhulile.
Ukukhulelwa kwakho kokuqala kwiminyaka engama-30 okanye ngaphezulu kunika ukhuselo oluncinci kumdlavuza webele.
I-Alpha-fetoprotein, iprotheni eyenziwa ngumntwana ngexesha lokukhulelwa, inceda ukulawula ukukhula komntwana. Inokukunceda ukunqanda iiseli zomhlaza zesisu. Ngaphezulu kweminyaka engama-30, i-alpha-fetoprotein isebenza ngokungafaniyo, kwaye inokunceda ngokwenene iphromotha kunokunqanda ukuphucula umdlavuza webele.
Indlela Ukukhulelwa Kukuthintela Ukuthintela Ngomhlaza Webele
Amabele aphuhliswa ngexesha lokukhulelwa, xa amazinga e-hormone ashintsha ngokukhawuleza kunye nokukhula komzimba.
Iiseli zesisu zomzimba zifikelela ekuvuthweni okupheleleyo emva kokukhulelwa kwexesha elipheleleyo. Amabele akho aphethwe ngumjikelezo wokuqala wokuya esikhathini ukuya ekukhulelweni kwakho kokuqala. Umcwaningi u-Irma Russo, i-MD ye-Fox Chase Cancer Centre eFiladelphia ikholelwa ukuba ukunciphisa ixesha apho iiseli zesifuba zincinci zibonelela ngokukhuselekileyo ekukhuselweni komhlaza. Ihomoni eveliswa ngexesha lokukhulelwa, i-chorionic gonadotropin (hCG) yabantu, ibangela ukuba iiseli zesifuba zikhule kwaye zikhusele ekuphuculweni komhlaza. I-hormone yokukhulelwa iHCG iyabangela utshintsho olusisigxina kwimfuyo yakho, kwaye ezi tshintsho zemizimba zingakwazi ukunqanda umdlavuza webele.
Ngexesha lokukhulelwa, iiseli ze-fetal ziveliswa, kwaye ezo iiseli zihlala kwindawo yakho yokujikeleza kwexesha elide emva kokukhulelwa kwakho. Ubuchule beetyeli eziqhubekayo ezijikelezayo malunga negazi lakho libizwa i-microchimerism ye-fetal (FMc). Uphando olwenziwe nguDkt. Vijayakrishna K. IGadi le-Fred Hutchinson iZiko loPhando lweCans e Seattle libonisa ukuba ezi seli seli-fetal zingakunciphisa umngcipheko wesifo somhlaza webele. I-fetal microchimerism inokubangela ukukhusela ngokukhusela isistim somzimba wakho sokuzivikela ukuba uqaphele iiseli ezinobungozi (umdlavuza) ukutshabalalisa.
"Siyazi ixesha elithile ukuba ukukhulelwa kunokukhusela umdlavuza webele," kusho uGadi, "kodwa iziphumo zethu zinceda ukujongana nesigqibo sokuba kutheni bonke abafazi bekhuselekile." Kodwa abaphandi banethemba lokwenza isicelo esizayo malunga neziphumo zabo. "Ngezinye iinjongo," wongezelela uGadi, "sinokukwazi ukuphuhlisa iiseli ze-fetal njengendlela yokonyango kwebele okanye ezinye iindidi zeekhensi."
Ukukhulelwa akusisigunyaziso soKhuseleko
Ukukhulelwa, akunjalo, kodwa kunika ukhuselo olupheleleyo kumdlavuza webele. Kunokwenzeka ukuba ufumane umhlaza wesisu ngexesha lokukhulelwa kwaye uphathwe nge-chemotherapy.
Ukuxilongwa komhlaza wesisu ngexesha lokukhulelwa kuyinto engavumelekanga: enye kuphela kwi-3,000 (0.03%) ukuya kwi-10 000 (0.01%) abafazi abakhulelweyo bafumana ukuba banomdlavuza wesibele. Kukho ukwanda okwenziwe ngokubonakalayo kwimihlaza yebele yobumbele kunyaka wokuqala emva kokukhulelwa, emva koko emva kokuhla kwexabiso elingaphantsi kwexabiso labo bangakhange bakhulelwe baze bangazalanga.
Ukukhulelwa nokukhulelwa emva kweCarcer Breast
Ukuba ufumene ukuba unomdlavuza webele, i-chemotherapy kunye neyeza zokulandela ezifana ne-estrogen suppressors kunye ne-aromatase inhibitors kunokubangela ukuba ama-ovari akho ayeke ukusebenza ixesha elithile. Ngeli xesha, unokuba usisithuba esingasemva kwexesha, kodwa ukuba awukakho okwexeshana emva kokonyango, ukuzala kwakho kungabuya emva kweenyanga ezili-6 ukuya kwe-12 emva kokuba i-chemotherapy iphelile. Unakho ukhetho lokuqanda amaqanda okanye ama-embroyi phambi kokuba uqale unyango, kubalulekile ukuba akukho mqinisekiso malunga nokuzala kwangomso. I-website ye-American Cancer Society ithi, "Nangona ukukhathazeka ukuba ukukhulelwa kungabangela ukuba umhlaza uphinde ubuyeke, uphando oluya kumhla aluzange lubonise ukuba lunyani nawuphi na uhlobo lomhlaza." Uninzi lwababeleki besisu abanomdla abanqwenela ukuba nabantwana emva kokuba unyango luxhala malunga neenguqu zokukhulelwa kwe-hormonal ekwenzeni ukuphindaphinda, kodwa izifundo azibonisanga umahluko ngokuphindaphindiweyo kunye okanye ngaphandle kokukhulelwa kwezonyango.
Imithombo:
Baron, M., Santucci-Pereira, J., noJusso. Izindlela ze-molecular ezibandakanyeka ekukhuseleni-ukukhusela ukukhusela umdlavuza webele. Imida kwi-Endocrinology . 2014. 5: 213.
Gadi, V., noJ. Nelson. I-fetal microchimerism kubasetyhini abanomdlavuza wesibele. Uphando lweCancer . 2007. 67 (19): 9035-8.
Gadi, V. I-Fetal microchimerism ebelekweni kwabasetyhini kunye nangengomdlavuza webele. Uphando lwe-Cancer noPhando lwe-Cancer 2010. 121 (1): 241-4.
National Cancer Institute. I-Prevention Cancer Prevention (PDQ). Ukuhlaziywa 10/22/15.
Russo, I. I-Fox Chase Cancer Centre. Ingxelo yoLungiso. Utshintsho lwe-Genetic kwiisifuba zesifuba ezibangelwa ukukhulelwa kwe-hormone kunceda ukunqanda umdlavuza webele. Ishicilelwe: 04 / 20/2005.