I-Carcinoma Kwimeko Yesiko, Ukubonakala Kwemicroscopic, kunye Nekhono Lokusasazeka
Ngobuchule bokuqala bokufumanisa, ngoku sele sifumana amaninzi emdlavuza kwinqanaba lokuba bathathwa njenge-carcinoma in situ (CIN). Ngethuba langoku asikho indlela yokuqinisekisa ukuba i-CIN iya kutshintsha kumdlavuza, kodwa inkoliso yexesha i-CIN ithathwa njengengozini yokuba ngumhlaza ongenawo umonakalo. Yintoni ekuthethwa ngayo ngekota CIN, yintoni i-cancers inokuba ne-carcinoma esecaleni, kwaye ihluke njani kumhlaza ongenawo?
Inkcazo: I-Carcinoma In Situ (CIN)
I-carcinoma in situ ligama elisetyenziselwa ukuchaza umhlaza okhoyo kuphela kwiiseli apho uqalise kwaye awusasazekanga nakweyiphi iishukela eziseduze. I-carcinoma in situ iyona nqanaba lokuqala lomhlaza, kwaye kuthi, ngeli nqanaba, libheke "elingenasiphelo." Ngokubhekiselele kwisigxina, i-carcinoma in situ ithathwa njengesigaba somhlaza wesi-0. Isigaba soku-1 ukuya kwisigaba se-4 sonke sithathwa njenge-"invasive" kansa.
Ukubonakala kweMicroscopic
Ukuxilongwa kwe-carcinoma in situ kufuneka kwenziwe phantsi kwe-microscope, apho ichazwa ngokuba khona kwamaseli omhlaza. Iiseli ze-Cancer zihluke kwiiseli eziqhelekileyo ngeendlela ezininzi , kungekhona nje ukukwazi ukusasaza.
I-Carcinoma In Situ vs Visive Carcinoma
Ngokuchasene ne-carcinoma, okanye umdlavuza ongenayo, i-carcinoma in situ ayizange ifakwe kwisalathisi sangaphantsi, kwaye akukho nto ihlasela ngayo. Ngaphandle kwalokhu-into yokuba iiseli azikaphulwanga kwisakhiwo esixhasayo apho ziqala khona-iiseli zibonakala zifana neeseli zesifo somhlaza zingabonakala phantsi kwe-microscope.
I-Carcinoma In Situation
Ngeendlela ezininzi, igama elithi "carcinoma" lilingana nomhlaza. Phantse ama-85 ekhulwini lamanomdla angama-carcinomas. I-carcinomas zakhiwe ngamaseli e-epithelial; uhlobo lweeseli ezidibanisa isikhumba, amathunga emfuyo kunye nezinye izakhiwo zamalungu omzimba.
Amagqabha e-carcinomas afaka i-adenocarcinoma, i-squamous cell carcinoma, i-transitional cell carcinoma (kwi-bladder okanye izinso), kunye ne-basal cell carcinoma.
I-carcinoma in situ inokuchazwa ngakumbi ngoluhlobo lwesisu apho umdlavuza uqala khona. Ngokomzekelo, i-squamous cell carcinoma in situ yomlomo wesibeleko yayiza kumelana nomhlaza owaye waqala kwiiseli ezinqamlezayo ezenza umgca we-cervix kwaye ungakabikho.
Izidumbu ezifana ne-sarcomas zivela kwizicubu ezingenayo i-membrane engaphantsi komhlaba ukwenzela ukuba ezi ntlobo zomhlaza azikho isigaba se-carcinoma. Ngamanye amagama, isifo esinomdlavuza we-bone (i-osteosarcoma) asinaso isigaba sokuqala (asikho isigaba seCIN) kwaye iiseli ziyakucingwa ukuba ziqhelekileyo okanye umhlaza. Ngeengqungquthela ezingenayo i-CIN yesigaba, iimvavanyo zokuhlola (ezifana nePap smear) azisebenzi kakuhle ekutholeni kwangaphambili.
Iintsholongwane ezinokuthi zifumaneke njengeCIN
Ngokwemfundiso, nayiphi na umdlavuza oqala kwiiseli ze-epithelial uya kuba neCIN. Eyona nto iqhelekileyo uya kuyiva malunga noko, nangona kunjalo, ziquka i-CIN yebele (zombini i- ductal carcinoma in situ (DCIS) kunye ne- lobular carcinoma in situ (LCIS) , i-bladder, imiphunga ( isifo somhlaza wemiphunga 0 ), isibeletho ( inzala ye-intraepithelial neoplasia ) kunye nesikhumba ( squamous cell carcinoma in situ ).
I-Carcinoma In Situ (CIN) vs Cancer
Umbuzo wezigidigidi zedola ngokutsha, ngokukodwa ngokuphikisana nokunyanga kwe-carticoma ye-ductal in situ okanye kwi-situ yesifo somhlaza, nokuba ingaba i-carcinoma in situ ingumdlavuza ngokwenene.
Impendulo kukuba kuxhomekeke ekubeni ngubani othetha naye. Abanye oogqirha bahlela i-carcinoma in situ njengomdlavuza ongeyomonakalo kwaye abanye banokukhetha ukuyibiza ngokuba ngumhlaza ngaphambi komhlaza. Ukwahlukana kwakuya kulwa ukuba uyazi ukuba i-CIN ingaqhubela phambili kumdlavuza ongenawo umonakalo, kwaye ukuba, ngencazelo, ayiyazi. Kananjalo asikwazi ukufumana iimpendulo kungekudala, njengoko kungayi kuba nemilinganiselo yokujonga kuphela inani elikhulu le-carcinoma e-situ ukuze libone ukuba ngaba ngumhlaza osasazekayo kwaye usasazeka.
ICarcinoma In Situ vs Precancerous Cells vs Dysplasia
Amanqaku amaninzi achaza uluhlu lweeseli eziqhelekileyo kunye namaseli esifo somhlaza. Enye yale dysplasia.
I-Dysplasia iyakwazi ukuqhuba i-dysplasia epholileyo apho iiseli zingabonakali ngokungaqhelekanga kwi-carcinoma in situ, abathi ezinye i-pathologists zichaza njenge-dysplasia enamandla ebandakanya ubuninzi be-epithelium. Ixesha eliqhelekileyo lingasetyenziselwa ukuchaza iiseli eziqhubekayo phakathi kweeseli eziqhelekileyo kunye nomhlaza.
Isigaba seCanscer, iCarcinoma In Situ, kunye neMigangatho eyongezelelweyo
Umbuzo oqhelekileyo uthi, "Nguwuphi umlinganiselo womhlaza we-carcinoma in situ?" I-carcinoma in situ ibhekiselwa kumhlaza wesi-0. Kule nqanaba, umdlavuza uthathwa njengengenayo. Amanqanaba omhlaza we-Stage 1 nangaphaya ayaqwalaselwa njengongenayo. Amanye amagama angasetyenziselwa ukuchaza into efanayo ne-carcinoma in situ okanye isigaba somhlaza wesi-0 zibandakanya ukungena-ukungena ngaphakathi, ukungena-invasive kunye ne-intra-epithelial.
Unyango
I-carcinoma in situ isuswe ngokugqithisa, nangona uhlobo lotyando luya kuxhomekeka kwindawo leyo, kwaye nakwiindawo ezithile kukho ukungqubuzana okukhulu. Ezi zigqibo zenziwe ngokusekelwe kwimeko ethile yokungaqhelekanga, izinto ezinobungozi ezibonisa ukuba i-CIN inokuthi ibe ngumhlaza ongenawo umonakalo, ubudala bomntu kunye nokunye okuninzi. Abanye abantu baziva bekhululekile bebona ukungaqhelekanga kanti abanye banqwenela ukuba nayiphi na into enokuba ngumhlaza isuswe.
Kwaziwa ngokuba: Umhlaza wesi-0
> Imithombo:
> Merrill, A., Esserman, L., noMn. Morrow. I-Caructoma ye-Ductal In Situ. I-New England Journal of Medicine . 2016. 374: 390-392.
> INational Cancer Institute. Iimodyuli zokuqeqesha. In Situ (Isigaba = 0).